Detailed view for EgrG_000452000

Basic information

TDR Targets ID: 592645
Echinococcus granulosus, endonuclease exonuclease phosphatase

Source Database / ID:  GeneDB

pI: 7.0637 | Length (AA): 656 | MW (Da): 73241 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF03372   Endonuclease/Exonuclease/phosphatase family

Gene Ontology

Mouse over links to read term descriptions.
No GO information for this protein.

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 3 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
152 656 4zkf (A) 155 609 25.00 0 1 0.810217 0.42
152 652 4zkf (A) 155 605 30.00 0 1 0.785619 0.61
302 655 5dv4 (A) 186 538 24.00 0 1 0.714034 0.18

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_130415)

Species Accession Gene Product
Drosophila melanogaster Dmel_CG5954   lethal (3) malignant brain tumor
Echinococcus granulosus EgrG_000452000   endonuclease exonuclease phosphatase
Echinococcus multilocularis EmuJ_000452000   endonuclease exonuclease phosphatase
Homo sapiens ENSG00000154655   l(3)mbt-like 4 (Drosophila)
Homo sapiens ENSG00000185513   l(3)mbt-like 1 (Drosophila)
Homo sapiens ENSG00000198945   l(3)mbt-like 3 (Drosophila)
Mus musculus 320858   l(3)mbt-like 4 (Drosophila)
Mus musculus ENSMUSG00000039089   l(3)mbt-like 3 (Drosophila)
Mus musculus ENSMUSG00000035576   l(3)mbt-like (Drosophila)
Schistosoma japonicum Sjp_0110750   Lethal(3)malignant brain tumor-like 3 protein, putative
Schistosoma japonicum Sjp_0129040   Lethal(3)malignant brain tumor-like 4 protein, putative
Schistosoma mansoni Smp_159100   hypothetical protein
Schmidtea mediterranea mk4.023598.00  
Schmidtea mediterranea mk4.023947.00   LD05287p

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.


Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Homo sapiens l(3)mbt-like 3 (Drosophila) Compounds References
Homo sapiens l(3)mbt-like 1 (Drosophila) Compounds References
Homo sapiens l(3)mbt-like 4 (Drosophila) Compounds References
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets

Obtained from network model

Ranking Plot


Putative Drugs List


Compound Raw Global Species
0.0568 0.4626 0.5809
0.0227 0.7646 1
0.0207 0.2859 1
0.0205 0.3893 0.3893
0.0187 0.402 1
0.0227 0.5818 0.5818
0.0227 0.6273 1
0.0368 0.4743 0.4743
0.0157 0.2629 0.2606
0.04 0.5424 0.7009
0.0193 0.3221 0.3221
0.0393 0.287 0.287
0.0407 0.6415 0.9564
0.0339 0.2918 0.2918
0.0196 0.6205 0.6205
0.0222 0.6307 1
0.0191 0.2603 0.2603
0.0206 0.2588 0.2588
0.0227 0.6355 0.7857
0.0187 0.6067 1
0.0599 0.3428 0.5823
0.0209 0.6453 1
0.0173 0.2618 0.2618
0.0227 0.6375 1
0.0225 0.3174 0.3152
0.0187 0.3625 1
0.0227 0.2648 0.2648
0.0224 0.2991 0.2991
0.0218 0.4105 0.633
0.0196 0.6228 1
0.0227 0.5672 1
0.0227 0.4387 0.5582
0.0206 0.579 1
0.0227 0.3932 0.3932
0.0191 0.3717 0.457
0.06 0.3516 0.4628
0.0404 0.3815 1
0.0195 0.4977 0.4977
0.0197 0.2729 0.2729
0.0601 0.3267 0.3267
0.0189 0.4015 0.4013
0.0186 0.3172 0.5638
0.0193 0.3851 0.3848
0.0188 0.3433 0.3382
0.0182 0.5672 1
0.0203 0.5786 0.5712
0.0186 0.579 1
0.0515 0.2925 0.4384
0.0197 0.5396 1
0.0232 0.629 1
0.0227 0.628 1
0.0227 0.6286 1
0.0389 0.4362 0.517
0.02 0.6204 0.6204
0.0185 0.4017 0.4017
0.0189 0.633 1
0.0206 0.276 0.3005
0.0373 0.5536 0.5536
0.0624 0.4358 0.4358
0.1206 0.6187 1
0.0202 0.4607 0.4607
0.0191 0.6186 1
0.0215 0.5797 1
0.0187 0.6345 1
0.143 0.3429 0.3429
0.0375 0.4576 0.4833
0.0973 0.2612 0.4591
1.4813 0.6077 1
0.0182 0.6426 1
0.0192 0.6301 1
0.0227 0.579 1
0.0587 0.3558 0.3889
0.0818 0.4825 0.7853
0.0419 0.4514 0.4502
0.0184 0.4546 0.4546
0.0202 0.3251 0.9737
0.021 0.6341 0.6524
0.0198 0.5966 0.7624
0.804 0.6081 1
0.0187 0.5984 0.9566
0.0388 0.4049 0.4685
0.0206 0.2678 1
0.0182 0.2584 0.2584
0.0405 0.3138 0.3388
0.0194 0.2699 0.2698
0.0227 0.626 1
0.0187 0.3676 0.3676
0.0227 0.2706 1
0.0198 0.2505 0.2505
0.019 0.6278 1
0.0198 0.2701 0.2701
0.0186 0.3518 0.3518
0.0382 0.6416 0.6755
0.0187 0.6414 1
0.0393 0.643 1
0.0558 0.6045 0.8324
0.0203 0.2652 0.2652
0.0197 0.2505 0.2456
0.3951 0.6165 1
0.0188 0.4857 0.4857
0.0231 0.5868 0.5868
0.0226 0.5833 0.5589
0.0227 0.4541 0.4532
0.0205 0.2646 0.2646
0.0297 0.3612 0.5789
0.0394 0.6399 0.709
0.0216 0.4397 1
0.1177 0.3053 0.4038
0.0232 0.271 0.2702
0.039 0.634 1
0.0409 0.2699 0.2699
0.0438 0.4797 0.5824
0.0821 0.3385 0.6647
0.0563 0.4038 0.4038
0.0227 0.265 0.265
0.0223 0.4823 0.4823
0.0227 0.2655 0.5
0.0411 0.2705 0.2704
0.0418 0.5232 0.6182
0.0213 0.2589 0.5195
0.0201 0.5419 0.5412
0.019 0.3549 1
0.0211 0.579 1
0.0225 0.3729 0.6302
0.0647 0.3652 0.3684
0.7234 0.6122 0.6222
0.0227 0.6232 1
0.0185 0.5752 1
0.0215 0.264 1
0.0374 0.6376 1
0.0227 0.3037 0.3037
0.0201 0.2511 0.2492
0.0233 0.2695 0.7273
0.0164 0.3173 0.3159
0.0219 0.3864 1
0.04 0.2805 0.4784
0.914 0.6117 1
0.0201 0.6328 0.636
0.0191 0.6036 0.6036
0.0215 0.2707 0.2658
0.02 0.3791 0.5026
0.0423 0.481 0.481
0.0191 0.269 0.2627
0.0182 0.3082 1
0.0184 0.6363 1
0.1005 0.5924 1
0.0186 0.5704 0.5704
0.0618 0.5565 0.5565
0.0227 0.5752 1
0.0767 0.5959 1
0.0185 0.3949 0.4476
0.0186 0.6107 1
0.0209 0.3461 0.4695
0.0227 0.5498 1
0.0215 0.2568 0.4437
0.0209 0.6061 0.6042
0.0207 0.2623 0.513
0.0224 0.2757 0.3246
0.0202 0.619 1
0.0191 0.5987 1
0.0217 0.4451 0.4378
0.0228 0.312 0.312
0.0206 0.461 0.461
0.0609 0.6463 0.8944
0.0214 0.6325 0.7947
0.0209 0.2572 0.2362
0.0193 0.579 0.9545
0.0396 0.2662 0.2662
0.0235 0.3633 0.3633
0.0388 0.467 0.467
0.0203 0.352 0.3512
0.0573 0.639 0.639
0.0186 0.2672 0.2672
0.0203 0.3313 0.3915
0.021 0.567 0.567
0.0186 0.4993 0.8927
0.0227 0.2617 0.2617
0.0187 0.6381 1
0.0207 0.5366 0.5481
0.0227 0.3275 0.3275
0.019 0.6382 1
0.04 0.4141 0.4139
0.0391 0.6185 0.927
0.0232 0.4316 0.4299
0.0187 0.251 0.251
0.0199 0.2559 1
0.043 0.2512 0.4804
0.0183 0.5004 0.536
0.0209 0.6078 0.9821
0.0802 0.3534 0.3532
0.0194 0.617 1
0.0398 0.3117 0.3117
0.0439 0.3155 0.3155
0.0201 0.2532 0.2445
0.0588 0.2848 0.2845
0.1514 0.6008 1
0.0182 0.6129 1
0.0199 0.5375 0.5381
0.0577 0.6715 0.6709
0.0091 0.3415 0.6164
0.0214 0.3439 1
0.0232 0.5855 1
0.0183 0.3141 1
0.0227 0.262 0.262
0.0227 0.579 0.7431
0.0182 0.2543 0.2569
0.0201 0.5757 1
0.0438 0.4754 0.4754
0.0204 0.579 0.7407
0.0192 0.2732 0.2732
0.0196 0.2593 0.2752
0.0227 0.3211 0.3183
0.0227 0.2581 0.2579
0.0218 0.6084 1
0.0397 0.2906 0.2906
0.0193 0.3988 0.398
0.0195 0.324 0.3975
0.0227 0.3878 0.3878
0.0671 0.297 0.297
0.02 0.3597 0.3597
0.0215 0.3376 0.6139
0.0231 0.6308 0.6593
0.0379 0.6421 0.8035
0.0227 0.6445 1
0.0183 0.3201 0.3201
0.0211 0.5855 1
0.0227 0.2589 0.2589
0.0203 0.3884 0.3884
0.019 0.6314 1
0.0578 0.3502 0.8027
1.3752 0.5622 1
0.0198 0.2617 0.2617
0.0189 0.6281 1
0.0372 0.4367 1
0.0183 0.3859 0.435
0.0618 0.5565 0.5565
0.0191 0.3308 0.3308
0.0191 0.4165 0.4144
0.0196 0.5821 0.5821
0.0227 0.4609 0.6674
0.0388 0.4411 0.7038
0.0221 0.6264 0.8299
0.019 0.39 0.3893
0.0129 0.2638 0.2706
0.0212 0.2569 0.8559
0.0624 0.5924 1
0.0207 0.4156 0.608
0.0211 0.6265 0.6265
0.0242 0.2811 0.281
0.0428 0.6258 0.8496
0.0188 0.5314 0.5314
0.0397 0.3497 0.3497
0.0182 0.45 0.45
0.0595 0.3208 0.807
0.0194 0.6114 1
0.0221 0.6147 1
0.039 0.4352 0.6151
0.0186 0.4502 0.4502
0.0576 0.6424 1
0.0186 0.3172 0.5638
0.0183 0.3597 0.5222
0.0383 0.2696 0.2696
0.0227 0.5516 1
0.0227 0.5797 1
0.0227 0.3439 1
0.0194 0.2655 0.2648
0.0227 0.2595 0.2587
1.0254 0.618 1
0.0187 0.2529 0.3533
0.0186 0.471 0.552
0.0154 0.2855 0.2855
0.0227 0.4852 0.4767
0.0227 0.3435 0.3434
0.0201 0.2707 0.3492
0.0396 0.4579 0.8231
0.0196 0.579 1
0.0205 0.5375 0.5375
0.0216 0.2602 0.6918
0.0227 0.2532 0.2493
0.0183 0.2727 0.272
0.0227 0.628 1
0.0196 0.2548 0.2548
0.0749 0.554 0.5538
0.0934 0.6241 1
0.0206 0.2687 0.4638
0.0182 0.5857 1
0.0385 0.6389 0.7552
0.0188 0.412 1
0.0198 0.4027 0.4544
0.0191 0.367 1
0.0208 0.384 0.384
0.0204 0.2613 0.2613
0.0369 0.4571 0.4878
0.0208 0.6122 1
0.0217 0.3189 0.5392
0.0199 0.6235 1
0.0224 0.3752 0.3552
0.0215 0.2687 0.2687
0.041 0.4602 0.5413
0.0396 0.4878 0.9707
0.0403 0.4032 0.5741
0.0602 0.3611 0.8783
0.0227 0.6254 1
0.0211 0.3247 0.3994
0.0417 0.2518 0.2512
0.0367 0.6384 1
0.0232 0.6199 1
0.0227 0.6301 0.6735
0.0227 0.261 0.2603
0.0226 0.334 0.4476
0.0216 0.2585 0.2418
0.02 0.3908 0.4324
0.0191 0.6039 0.8431
0.0192 0.2632 0.2632
0.0182 0.5972 0.5968
0.0231 0.4396 0.4344
0.0207 0.3968 0.5507
0.0183 0.3357 0.4169
0.0216 0.4844 0.4834
0.0193 0.5405 0.5405
0.0185 0.2551 0.2551
0.0232 0.629 1
0.0187 0.2661 0.2661
0.0182 0.4388 0.8746
0.0195 0.4502 0.4489
0.0182 0.4243 0.4159
0.0204 0.4336 0.431
0.1003 0.2634 0.2634
0.0225 0.629 1
0.0204 0.3601 0.3601
0.041 0.2616 0.2616
0.0212 0.6289 1
0.0203 0.2861 0.2861
0.0228 0.6225 1
0.0194 0.3034 0.2982
0.0227 0.5824 1
0.0227 0.4223 1
0.0407 0.4036 0.492
0.0189 0.3752 0.3997
0.0206 0.635 1
0.021 0.6468 1
0.0185 0.4462 0.4462
0.0227 0.6327 1
0.0183 0.6068 0.7559
0.0331 0.3077 0.3077
0.0211 0.2505 1
0.075 0.7391 0.8926
0.0191 0.6274 1
0.0182 0.3537 1
0.0223 0.2675 0.2892
0.0369 0.4571 0.4878
0.0442 0.5924 1
0.0213 0.2604 0.3016
0.0227 0.4535 0.45
0.0188 0.3968 0.5804
0.0238 0.5077 0.5057
0.0541 0.2669 0.2669
0.0227 0.5882 0.5818
0.0189 0.4275 0.4275
0.0227 0.5686 1
0.0195 0.604 1
0.0215 0.264 1
0.381 0.6085 1
0.022 0.4592 0.6346
0.0186 0.2891 0.2891
0.0189 0.6298 0.6247
0.0229 0.5947 0.5908
0.0381 0.3809 0.4486
0.0219 0.2987 0.5321
0.9449 0.6132 1
0.0222 0.2609 0.2609
0.0503 0.5487 0.5474
0.0227 0.3891 0.3891
0.0388 0.3365 0.7686
0.0181 0.6315 1
0.0396 0.576 0.5732
0.0186 0.5672 0.8792
0.0217 0.6349 1
0.0224 0.2615 0.2615
0.0232 0.3257 0.3253
0.0379 0.6414 1
0.0188 0.4469 0.8383
0.0227 0.2554 0.2554
0.0636 0.3972 0.3972
0.039 0.419 0.8416
0.0227 0.6155 1
0.0188 0.3263 1
0.0227 0.6298 1
0.0227 0.5369 0.5369
0.0405 0.4353 0.4353
0.0224 0.3215 0.3215
0.044 0.2617 0.9594
0.0232 0.2589 0.2577
0.0212 0.4053 0.824
0.0189 0.415 1
0.0192 0.3759 0.3759
0.0227 0.2602 0.6584
0.0822 0.4547 0.5637
0.0196 0.5347 0.5347
0.0659 0.2959 0.2959
0.0217 0.3045 0.3045
0.0385 0.6351 1
0.0382 0.6402 1
0.02 0.2619 0.2548
0.0947 0.4634 0.4634
0.0192 0.2708 0.2691
0.0183 0.6213 0.7499
0.0524 0.6006 1
0.0202 0.4882 0.4882
0.0225 0.2626 0.6177
0.0186 0.3172 0.5638
0.0582 0.2673 0.267
0.0588 0.2712 0.269
0.0399 0.6316 1
0.0216 0.6389 1
0.0223 0.313 0.313
0.0219 0.3873 0.5518
0.022 0.5752 1
0.0227 0.579 1
0.0408 0.5943 0.5943
0.0618 0.5565 0.5565
0.0183 0.2595 0.2589
0.0208 0.2505 0.4491
0.0374 0.4558 0.5368
0.0227 0.6228 1
0.0191 0.2574 0.3739
0.0185 0.5786 0.5705
0.0192 0.5902 1
0.0197 0.3936 0.7946
0.0189 0.2724 0.2724
0.0235 0.386 0.397
0.0395 0.2548 0.2548
0.0186 0.3172 0.5638
0.0227 0.4031 1
0.0211 0.2513 0.2474
0.0204 0.2986 0.5563
0.0227 0.4409 0.4719
0.0219 0.3077 1
0.0379 0.4301 0.4971
0.0197 0.2691 0.2686
0.0231 0.2745 0.2745
0.0232 0.637 1
0.057 0.268 0.268
0.0227 0.3243 0.3242
0.0227 0.5948 1
0.2045 0.4448 0.4448
0.0389 0.3848 0.4578
0.0383 0.6346 1
0.0227 0.3987 0.3974
0.0587 0.6147 0.6733
0.0193 0.5329 0.5329
0.0203 0.3383 0.5127
0.0227 0.6014 1
0.0624 0.5941 1
0.0189 0.257 0.2526
0.0195 0.5387 0.5387
1.0623 0.6129 1
0.0168 0.3789 0.3777
0.0182 0.6291 1
0.0227 0.2709 1
0.0194 0.3345 0.4599
0.0407 0.4356 0.435
0.0205 0.4419 0.4417
0.0188 0.3281 0.4602
0.0189 0.6254 1
0.0394 0.3803 0.3803
0.0206 0.6172 1
0.0186 0.6298 1
0.02 0.3301 0.3182
0.4695 0.616 1
0.0545 0.258 0.3572
0.0232 0.2639 0.2596
0.0217 0.2829 0.2829
0.0578 0.3407 0.4466
0.0195 0.2601 0.2585
0.0379 0.4733 0.8075
0.0431 0.2664 0.2663
0.0227 0.6408 1
0.0373 0.3894 0.4639
0.0189 0.6329 1
0.0182 0.6112 1
0.0199 0.2749 0.2749
0.0183 0.3016 0.3071
0.0227 0.6213 1
0.0208 0.2815 0.7673
0.0206 0.2957 0.7966
0.0199 0.2711 0.2711
0.0232 0.3163 0.3613
0.0214 0.2807 0.2746
0.0409 0.4074 0.4037
0.075 0.2633 0.2633
0.0212 0.3897 0.6519
0.0218 0.2862 0.2823
0.0227 0.4106 0.4806
0.0232 0.6404 1
0.0392 0.4537 0.4537
0.0227 0.6404 1
0.0231 0.2609 1
0.0202 0.3468 0.3915
0.0182 0.6355 0.8246
0.0227 0.2584 0.2584
0.0215 0.3914 1
0.0197 0.5672 1
1.3292 0.6113 1
0.0618 0.5565 0.5565
0.0193 0.2632 0.2764
0.0192 0.4513 1
0.0198 0.2629 0.2621
0.0227 0.6215 1
0.0193 0.2574 1
0.0386 0.6636 0.6762
0.0232 0.2619 0.2611
0.0209 0.5443 0.5443
0.0407 0.5057 1
0.0379 0.2842 0.2821
0.0193 0.2603 0.2603
0.0225 0.4605 0.4582
0.0227 0.6014 1
0.1064 0.4649 0.5111
0.0206 0.278 0.2761
0.0194 0.2532 0.2532
0.0217 0.2987 0.2987
0.0579 0.3489 0.3489
0.0232 0.3066 0.3045
0.0227 0.2589 0.2581
0.0203 0.3965 0.4987
0.0227 0.2655 0.2648
0.0225 0.2582 0.5485
0.0227 0.4036 0.45
0.0199 0.4311 1
0.0189 0.5279 0.524
0.038 0.4697 0.756
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