Detailed view for EgrG_000348200

Basic information

TDR Targets ID: 593882
Echinococcus granulosus, Down syndrome cell adhesion molecule
Source Database / ID:  GeneDB

pI: 7.6946 | Length (AA): 2827 | MW (Da): 311641 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 3

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00041   Fibronectin type III domain
PF13927   Immunoglobulin domain

Gene Ontology

Mouse over links to read term descriptions.
GO:0005515   protein binding  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 11 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
3 87 1cvs (D) 253 355 7.00 0.53 0 -0.116333 0.82
98 1080 3dmk (A) 16 755 26.00 0.000000000092 1 0.120318 1.88
386 450 5b21 (A) 67 130 33.00 0.24 0.29 0.273593 -0.41
430 565 1cs6 (A) 265 373 36.00 0.0012 0.68 0.0307075 1.66
468 575 2ij0 (E) 4 107 18.00 0 0.41 0.036803 0.26
961 1590 4pbx (A) 91 594 29.00 0 1 0.103451 1.6
1265 1368 5n48 (B) 1267 1356 26.00 0 0.54 0.168388 -1.06
1276 1368 5g15 (B) 13 96 25.00 0 0.98 0.201497 -0.59
1279 1376 2ekj (A) 20 102 37.00 0.22 1 0.337266 -0.52
1493 1606 4hlj (A) 768 882 39.00 0.00000018 0.98 0.490925 -0.72
1500 1599 4n68 (A) 875 972 30.00 0 1 0.370973 -1.05

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_128592)

Species Accession Gene Product
Drosophila melanogaster Dmel_CG17800   Down syndrome cell adhesion molecule 1
Drosophila melanogaster Dmel_CG31190   Down syndrome cell adhesion molecule 3
Drosophila melanogaster Dmel_CG42256   Down syndrome cell adhesion molecule 2
Drosophila melanogaster Dmel_CG42330   Down syndrome cell adhesion molecule 4
Echinococcus granulosus EgrG_000348200   Down syndrome cell adhesion molecule
Echinococcus multilocularis EmuJ_000348200   Down syndrome cell adhesion molecule
Echinococcus multilocularis EmuJ_000554200   fibronectin type III domain-containing protein
Homo sapiens ENSG00000171587   Down syndrome cell adhesion molecule
Homo sapiens ENSG00000177103   Down syndrome cell adhesion molecule like 1
Mus musculus ENSMUSG00000032087   Down syndrome cell adhesion molecule like 1
Mus musculus ensembl-mmu:ENSMUSG00000050272   Down syndrome cell adhesion molecule
Schistosoma japonicum Sjp_0039080   expressed protein
Schistosoma japonicum Sjp_0039070   Down syndrome cell adhesion molecule precursor, putative
Schistosoma mansoni Smp_164270   cell adhesion molecule
Schmidtea mediterranea mk4.001665.08  
Schmidtea mediterranea mk4.001665.06   Putative cell adhesion molecule

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model

Ranking Plot

Putative Drugs List

Compound Raw Global Species
0.012 0.7362 0.7362
0.0181 0.2727 0.2508
0.0159 0.2996 0.2973
0.0219 0.4579 0.4491
0.0079 0.4609 0.4609
0.0374 0.7576 0.7576
0.036 0.4119 0.4119
0.0471 0.341 0.3405
0.0378 0.586 0.586
0.0272 0.706 0.706
0.0461 0.2819 0.2813
0.0488 0.3798 0.3794
0.0132 0.2972 0.2972
0.0095 0.3502 0.3502
0.036 0.4119 0.4119
0.0156 0.6042 0.6042
0.0193 0.4477 0.4449
0.0475 0.706 0.706
0.0081 0.2507 0.2456
0.022 0.257 0.2565
0.0048 0.432 0.432
0.0098 0.2712 0.269
0.022 0.257 0.2565
0.012 0.7362 0.7362
0.0255 0.706 0.706
0.0089 0.442 0.8994
0.0114 0.6153 0.3459
0.0306 0.4883 0.4883
0.045 0.3045 0.3045
0.0347 0.7081 0.0359
0.036 0.4119 0.4119
0.0255 0.706 0.706
0.0156 0.6042 0.6042
0.0039 0.3299 0.3181
0.0251 0.7407 0.7407
0.0312 0.5397 0
0.017 0.2614 0.7011
0.0084 0.6788 0.6788
0.0302 0.2891 0.2891
0.0343 0.706 0.706
0.0271 0.2673 0.2356
0.045 0.3045 0.3045
0.0448 0.7636 0.7636
0.0274 0.4685 0.4685
0.0414 0.6115 0.6115
0.037 0.706 0.706
0.011 0.4641 0.4367
0.00858882 0.288628 0.198153
0.0207 0.4541 0.4467
0.0116 0.6967 0.6967
0.0194 0.3524 0.2119
0.0083 1 0.5
0.0274 0.267 0.2366
0.0266 0.2855 0.567
0.0155 0.3568 0.706
0.043 0.5151 0.5151
0.0374 0.7576 0.7576
0.0034 0.2581 0.2581
0.0146 0.4032 0.4032
0.0403 0.706 0.706
0.0111 0.334 1
0.0212 0.2754 0.2754
0.045 0.3045 0.3045
0.0184 0.706 0.706
0.0178 0.5983 0
0.0009 0.5 0.5
0.0223 0.4639 0.4639
0.045 0.3045 0.3045
0.02 0.7068 0.706
0.0274 0.267 0.2366
0.036 0.4119 0.4119
0.0331 0.4032 0.4032
0.0223 0.4639 0.4639
0.0378 0.586 0.586
0.0461 0.2819 0.2813
0.00858882 0.288628 0.198153
0.036 0.4119 0.4119
0.0461 0.2819 0.2813
0.0017 0.252 0.1982
0.0343 0.706 0.706
0.0362 0.2642 0.2325
0.0338 0.7566 0.7382
0.045 0.3045 0.3045
0.0461 0.2819 0.2813
0.0081 0.2507 0.2456
0.0104 0.8804 0.8611
0.0306 0.5177 0.5177
0.0084 0.6788 0.6788
0.00858882 0.288628 0.198153
0.045 0.3045 0.3045
0.0236 0.2618 0.2221
0.045 0.3045 0.3045
0.0324 0.4032 0.4032
0.0016 1 0.5
0.0129 0.3276 0.3276
0.0334 0.4633 0.4633
0.045 0.3045 0.3045
0.0237 0.3038 0.2891
0.0178 0.5983 0
0.0351 0.6072 0
0.0164 0.7647 0.7647
0.0313 0.5953 0.5953
0.0331 0.5087 0.5087
0.0414 0.6115 0.6115
0.0328 0.5101 0.5085
0.0216 0.706 0.706
0.0089 0.4623 0.477
0.0336 0.3462 0.4786
0.0048 0.4176 0.4167
0.0089 0.442 0.8994
0.0271 0.3613 0.7611
0.008 0.4641 0
0.0471 0.341 0.3405
0.021 0.4799 0.4799
0.0204 0.2891 0.2891
0.021 0.4799 0.4799
0.0334 0.4633 0.4633
0.0251 0.7407 0.7407
0.0219 0.4579 0.4491

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

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User comments

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Gene identifier EgrG_000348200 (Echinococcus granulosus), Down syndrome cell adhesion molecule
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