Detailed view for EgrG_000262100

Basic information

TDR Targets ID: 592403
Echinococcus granulosus, ras GTP exchange factor
Source Database / ID:  GeneDB

pI: 8.5711 | Length (AA): 1071 | MW (Da): 120174 | Paralog Number: 1

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00617   RasGEF domain
PF00618   RasGEF N-terminal motif
PF00621   RhoGEF domain

Gene Ontology

Mouse over links to read term descriptions.
GO:0046578   regulation of Ras protein signal transduction  
GO:0005089   Rho guanyl-nucleotide exchange factor activity  
GO:0005085   guanyl-nucleotide exchange factor activity  
GO:0035023   regulation of Rho protein signal transduction  
GO:0007264   small GTPase mediated signal transduction  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 8 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
1 101 3gf9 (A) 1262 1366 32.00 0.0000053 0.72 0.494204 -0.45
2 90 5n7e (B) 584 679 34.00 0.0015 0.12 0.338 0.1
3 101 3gf9 (A) 1267 1366 26.00 0 0.87 0.493737 -0.9
4 218 2pz1 (A) 370 568 26.00 0 0.97 0.392047 0.4
574 1040 1xdv (A) 381 926 18.00 0 1 0.567341 0.79
753 1063 6axf (A) 23 320 23.00 0.00000000076 1 0.527583 0.12
888 1035 3qxl (A) 44 193 32.00 0 1 0.593489 -0.75
895 1065 2ije (S) 1030 1212 44.00 0.000000042 1 0.656864 -0.68

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_130783)

Species Accession Gene Product
Dictyostelium discoideum DDB_G0269252   Ras guanine nucleotide exchange factor
Dictyostelium discoideum DDB_G0276019   RasGEF domain-containing protein
Echinococcus granulosus EgrG_000262100   ras GTP exchange factor
Echinococcus granulosus EgrG_000262200   ras specific guanine nucleotide releasing factor
Echinococcus multilocularis EmuJ_000262100   ras GTP exchange factor
Echinococcus multilocularis EmuJ_000262200   ras specific guanine nucleotide releasing factor
Homo sapiens ENSG00000058335   Ras protein-specific guanine nucleotide-releasing factor 1
Homo sapiens ENSG00000113319   Ras protein-specific guanine nucleotide-releasing factor 2
Mus musculus ENSMUSG00000032356   RAS protein-specific guanine nucleotide-releasing factor 1
Mus musculus 19418   RAS protein-specific guanine nucleotide-releasing factor 2
Schistosoma japonicum Sjp_0014260   Ras-specific guanine nucleotide-releasing factor 1, putative
Schistosoma japonicum Sjp_0100740   ko:K04349 Ras guanine nucleotide-releasing factor, putative
Schistosoma japonicum Sjp_0014250   IPR008937,Ras guanine nucleotide exchange factor,domain-containing
Schistosoma mansoni Smp_127770   ras GTP exchange factor
Schmidtea mediterranea mk4.009161.00  
Schmidtea mediterranea mk4.005291.00  
Schmidtea mediterranea mk4.021139.00   Putative ras GTP exchange factor

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier EgrG_000262100 (Echinococcus granulosus), ras GTP exchange factor
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