Detailed view for EgrG_001035600

Basic information

TDR Targets ID: 593936
Echinococcus granulosus, pseudouridine metabolizing bifunctional protein
Source Database / ID:  GeneDB

pI: 7.9641 | Length (AA): 698 | MW (Da): 74505 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00294   pfkB family carbohydrate kinase
PF04227   Indigoidine synthase A like protein

Gene Ontology

Mouse over links to read term descriptions.
GO:0016798   hydrolase activity, acting on glycosyl bonds  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 5 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
34 339 4gim (A) 7 308 43.00 0 1 1.0643 -1.37
354 692 3kzh (A) 6 315 18.00 0 1 0.643073 0.14
356 633 2nwh (A) 3 253 28.00 0.0000003 0.99 0.484081 1.05
356 690 2qcv (A) 12 328 13.00 0 0.86 0.567343 0.2
542 660 1vi9 (A) 137 250 22.00 0.017 0.46 0.253887 -0.16

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_129376)

Species Accession Gene Product
Arabidopsis thaliana AT1G50510   indigoidine synthase A-like protein
Candida albicans CaO19.6187   potential pfkB family carbohydrate kinase similar to S. pombe SPBC1861.05
Candida albicans CaO19.6185   good match to Indigoidine synthase A like protein involved in pigment biosynthesis (pathogenicity, protection from oxidative str
Caenorhabditis elegans CELE_T24C12.3   Protein T24C12.3
Dictyostelium discoideum DDB_G0268118   hypothetical protein
Drosophila melanogaster Dmel_CG2794   CG2794 gene product from transcript CG2794-RA
Escherichia coli b2165   pseudouridine 5'-phosphate glycosidase
Echinococcus granulosus EgrG_001035600   pseudouridine metabolizing bifunctional protein
Entamoeba histolytica EHI_149860   Hypothetical protein T24C12.3, putative
Echinococcus multilocularis EmuJ_001035600   pseudouridine metabolizing bifunctional protein
Giardia lamblia GL50803_15077   Hypothetical protein
Oryza sativa 4345970   Os08g0504400

Essentiality

EgrG_001035600 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
b2165 Escherichia coli non-essential goodall
Show/Hide essentiality data references
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier EgrG_001035600 (Echinococcus granulosus), pseudouridine metabolizing bifunctional protein
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