Detailed view for EgrG_001091800

Basic information

TDR Targets ID: 594644
Echinococcus granulosus, 55 kDa erythrocyte membrane protein
Source Database / ID:  GeneDB

pI: 8.5622 | Length (AA): 622 | MW (Da): 69442 | Paralog Number: 1

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00595   PDZ domain (Also known as DHR or GLGF)
PF00625   Guanylate kinase

Gene Ontology

Mouse over links to read term descriptions.
GO:0005515   protein binding  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 5 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
9 134 4wyu (A) 72 191 33.00 0.44 0.99 0.205672 1.24
59 143 1y7n (A) 10 89 29.00 0 0.98 0.501856 -0.84
59 140 2e7k (A) 5 84 48.00 0.0000000000066 1 0.690933 -0.11
61 620 4wsi (A) 254 673 34.00 0 1 0.497422 2.41
61 145 1kwa (A) 488 572 42.00 0 1 0.696856 -0.58

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_131953)

Species Accession Gene Product
Brugia malayi Bm1_33725   Peripheral plasma membrane protein CASK
Brugia malayi Bm1_33715   CASK
Caenorhabditis elegans CELE_F17E5.1   Protein LIN-2, isoform B
Drosophila melanogaster Dmel_CG6703   CASK ortholog
Echinococcus granulosus EgrG_000826200   peripheral plasma membrane protein CASK
Echinococcus granulosus EgrG_001091800   55 kDa erythrocyte membrane protein
Echinococcus multilocularis EmuJ_001091800   55 kDa erythrocyte membrane protein
Echinococcus multilocularis EmuJ_000826200   peripheral plasma membrane protein CASK
Homo sapiens ENSG00000147044   calcium/calmodulin-dependent serine protein kinase (MAGUK family)
Loa Loa (eye worm) LOAG_08350   peripheral plasma membrane protein CASK
Mus musculus ENSMUSG00000031012   calcium/calmodulin-dependent serine protein kinase (MAGUK family)
Onchocerca volvulus OVOC2817  
Schistosoma japonicum Sjp_0099520   IPR000719,Protein kinase,domain-containing
Schistosoma japonicum Sjp_0019370   ko:K06103 calcium/calmodulin-dependent serine protein kinase, putative
Schistosoma japonicum Sjp_0095530   ko:K06103 calcium/calmodulin-dependent serine protein kinase, putative
Schistosoma japonicum Sjp_0102420   IPR000719,Protein kinase,domain-containing
Schistosoma japonicum Sjp_0101920   Peripheral plasma membrane protein CASK, putative
Schistosoma japonicum Sjp_0019390   Selenoprotein O, putative
Schistosoma japonicum Sjp_0074900   Calcium/calmodulin-dependent protein kinase, putative
Schistosoma japonicum Sjp_0123510   Peripheral plasma membrane protein CASK, putative
Schistosoma japonicum Sjp_0010060   Peripheral plasma membrane protein CASK, putative
Schistosoma japonicum Sjp_0134100   Selenoprotein O, putative
Schistosoma mansoni Smp_131690   MAGUK homolog
Schmidtea mediterranea mk4.019391.01  
Schmidtea mediterranea mk4.001239.06  
Schmidtea mediterranea mk4.012221.00  
Schmidtea mediterranea mk4.019259.00  

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Homo sapiens calcium/calmodulin-dependent serine protein kinase (MAGUK family) Compounds References
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model

Ranking Plot

Putative Drugs List

Compound Raw Global Species
0.0267 0.2508 0.3386
0.0044 0.2612 0.2895

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier EgrG_001091800 (Echinococcus granulosus), 55 kDa erythrocyte membrane protein
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