pI: 9.4718 |
Length (AA): 339 |
MW (Da): 37809 |
Paralog Number:
0
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 1
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 3 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
64 | 335 | 5gms (A) | 23 | 296 | 17.00 | 0.045 | 1 | 0.99776 | -0.21 |
85 | 140 | 5vem (A) | 324 | 380 | 41.00 | 0.062 | 0.16 | 0.257192 | 1.96 |
93 | 209 | 2e3j (A) | 10 | 122 | 19.00 | 0.046 | 0.97 | 0.677533 | -0.91 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Ortholog group members (OG5_131360)
Species | Accession | Gene Product |
---|---|---|
Brugia malayi | Bm1_12180 | Protein C20orf22 |
Caenorhabditis elegans | CELE_Y97E10AL.2 | Protein Y97E10AL.2 |
Drosophila melanogaster | Dmel_CG15111 | CG15111 gene product from transcript CG15111-RB |
Echinococcus granulosus | EgrG_000217800 | monoacylglycerol lipase abhd12 |
Echinococcus multilocularis | EmuJ_000217800 | monoacylglycerol lipase abhd12 |
Homo sapiens | ENSG00000100997 | abhydrolase domain containing 12 |
Loa Loa (eye worm) | LOAG_11300 | hypothetical protein |
Loa Loa (eye worm) | LOAG_15136 | hypothetical protein |
Loa Loa (eye worm) | LOAG_15821 | hypothetical protein |
Mus musculus | ENSMUSG00000032046 | abhydrolase domain containing 12 |
Onchocerca volvulus | OVOC6094 |
|
Onchocerca volvulus | OVOC6006 |
|
Schistosoma japonicum | Sjp_0205340 | IPR000073,Alpha/beta hydrolase fold-1;IPR002345,Lipocalin,domain-containing |
Schistosoma mansoni | Smp_010280 | family S9 unassigned peptidase (S09 family) |
Schmidtea mediterranea | mk4.022575.00 | |
Schmidtea mediterranea | mk4.022423.00 | |
Schmidtea mediterranea | mk4.020135.00 |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
Species | Known druggable target | Linked compounds | Reference |
---|---|---|---|
Homo sapiens | abhydrolase domain containing 12 | Compounds | References |
Mus musculus | abhydrolase domain containing 12 | Compounds | References |