Detailed view for PF3D7_0718300

Basic information

TDR Targets ID: 594
Plasmodium falciparum, cysteine repeat modular protein 2
Source Database / ID:  PlasmoDB   |   GeneDB   |   MPMP

pI: 8.3118 | Length (AA): 2543 | MW (Da): 296919 | Paralog Number: 1

Signal peptide: Y | GPI Anchor: N | Predicted trans-membrane segments: 10

Druggability Group : DG3

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF07699   Putative ephrin-receptor like

Gene Ontology

Mouse over links to read term descriptions.
GO:0020011   apicoplast  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 10 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
27 706 4wd9 (A) 161 985 18.00 0.014 0.8 0.0597007 1.96
1049 1133 4bk4 (B) 233 320 36.00 0.02 0.96 0.217225 0.53
1063 1132 3fl7 (A) 257 319 40.00 0.12 0.9 0.312327 0.86
2455 2540 4bwn (A) 259 344 7.00 0.91 0 0.164118 -0.82
569 923 3r4s (A) 867 1242 19.00 0.23 0.72 0.0886989 1.4
1049 1133 4bk4 (B) 233 320 35.00 0.063 0.9 0.188825 0.65
1063 1132 3fl7 (A) 257 319 38.00 0.37 0.49 0.226927 1.1
1435 1581 4bkf (A) 259 387 34.00 0.069 0.22 -0.0577943 1.58
2262 2475 4tql (A) 21 234 19.00 0.046 0.65 0.251253 -0.25
2334 2542 4tql (A) 9 217 12.00 0.08 0.02 0.240286 -0.56

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

Upregulation Percent Ranking Stage Dataset
Mid 40-60% percentile Sporozoite. Zanghi G
Upregulation Percent Ranking Stage Dataset
Lower 0-20% percentile intra-erythrocytic - 0 hs, intra-erythrocytic - 8 hs, intra-erythrocytic - 16 hs, intra-erythrocytic - 24 hs, intra-erythrocytic - 32 hs, intra-erythrocytic - 40 hs, intra-erythrocytic - 48 hs, Oocyst, Ring, Female Gametocyte, Male Gametocyte. Otto TD Zanghi G Lasonder E
Show/Hide expression data references
  • Zanghi G A Specific PfEMP1 Is Expressed in P. falciparum Sporozoites and Plays a Role in Hepatocyte Infection.
  • Lasonder E Integrated transcriptomic and proteomic analyses of P. falciparum gametocytes. Molecular insight into sex-specific processes and translational repression.
  • Otto TD New insights into the blood-stage transcriptome of Plasmodium falciparum using RNA-Seq.

Orthologs

Ortholog group members (OG5_131558)

Species Accession Gene Product
Babesia bovis BBOV_III011730   GCC2 and GCC3 domain containing protein
Babesia bovis BBOV_III011740   GCC2 and GCC3 domain containing protein
Neospora caninum NCLIV_026200   hypothetical protein
Neospora caninum NCLIV_002550   hypothetical protein
Neospora caninum NCLIV_002790   hypothetical protein, conserved
Neospora caninum NCLIV_002800   hypothetical protein
Neospora caninum NCLIV_049760   hypothetical protein
Neospora caninum NCLIV_008250   hypothetical protein
Plasmodium berghei PBANKA_0615900   cysteine repeat modular protein 2
Plasmodium berghei PBANKA_0812400   cysteine repeat modular protein 1
Plasmodium falciparum PF3D7_0718300   cysteine repeat modular protein 2
Plasmodium falciparum PF3D7_0911300   cysteine repeat modular protein 1
Plasmodium knowlesi PKNH_0709300   cysteine repeat modular protein 1, putative
Plasmodium knowlesi PKNH_0313600   cysteine repeat modular protein 2, putative
Plasmodium vivax PVX_099005   cysteine repeat modular protein 1, putative
Plasmodium vivax PVX_096410   cysteine repeat modular protein 2, putative
Plasmodium yoelii PY00337   cysteine repeat modular protein 1 PbCRM1
Plasmodium yoelii PY05845   cysteine repeat modular protein 2 PbCRM2-related
Plasmodium yoelii PY05272   cysteine repeat modular protein 2 PbCRM2-related
Schmidtea mediterranea mk4.006064.03  
Schmidtea mediterranea mk4.001026.05  
Schmidtea mediterranea mk4.001381.04  
Schmidtea mediterranea mk4.013409.02  
Schmidtea mediterranea mk4.007371.00  
Schmidtea mediterranea mk4.019703.00  
Schmidtea mediterranea mk4.002956.02  
Schmidtea mediterranea mk4.031496.00  
Schmidtea mediterranea mk4.001023.02  
Schmidtea mediterranea mk4.000586.01  
Schmidtea mediterranea mk4.030760.01  
Schmidtea mediterranea mk4.011778.00  
Schmidtea mediterranea mk4.004995.01  
Schmidtea mediterranea mk4.021405.01  
Schmidtea mediterranea mk4.014798.01  
Schmidtea mediterranea mk4.005260.00  
Schmidtea mediterranea mk4.023739.00  
Schmidtea mediterranea mk4.009653.00  
Trypanosoma cruzi TcCLB.507967.10   hypothetical protein
Toxoplasma gondii TGME49_207880   hypothetical protein
Toxoplasma gondii TGME49_235183   PAN domain-containing protein
Toxoplasma gondii TGME49_253930   GCC2 and GCC3 domain-containing protein
Toxoplasma gondii TGME49_253920   hypothetical protein
Toxoplasma gondii TGME49_235187   hypothetical protein
Toxoplasma gondii TGME49_253925   zonadhesin family protein
Toxoplasma gondii TGME49_207865   GCC2 and GCC3 domain-containing protein
Toxoplasma gondii TGME49_207480   GCC2 and GCC3 domain-containing protein
Toxoplasma gondii TGME49_261080   kringle domain-containing protein
Toxoplasma gondii TGME49_207875   GCC2 and GCC3 domain-containing protein
Theileria parva TP01_1044   hypothetical protein
Theileria parva TP01_1042   hypothetical protein, conserved
Theileria parva TP01_1043   hypothetical protein, conserved

Essentiality

PF3D7_0718300 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
PBANKA_0615900 Plasmodium berghei Dispensable plasmo
PBANKA_0812400 Plasmodium berghei Dispensable plasmo
TGME49_253930 Toxoplasma gondii Essentiality uncertain sidik
TGME49_261080 Toxoplasma gondii Essentiality uncertain sidik
TGME49_207880 Toxoplasma gondii Essentiality uncertain sidik
TGME49_207865 Toxoplasma gondii Essentiality uncertain sidik
TGME49_253920 Toxoplasma gondii Essentiality uncertain sidik
TGME49_207480 Toxoplasma gondii Essentiality uncertain sidik
TGME49_235187 Toxoplasma gondii Essentiality uncertain sidik
TGME49_207875 Toxoplasma gondii Essentiality uncertain sidik
TGME49_235183 Toxoplasma gondii Essentiality uncertain sidik
TGME49_253925 Toxoplasma gondii Essentiality uncertain sidik
TGME49_253930 Toxoplasma gondii Probably non-essential sidik
TGME49_261080 Toxoplasma gondii Probably non-essential sidik
TGME49_207880 Toxoplasma gondii Probably non-essential sidik
TGME49_207865 Toxoplasma gondii Probably non-essential sidik
TGME49_253920 Toxoplasma gondii Probably non-essential sidik
TGME49_207480 Toxoplasma gondii Probably non-essential sidik
TGME49_235187 Toxoplasma gondii Probably non-essential sidik
TGME49_207875 Toxoplasma gondii Probably non-essential sidik
TGME49_235183 Toxoplasma gondii Probably non-essential sidik
TGME49_253925 Toxoplasma gondii Probably non-essential sidik
TGME49_253930 Toxoplasma gondii Probably essential sidik
TGME49_261080 Toxoplasma gondii Probably essential sidik
TGME49_207880 Toxoplasma gondii Probably essential sidik
TGME49_207865 Toxoplasma gondii Probably essential sidik
TGME49_253920 Toxoplasma gondii Probably essential sidik
TGME49_207480 Toxoplasma gondii Probably essential sidik
TGME49_235187 Toxoplasma gondii Probably essential sidik
TGME49_207875 Toxoplasma gondii Probably essential sidik
TGME49_235183 Toxoplasma gondii Probably essential sidik
TGME49_253925 Toxoplasma gondii Probably essential sidik
Show/Hide essentiality data references
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Druggability index (range: 0 to 1): 0.1

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

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Gene identifier PF3D7_0718300 (Plasmodium falciparum), cysteine repeat modular protein 2
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