pI: 8.4611 |
Length (AA): 291 |
MW (Da): 33415 |
Paralog Number:
3
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 2
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There is 1 model calculated for this protein. More info on
this model, including the
model itself is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
24 | 261 | 5kym (A) | 8 | 243 | 23.00 | 0 | 1 | 1.11657 | -0.26 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Ortholog group members (OG5_126904)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT4G30580 | 1-acyl-sn-glycerol-3-phosphate acyltransferase 1 |
Babesia bovis | BBOV_II006950 | acyltransferase family protein |
Brugia malayi | Bm1_13890 | Acyltransferase family protein |
Candida albicans | CaO19.250 | potential acyltransferase similar to S. cerevisiae SLC1 (YDL052C) 1-acylglycerol-3-phosphate O-acyltransferase involved in sphin |
Candida albicans | CaO19.7881 | potential acyltransferase similar to S. cerevisiae SLC1 (YDL052C) 1-acylglycerol-3-phosphate O-acyltransferase involved in sphin |
Caenorhabditis elegans | CELE_F59F4.4 | Protein ACL-1 |
Caenorhabditis elegans | CELE_T06E8.1 | Protein ACL-2, isoform B |
Cryptosporidium hominis | Chro.80165 | hypothetical protein |
Cryptosporidium parvum | cgd8_1400 | glycerol-3-phosphate acyltransferase family, possible plant origin, possible signal peptide plus 2 transmembrane domains |
Chlamydia trachomatis | CT_453 | glycerol-3-phosphate acyltransferase |
Dictyostelium discoideum | DDB_G0291332 | hypothetical protein |
Drosophila melanogaster | Dmel_CG3812 | CG3812 gene product from transcript CG3812-RB |
Escherichia coli | b3018 | 1-acyl-sn-glycerol-3-phosphate acyltransferase |
Echinococcus granulosus | EgrG_000101200 | Msx-like |
Echinococcus granulosus | EgrG_000234000 | Phospholipid glycerol acyltransferase |
Echinococcus granulosus | EgrG_000234300 | 1 acyl sn glycerol 3 phosphate acyltransferase |
Echinococcus granulosus | EgrG_000233900 | 1 acyl sn glycerol 3 phosphate acyltransferase |
Echinococcus multilocularis | EmuJ_000234000 | Phospholipid glycerol acyltransferase |
Echinococcus multilocularis | EmuJ_000234300 | 1 acyl sn glycerol 3 phosphate acyltransferase |
Echinococcus multilocularis | EmuJ_000233900 | 1 acyl sn glycerol 3 phosphate acyltransferase |
Echinococcus multilocularis | EmuJ_000101200 | homeobox |
Homo sapiens | ENSG00000204310 | 1-acylglycerol-3-phosphate O-acyltransferase 1 |
Homo sapiens | ENSG00000169692 | 1-acylglycerol-3-phosphate O-acyltransferase 2 |
Leishmania braziliensis | LbrM.32.2150 | 1-acyl-sn-glycerol-3-phosphateacyltransferase-like protein, putative |
Leishmania donovani | LdBPK_322070.1 | 1-acyl-sn-glycerol-3-phosphateacyltransferase-l ik eprotein, putative |
Leishmania infantum | LinJ.32.2070 | 1-acyl-sn-glycerol-3-phosphateacyltransferase-like protein, putative |
Leishmania major | LmjF.32.1960 | 1-acyl-sn-glycerol-3-phosphateacyltransferase-like protein, putative |
Leishmania mexicana | LmxM.31.1960 | 1-acyl-sn-glycerol-3-phosphateacyltransferase-like protein, putative |
Loa Loa (eye worm) | LOAG_14124 | hypothetical protein |
Loa Loa (eye worm) | LOAG_08437 | acyltransferase |
Loa Loa (eye worm) | LOAG_04757 | hypothetical protein |
Loa Loa (eye worm) | LOAG_14472 | hypothetical protein |
Mycobacterium leprae | ML1245 | POSSIBLE TRANSMEMBRANE PHOSPHOLIPID BIOSYNTHESIS BIFUNCTIONAL ENZYME PLSC: PUTATIVE L-3-PHOSPHOSERINE PHOSPHATASE (O-PHOSPHOSERI |
Mus musculus | ENSMUSG00000034254 | 1-acylglycerol-3-phosphate O-acyltransferase 1 (lysophosphatidic acid acyltransferase, alpha) |
Mus musculus | ENSMUSG00000026922 | 1-acylglycerol-3-phosphate O-acyltransferase 2 (lysophosphatidic acid acyltransferase, beta) |
Mycobacterium tuberculosis | Rv2182c | 1-acylglycerol-3-phosphate O-acyltransferase |
Mycobacterium tuberculosis | Rv2483c | Possible transmembrane phospholipid biosynthesis bifunctional enzyme PlsC: putative L-3-phosphoserine phosphatase (O-phosphoseri |
Mycobacterium ulcerans | MUL_3764 | bifunctional transmembrane phospholipid biosynthesis enzyme PlsC |
Mycobacterium ulcerans | MUL_3537 | 1-acylglycerol-3-phosphate O-acyltransferase |
Neospora caninum | NCLIV_017010 | Lysophosphatidic acid acyltransferase, related |
Neospora caninum | NCLIV_006550 | hypothetical protein |
Oryza sativa | 4349006 | Os10g0497100 |
Oryza sativa | 4337061 | Os04g0625200 |
Plasmodium berghei | PBANKA_1308200 | 1-acyl-sn-glycerol-3-phosphate acyltransferase, putative |
Plasmodium falciparum | PF3D7_1444300 | 1-acyl-sn-glycerol-3-phosphate acyltransferase, putative |
Plasmodium knowlesi | PKNH_1238000 | 1-acyl-sn-glycerol-3-phosphate acyltransferase, putative |
Plasmodium vivax | PVX_118280 | 1-acyl-sn-glycerol-3-phosphate acyltransferase, putative |
Plasmodium yoelii | PY01678 | 1-acyl-sn-glycerol-3-phosphate acyltransferase (ec 2.3.1.51) (1-agp acyltransferase) (1-agpat) (lysophosphatidic acid acyltransf |
Saccharomyces cerevisiae | YDL052C | 1-acylglycerol-3-phosphate O-acyltransferase SLC1 |
Schistosoma japonicum | Sjp_0214540 | ko:K00655 1-acyl-sn-glycerol-3-phosphate acyltransferase [EC2.3.1.51], putative |
Schistosoma mansoni | Smp_000075 | transcription factor |
Schistosoma mansoni | Smp_000070 | 1-acyl-sn-glycerol-3-phosphate o-acyltransferase |
Schmidtea mediterranea | mk4.011494.00 | |
Schmidtea mediterranea | mk4.011154.00 | 1-acyl-sn-glycerol-3-phosphate o-acyltransferase |
Trypanosoma brucei gambiense | Tbg972.11.17020 | 1-acyl-sn-glycerol-3-phosphate acyltransferase, putative |
Trypanosoma brucei | Tb927.11.15150 | 1-acyl-sn-glycerol-3-phosphate acyltransferase, putative |
Trypanosoma congolense | TcIL3000.11.15320 | 1-acyl-sn-glycerol-3-phosphate acyltransferase, putative |
Trypanosoma cruzi | TcCLB.509157.60 | 1-acyl-sn-glycerol-3-phosphate acyltransferase, putative |
Toxoplasma gondii | TGME49_297640 | acyltransferase domain-containing protein |
Toxoplasma gondii | TGME49_240860 | acyltransferase domain-containing protein |
Treponema pallidum | TP0361 | lysophosphatidic acid acyltransferase |
Theileria parva | TP02_0668 | hypothetical protein |
Wolbachia endosymbiont of Brugia malayi | Wbm0733 | 1-acyl-sn-glycerol-3-phosphate acyltransferase |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
mtu2216 | Mycobacterium tuberculosis | essential | nmpdr |
Tb11.01.6800 | Trypanosoma brucei | no significant loss or gain of fitness in bloodstream forms (3 days) | alsford |
Tb11.01.6800 | Trypanosoma brucei | no significant loss or gain of fitness in bloodstream forms (6 days) | alsford |
Tb11.01.6800 | Trypanosoma brucei | significant loss of fitness in procyclic forms | alsford |
Tb11.01.6800 | Trypanosoma brucei | significant loss of fitness in differentiation of procyclic to bloodstream forms | alsford |
b3018 | Escherichia coli | essential | goodall |
TGME49_240860 | Toxoplasma gondii | Probably essential | sidik |
TGME49_297640 | Toxoplasma gondii | Probably essential | sidik |
TGME49_240860 | Toxoplasma gondii | Probably non-essential | sidik |
TGME49_297640 | Toxoplasma gondii | Probably non-essential | sidik |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
Species | Known druggable target | Linked compounds | Reference |
---|---|---|---|
Homo sapiens | 1-acylglycerol-3-phosphate O-acyltransferase 2 | Compounds | References |