Detailed view for EgrG_000991800

Basic information

TDR Targets ID: 593844
Echinococcus granulosus, PHD finger protein rhinoceros

Source Database / ID:  GeneDB

pI: 7.8219 | Length (AA): 671 | MW (Da): 75535 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF13831   PHD-finger
PF13832   PHD-zinc-finger like domain

Gene Ontology

Mouse over links to read term descriptions.
No GO information for this protein.

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 4 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
137 190 4qf3 (A) 1929 1982 30.00 0 0.85 0.469377 -1.05
142 308 5dag (A) 25 200 45.00 0 1 0.654882 0.07
144 186 5wxh (A) 869 914 33.00 0.96 0.92 0.477083 -0.58
244 306 2lq6 (A) 318 389 48.00 0.0000024 0.56 0.38389 0.99

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_129599)

Species Accession Gene Product
Brugia malayi Bm1_56025   PHD-finger family protein
Caenorhabditis elegans CELE_Y53G8AR.2   Protein PHF-15, isoform B
Drosophila melanogaster Dmel_CG7036   rhinoceros
Echinococcus granulosus EgrG_000991800   PHD finger protein rhinoceros
Echinococcus multilocularis EmuJ_000991800   PHD finger protein rhinoceros
Homo sapiens ENSG00000077684   jade family PHD finger 1
Homo sapiens ENSG00000102221   jade family PHD finger 3
Homo sapiens ENSG00000043143   jade family PHD finger 2
Loa Loa (eye worm) LOAG_07321   PHD-finger family protein
Mus musculus ENSMUSG00000037315   jade family PHD finger 3
Mus musculus ENSMUSG00000020387   jade family PHD finger 2
Mus musculus ENSMUSG00000025764   jade family PHD finger 1
Schistosoma japonicum Sjp_0040230   expressed protein
Schistosoma japonicum Sjp_0130790   PHD finger protein rhinoceros, putative
Schistosoma mansoni Smp_137970   hypothetical protein
Schmidtea mediterranea mk4.001839.04  
Schmidtea mediterranea mk4.001839.05  
Schmidtea mediterranea mk4.008475.00  
Wolbachia endosymbiont of Brugia malayi Wbm0767   hypothetical protein

Essentiality

EgrG_000991800 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
CELE_Y53G8AR.2 Caenorhabditis elegans larval lethal wormbase
Show/Hide essentiality data references
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.


Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets

Obtained from network model

Ranking Plot


Putative Drugs List


Compound Raw Global Species
0.0205 0.2752 0.2894
0.0093 0.2537 0.2485
0.0182 0.2851 0.2852
0.0118 0.2755 0.2755
0.0669 0.2867 0.2791
0.0723 0.2871 0.2812
0.0653 0.2825 0.2806
0.0124 0.251 0.2736
0.0213 0.2884 0.2881
0.0723 0.2871 0.2812
0.0563 0.2909 0.2907
0.0163 0.2852 0.2852
0.0573 0.2559 0.2553
0.0563 0.2909 0.2907
0.0155 0.2518 0.2518
0.0661 0.2861 0.2842
0.0229 0.2656 0.2656
0.0179 0.2611 0.2611
0.0061 0.2651 0.2651
0.0654 0.286 0.284
0.065 0.2601 0.2852
0.0119 0.2524 0.2499
0.0086 0.2759 0.2754
0.0723 0.2871 0.2812
0.0059 0.2747 0.2747
0.0176 0.2789 0.2789
0.0035 0.2698 0.2698
0.0148 0.258 0.258
0.0595 0.2845 0.2832
0.021 0.2894 0.2877
0.0183 0.2861 0.2861
0.0633 0.2923 0.2921
0.0223 0.26 0.2575
0.0563 0.2909 0.2907
0.0563 0.2909 0.2907
0.0157 0.2657 0.2683
0.0691 0.2869 0.2848
0.0122 0.2856 0.2856
0.0094 0.2714 0.2294
0.0698 0.2931 0.2931
0.0464 0.2786 0.2758
0.0223 0.26 0.2575
0.0669 0.2886 0.2859
0.0785 0.2704 0.2883
0.015 0.2674 0.2635
0.0618 0.2871 0.2871
0.0098 0.2791 0.2509
0.0216 0.2618 0.2593
0.0633 0.2923 0.2921
0.0181 0.2807 0.2869
0.0035 0.2698 0.2698
0.0723 0.2871 0.2812
0.0545 0.2643 0.2841
0.0785 0.2704 0.2883
0.0664 0.2857 0.2793
0.0123 0.2765 0.267
0.0698 0.2931 0.2931
0.0159 0.2625 0.2616

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

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User comments

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Gene identifier EgrG_000991800 (Echinococcus granulosus), PHD finger protein rhinoceros
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