pI: 6.563 |
Length (AA): 1347 |
MW (Da): 149088 |
Paralog Number:
0
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 11 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
1 | 173 | 5h68 (A) | 1 | 1031 | 33.00 | 0 | 1 | 0.458234 | -0.08 |
1 | 156 | 1e69 (A) | 1 | 145 | 34.00 | 0 | 1 | 0.281613 | 0.26 |
2 | 408 | 5xei (A) | 3 | 1059 | 29.00 | 0 | 1 | 0.488253 | 0.99 |
24 | 302 | 3qf7 (A) | 18 | 821 | 26.00 | 0.81 | 0.84 | 0.241227 | 0.65 |
292 | 1017 | 1tr2 (A) | 147 | 919 | 14.00 | 0.99 | 1 | 0.554775 | 0.86 |
486 | 718 | 4u4p (A) | 475 | 702 | 41.00 | 0 | 1 | 0.708777 | -1.14 |
1202 | 1338 | 2ppt (A) | 1 | 138 | 26.00 | 0.00000000002 | 1 | 0.435508 | -0.42 |
1244 | 1347 | 3f3q (A) | 0 | 103 | 51.00 | 0 | 1 | 0.812009 | -1.93 |
1245 | 1346 | 2voc (A) | 2 | 103 | 38.00 | 0 | 1 | 0.546524 | -0.99 |
1246 | 1346 | 4dss (B) | 2 | 103 | 50.00 | 0 | 1 | 0.812981 | -2 |
1294 | 1334 | 5j7d (G) | 51 | 91 | 34.00 | 0.72 | 0.82 | 0.310238 | 0.74 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Ortholog group members (OG5_127360)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT5G62410 | structural maintenance of chromosome 2 |
Arabidopsis thaliana | AT3G47460 | structural maintenance of chromosomes protein 2-2 |
Babesia bovis | BBOV_II001730 | smc family/structural maintenance of chromosome |
Brugia malayi | Bm1_43270 | SMC proteins Flexible Hinge Domain containing protein |
Candida albicans | CaO19.3623 | potential SMC chromosomal ATPase similar to S. cerevisiae SMC2 (YFR031C) nuclear condensin complex ATPase |
Candida albicans | CaO19.11106 | potential SMC chromosomal ATPase similar to S. cerevisiae SMC2 (YFR031C) nuclear condensin complex ATPase |
Caenorhabditis elegans | CELE_M106.1 | Protein MIX-1 |
Cryptosporidium hominis | Chro.40250 | SMC2 protein |
Cryptosporidium parvum | cgd4_2200 | SMC2 protein |
Dictyostelium discoideum | DDB_G0284499 | structural maintenance of chromosome protein |
Drosophila melanogaster | Dmel_CG10212 | CG10212 gene product from transcript CG10212-RA |
Echinococcus granulosus | EgrG_000602100 | structural maintenance of chromosomes protein 2 |
Entamoeba histolytica | EHI_049770 | mitotic chromosome and X-chromosome-associated protein, putative |
Echinococcus multilocularis | EmuJ_000602100 | structural maintenance of chromosomes protein 2 |
Giardia lamblia | GL50803_23185 | Hypothetical protein, similar to SMC2 |
Homo sapiens | ENSG00000136824 | structural maintenance of chromosomes 2 |
Leishmania braziliensis | LbrM.05.0410 | structural maintenance of chromosome (SMC), putative |
Leishmania donovani | LdBPK_050400.1 | structural maintenance of chromosome (SMC), putative |
Leishmania infantum | LinJ.05.0400 | structural maintenance of chromosome (SMC), putative |
Leishmania major | LmjF.05.0400 | structural maintenance of chromosome (SMC), putative |
Leishmania mexicana | LmxM.05.0400 | structural maintenance of chromosome (SMC), putative |
Loa Loa (eye worm) | LOAG_05577 | hypothetical protein |
Loa Loa (eye worm) | LOAG_12292 | hypothetical protein |
Loa Loa (eye worm) | LOAG_08510 | hypothetical protein |
Mus musculus | ENSMUSG00000028312 | structural maintenance of chromosomes 2 |
Mycobacterium tuberculosis | Rv2922c | Probable chromosome partition protein Smc |
Mycobacterium ulcerans | MUL_2033 | chromosome partition protein Smc |
Neospora caninum | NCLIV_006710 | SMC2 protein, related |
Oryza sativa | 4325020 | Os01g0904400 |
Plasmodium berghei | PBANKA_1416900 | structural maintenance of chromosomes protein 2, putative |
Plasmodium falciparum | PF3D7_1318400 | structural maintenance of chromosomes protein 2, putative |
Plasmodium knowlesi | PKNH_1419200 | structural maintenance of chromosomes protein 2, putative |
Plasmodium vivax | PVX_122740 | structural maintenance of chromosome 2, putative |
Plasmodium yoelii | PY01780 | protein mix-1, putative |
Saccharomyces cerevisiae | YFR031C | condensin subunit SMC2 |
Schistosoma japonicum | Sjp_0216510 | ko:K06674 structural maintenance of chromosome 2, putative |
Schistosoma japonicum | Sjp_0093150 | ko:K06674 structural maintenance of chromosome 2, putative |
Schistosoma mansoni | Smp_171710 | structural maintenance of chromosomes smc2 |
Schmidtea mediterranea | mk4.003369.02 | Structural maintenance of chromosomes protein 2 |
Schmidtea mediterranea | mk4.013535.00 | Mitotic chromosome and X-chromosome-associated protein mix-1 |
Trypanosoma brucei gambiense | Tbg972.10.12590 | structural maintenance of chromosome 2, putative |
Trypanosoma brucei | Tb11.v5.0811 | structural maintenance of chromosome 2, putative |
Trypanosoma brucei | Tb927.10.10340 | structural maintenance of chromosome 2, putative |
Trypanosoma congolense | TcIL3000_10_8800 | structural maintenance of chromosome 2, putative |
Trypanosoma cruzi | TcCLB.511633.60 | structural maintenance of chromosome (SMC), putative |
Toxoplasma gondii | TGME49_297800 | RecF/RecN/SMC N terminal domain-containing protein |
Theileria parva | TP04_0409 | condensin subunit, putative |
Trichomonas vaginalis | TVAG_313860 | condensin subunit Smc2 |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
Tb927.10.10340 | Trypanosoma brucei | no significant loss or gain of fitness in bloodstream forms (3 days) | alsford |
Tb927.10.10340 | Trypanosoma brucei | significant loss of fitness in bloodstream forms (6 days) | alsford |
Tb927.10.10340 | Trypanosoma brucei | no significant loss or gain of fitness in procyclic forms | alsford |
Tb927.10.10340 | Trypanosoma brucei | no significant loss or gain of fitness in differentiation of procyclic to bloodstream forms | alsford |
CELE_M106.1 | Caenorhabditis elegans | embryonic lethal | wormbase |
CELE_M106.1 | Caenorhabditis elegans | larval lethal | wormbase |
YFR031C | Saccharomyces cerevisiae | inviable | yeastgenome |
TGME49_297800 | Toxoplasma gondii | Probably essential | sidik |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.