pI: 5.2575 |
Length (AA): 1323 |
MW (Da): 146119 |
Paralog Number:
0
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 2
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 3 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
37 | 1265 | 4g1e (A) | 1 | 959 | 19.00 | 0 | 1 | 0.734049 | 1.37 |
57 | 679 | 3vi3 (A) | 16 | 517 | 34.00 | 0 | 1 | 0.387699 | 1.02 |
1265 | 1311 | 2knc (A) | 960 | 1006 | 45.00 | 0.0014 | 0.05 | 0.0706253 | 3.82 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Ortholog group members (OG5_129341)
Species | Accession | Gene Product |
---|---|---|
Brugia malayi | Bm1_03420 | Integrin alpha pat-2 precursor |
Caenorhabditis elegans | CELE_F54F2.1 | Protein PAT-2 |
Drosophila melanogaster | Dmel_CG9623 | inflated |
Echinococcus granulosus | EgrG_000215000 | integrin alpha 3 |
Echinococcus multilocularis | EmuJ_000215000 | integrin alpha 3 |
Homo sapiens | ENSG00000138448 | integrin, alpha V |
Homo sapiens | 8516 | integrin, alpha 8 |
Homo sapiens | ENSG00000161638 | integrin, alpha 5 (fibronectin receptor, alpha polypeptide) |
Homo sapiens | ENSG00000005961 | integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41) |
Loa Loa (eye worm) | LOAG_07837 | integrin alpha pat-2 |
Loa Loa (eye worm) | LOAG_08968 | hypothetical protein |
Loa Loa (eye worm) | LOAG_08969 | hypothetical protein |
Mus musculus | ENSMUSG00000027087 | integrin alpha V |
Mus musculus | ENSMUSG00000000555 | integrin alpha 5 (fibronectin receptor alpha) |
Mus musculus | ENSMUSG00000034664 | integrin alpha 2b |
Mus musculus | ENSMUSG00000026768 | integrin alpha 8 |
Schistosoma japonicum | Sjp_0037680 | IPR013513,Integrin alpha chain, C-terminal cytoplasmic region,domain-containing |
Schistosoma japonicum | Sjp_0037690 | ko:K06476 integrin alpha 2B, putative |
Schistosoma mansoni | Smp_126140 | integrin alpha |
Schmidtea mediterranea | mk4.001411.00 | Integrin alpha ina-1 |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
CELE_F54F2.1 | Caenorhabditis elegans | embryonic lethal | wormbase |
CELE_F54F2.1 | Caenorhabditis elegans | larval arrest | wormbase |
CELE_F54F2.1 | Caenorhabditis elegans | larval lethal | wormbase |
CELE_F54F2.1 | Caenorhabditis elegans | sterile | wormbase |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
Species | Known druggable target | Linked compounds | Reference |
---|---|---|---|
Homo sapiens | integrin, alpha 5 (fibronectin receptor, alpha polypeptide) | Compounds | References |
Homo sapiens | integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41) | Compounds | References |
Homo sapiens | integrin, alpha V | Compounds | References |