Detailed view for EgrG_000599900

Basic information

TDR Targets ID: 592152
Echinococcus granulosus, NADPH:adrenodoxin oxidoreductase
Source Database / ID:  GeneDB

pI: 8.082 | Length (AA): 529 | MW (Da): 58287 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF07992   Pyridine nucleotide-disulphide oxidoreductase

Gene Ontology

Mouse over links to read term descriptions.
GO:0016491   oxidoreductase activity  
GO:0055114   oxidation reduction  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 3 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
19 518 1lqt (A) 2 456 36.00 0 1 1.26538 -0.15
21 57 3c4a (A) 1 37 27.00 0 0.17 0.313143 0.24
23 515 1cjc (A) 9 457 50.00 0 1 1.47575 -0.6

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_128406)

Species Accession Gene Product
Arabidopsis thaliana AT4G32360   pyridine nucleotide-disulfide oxidoreductase family protein
Babesia bovis BBOV_I000680   conserved hypothetical protein
Brugia malayi Bm1_54850   NADPH:adrenodoxin oxidoreductase, mitochondrial precursor
Candida albicans CaO19.3521   highly similar to N terminus of S. cerevisiae ARH1 (YDR376W) mitochondrial adrenodoxin-like oxidoreductase
Candida albicans CaO19.8040   similar to adrenodoxin oxidoreductase, ferredoxin-NADP+ reductase, EC 1.18.1.2, mitochondrial in S. cerevisiae
Candida albicans CaO19.11004   highly similar to N terminus of S. cerevisiae ARH1 (YDR376W) mitochondrial adrenodoxin-like oxidoreductase
Candida albicans CaO19.410   similar to adrenodoxin oxidoreductase, ferredoxin-NADP+ reductase, EC 1.18.1.2, mitochondrial in S. cerevisiae
Caenorhabditis elegans CELE_Y62E10A.6   Protein Y62E10A.6
Cryptosporidium hominis Chro.80316   NADPH:ferredoxin oxidoreductase
Cryptosporidium parvum cgd8_2710   NADPH:ferredoxin--NADP+ reductase with a rossman fold nucleotide binding domain and a 2Fe-2S ferredoxin domain
Dictyostelium discoideum DDB_G0287353   NADPH:ferredoxin oxidoreductase
Drosophila melanogaster Dmel_CG12390   defective in the avoidance of repellents
Echinococcus granulosus EgrG_000599900   NADPH:adrenodoxin oxidoreductase
Echinococcus multilocularis EmuJ_000599900   NADPH:adrenodoxin oxidoreductase
Homo sapiens ENSG00000161513   ferredoxin reductase
Leishmania braziliensis LbrM.21.0480   ferredoxin NADP reductase-like protein
Leishmania donovani LdBPK_210480.1   NADPH:adrenodoxin oxidoreductase, mitochondrial, putative
Leishmania infantum LinJ.21.0480   ferredoxin NADP reductase-like protein
Leishmania major LmjF.21.0420   ferredoxin NADP reductase-like protein
Leishmania mexicana LmxM.21.0420   ferredoxin NADP reductase-like protein
Loa Loa (eye worm) LOAG_13401   hypothetical protein
Loa Loa (eye worm) LOAG_04928   hypothetical protein
Mycobacterium leprae ML0666c   Probable NADPH:adrenodoxin oxidoreductase FprA (NADPH-FERREDOXIN REDUCTASE)
Mus musculus ENSMUSG00000018861   ferredoxin reductase
Mycobacterium tuberculosis Rv3106   NADPH:adrenodoxin oxidoreductase FprA (NADPH-ferredoxin reductase)
Mycobacterium ulcerans MUL_2413   NADPH:adrenodoxin oxidoreductase FprA
Mycobacterium ulcerans MUL_2699   NADPH:adrenodoxin oxidoreductase FprA
Neospora caninum NCLIV_026250   NADPH:adrenodoxin oxidoreductase FprB, related
Oryza sativa 4329009   Os02g0277600
Onchocerca volvulus OVOC207   NADPH:adrenodoxin oxidoreductase, mitochondrial homolog
Plasmodium berghei PBANKA_0909300   adrenodoxin reductase, putative
Plasmodium falciparum PF3D7_1139700   adrenodoxin reductase, putative
Plasmodium knowlesi PKNH_0937600   adrenodoxin reductase, putative
Plasmodium vivax PVX_192290   unspecified product
Plasmodium vivax PVX_202290   unspecified product
Plasmodium vivax PVX_092585   adrenodoxin reductase, putative
Plasmodium vivax PVX_191290   unspecified product
Plasmodium yoelii PY02070   MFDR, putative
Saccharomyces cerevisiae YDR376W   Arh1p
Schistosoma japonicum Sjp_0217420   ko:K00528 ferredoxin--NADP+ reductase [EC1.18.1.2], putative
Schistosoma mansoni Smp_166580   ferredoxin/ferredoxin--NADP reductase-related
Schmidtea mediterranea mk4.001786.00   NADPH:adrenodoxin oxidoreductase, mitochondrial
Trypanosoma brucei gambiense Tbg972.10.2700   adrenodoxin reductase, putative,ferredoxin NADP reductase-like protein
Trypanosoma brucei Tb927.10.2230   NADPH:adrenodoxin oxidoreductase, mitochondrial, putative
Trypanosoma congolense TcIL3000_10_1840   NADPH:adrenodoxin oxidoreductase, mitochondrial, putative
Trypanosoma cruzi TcCLB.511367.230   NADPH:adrenodoxin oxidoreductase, mitochondrial, putative
Toxoplasma gondii TGME49_261030   pyridine nucleotide-disulfide oxidoreductase domain-containing protein

Essentiality

EgrG_000599900 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
mtu3159 Mycobacterium tuberculosis non-essential nmpdr
Tb927.10.2230 Trypanosoma brucei significant gain of fitness in bloodstream forms (3 days) alsford
Tb927.10.2230 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (6 days) alsford
Tb927.10.2230 Trypanosoma brucei significant gain of fitness in procyclic forms alsford
Tb927.10.2230 Trypanosoma brucei significant gain of fitness in differentiation of procyclic to bloodstream forms alsford
CELE_Y62E10A.6 Caenorhabditis elegans embryonic arrest wormbase
YDR376W Saccharomyces cerevisiae inviable yeastgenome
PBANKA_0909300 Plasmodium berghei Essential plasmo
TGME49_261030 Toxoplasma gondii Probably essential sidik
Show/Hide essentiality data references
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

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User comments

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Gene identifier EgrG_000599900 (Echinococcus granulosus), NADPH:adrenodoxin oxidoreductase
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