Detailed view for TP0158

Basic information

TDR Targets ID: 596130
Treponema pallidum, hypothetical protein
Source Database / ID:  KEGG  

pI: 6.912 | Length (AA): 228 | MW (Da): 26478 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00702   haloacid dehalogenase-like hydrolase

Gene Ontology

Mouse over links to read term descriptions.
GO:0016787   hydrolase activity  
GO:0008152   metabolic process  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 4 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
5 222 3nuq (A) 43 279 26.00 0 1 1.31564 -0.74
8 228 2hoq (A) 1 233 24.00 0 1 1.2698 -0.48
9 222 3mc1 (A) 2 215 17.00 0 0.77 1.1941 -0.8
91 192 2i6x (A) 90 191 33.00 0.21 0.3 0.534068 0.73

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_130972)

Species Accession Gene Product
Arabidopsis thaliana AT2G32150   haloacid dehalogenase-like hydrolase domain-containing protein
Arabidopsis thaliana AT5G59490   haloacid dehalogenase-like hydrolase (HAD) superfamily protein
Arabidopsis thaliana AT3G62040   haloacid dehalogenase-like hydrolase superfamily protein
Candida albicans CaO19.3922   similar to S. cerevisiae SDT1 (YGL224C) pyrimidine 5' nucleotidase and to PHM8 (YER037W)
Candida albicans CaO19.11404   similar to S. cerevisiae SDT1 (YGL224C) pyrimidine 5' nucleotidase and to PHM8 (YER037W)
Dictyostelium discoideum DDB_G0293862   haloacid dehalogenase-like hydrolase
Oryza sativa 4326398   Os01g0973000
Oryza sativa 4332401   Os03g0273800
Oryza sativa 4333827   Os03g0701200
Oryza sativa 9266306   Os03g0834050
Oryza sativa 4344018   Os07g0634400
Saccharomyces cerevisiae YER037W   Phm8p
Saccharomyces cerevisiae YGL224C   Sdt1p
Treponema pallidum TP0158   hypothetical protein

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

No user comments are available for this gene. Log in to add comments, or register.

Enter your comment

User ()
Gene identifier TP0158 (Treponema pallidum), hypothetical protein
Title for this comment
Comment