Detailed view for Rv0129c

Basic information

TDR Targets ID: 6065
Mycobacterium tuberculosis, Secreted antigen 85-C FbpC (85C) (antigen 85 complex C) (AG58C) (mycolyl transferase 85C) (fibronectin-binding protein C)

Source Database / ID:  Tuberculist 

pI: 6.2433 | Length (AA): 340 | MW (Da): 36771 | Paralog Number: 0

Signal peptide: Y | GPI Anchor: | Predicted trans-membrane segments: 1

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00756   Putative esterase

Gene Ontology

Mouse over links to read term descriptions.
No GO information for this protein.

Structural information

Modbase 3D models:

There are 2 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
5 326 3mga (A) 122 400 17.00 0 1 0.940759 0.21
47 328 5kwi (A) 1 282 99.99 0 1 2.15661 -2.39

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

  • 1DQY:
  • Resolution Method # Atoms # Residues Dep. Date Pub. Date Mod. Date
  • 1DQZ:
  • Resolution Method # Atoms # Residues Dep. Date Pub. Date Mod. Date
  • 1F0N:
  • Resolution Method # Atoms # Residues Dep. Date Pub. Date Mod. Date
  • 1F0P:
  • Resolution Method # Atoms # Residues Dep. Date Pub. Date Mod. Date
  • 1R88:
  • Resolution Method # Atoms # Residues Dep. Date Pub. Date Mod. Date
  • 1SFR:
  • Resolution Method # Atoms # Residues Dep. Date Pub. Date Mod. Date
  • 1VA5:
  • Resolution Method # Atoms # Residues Dep. Date Pub. Date Mod. Date
  • 3HRH:
  • Resolution Method # Atoms # Residues Dep. Date Pub. Date Mod. Date
  • 4MQL:
  • Resolution Method # Atoms # Residues Dep. Date Pub. Date Mod. Date
  • 4MQM:
  • Resolution Method # Atoms # Residues Dep. Date Pub. Date Mod. Date
  • 4QDO:
  • Resolution Method # Atoms # Residues Dep. Date Pub. Date Mod. Date
  • 4QDT:
  • Resolution Method # Atoms # Residues Dep. Date Pub. Date Mod. Date
  • 4QDU:
  • Resolution Method # Atoms # Residues Dep. Date Pub. Date Mod. Date
  • 4QDX:
  • Resolution Method # Atoms # Residues Dep. Date Pub. Date Mod. Date
  • 4QDZ:
  • Resolution Method # Atoms # Residues Dep. Date Pub. Date Mod. Date
  • 4QE3:
  • Resolution Method # Atoms # Residues Dep. Date Pub. Date Mod. Date
  • 4QEK:
  • Resolution Method # Atoms # Residues Dep. Date Pub. Date Mod. Date
  • 5KWI:
  • Resolution Method # Atoms # Residues Dep. Date Pub. Date Mod. Date
  • 5KWJ:
  • Resolution Method # Atoms # Residues Dep. Date Pub. Date Mod. Date
  • 5OCJ:
  • Resolution Method # Atoms # Residues Dep. Date Pub. Date Mod. Date
  • 5VNS:
  • Resolution Method # Atoms # Residues Dep. Date Pub. Date Mod. Date

Expression

Upregulation Percent Ranking Stage Dataset
Upper 80-100% percentile Dormant phase. hasan
Upregulation Percent Ranking Stage Dataset
Lower 20-40% percentile Dormant phase. murphy
Show/Hide expression data references
  • murphy Identification of gene targets against dormant phase Mycobacterium tuberculosis infections.
  • hasan Prioritizing genomic drug targets in pathogens: application to Mycobacterium tuberculosis.

Orthologs

Ortholog group members (OG5_237839)

Species Accession Gene Product
Mycobacterium leprae ML2655   SECRETED ANTIGEN 85-C FBPC (85C) (ANTIGEN 85 COMPLEX C) (AG58C) (MYCOLYL TRANSFERASE 85C) (FIBRONECTIN-BINDING PROTEIN C)
Mycobacterium tuberculosis Rv0129c   Secreted antigen 85-C FbpC (85C) (antigen 85 complex C) (AG58C) (mycolyl transferase 85C) (fibronectin-binding protein C)
Mycobacterium ulcerans MUL_4793   secreted antigen 85-C FbpC

Essentiality

Rv0129c has direct evidence of essentiality
Gene/Ortholog Organism Phenotype Source Study
mtu130 this record Mycobacterium tuberculosis non-essential nmpdr
Show/Hide essentiality data references
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.


Annotated validation

No validation data for this target

Associated compounds / Druggability

Druggability index (range: 0 to 1): 0.2


Known modulators for this target

Compound Source Reference
ChEMBL23 References
ChEMBL23 References
ChEMBL23 References
ChEMBL23 References
ChEMBL23 References
ChEMBL23 References
ChEMBL23 References
ChEMBL23 References
Curated by TDRTargets References
ChEMBL23 References
ChEMBL23 References

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets

Obtained from network model

Ranking Plot


Putative Drugs List


Compound Raw Global Species
0.0848 0.49 0.5
0.0924 0.2985 1
0.1174 1 1
0.0851 1 1
0.0883 0.7273 1
0.0829 0.5 0.5
0.0823 1 0.5
0.0883 0.7273 1
0.1894 0.3289 1
0.0935 0.4399 0.5519
0.0737 0.8835 1
0.1823 0.549 1
0.1023 0.5 0.5
0.0823 0.2891 1
0.0823 0.2891 1
0.3606 0.2736 0.715
0.0852 0.7037 1
0.0879 1 1
0.0831 0.3281 0.607
0.1077 0.2717 0.3019
0.1023 1 1
0.0737 0.8835 1
0.0924 0.2985 1
0.0901 0.7583 0.5
0.0697 0.8183 1
0.0831 0.3281 0.607
0.3591 0.9144 1
0.2822 1 1
0.1155 0.5306 1
0.085 0.5118 1
0.0935 0.4399 0.5519
0.1894 0.3289 1
0.0861 0.6239 1
0.0902 0.4994 1
0.1823 0.549 1
0.0902 0.4994 1
0.0643 0.5 0.5
0.0834 0.7818 1
0.1023 1 1
0.149 0.4426 1
0.0898 1 1
0.1699 1 1
0.0861 0.9524 1
0.0823 1 0.5
0.0902 0.4994 1
0.0831 0.8498 1
0.0902 0.4994 1
0.1823 0.549 1
0.13088 0.425836 1
0.0924 0.6088 1
0.0867 0.9813 1
0.0891 0.516 0.5
0.1086 0.3194 0.3191
0.0929 0.5 0.5
0.0902 0.5792 1
0.0826 0.5577 1
0.0861 0.6239 1
0.0839 0.7121 0.5
0.1823 0.549 1
0.118547 0.388891 0.5
0.0823 0.2891 1
0.0848 0.49 0.5
0.0867 0.9813 1
0.075 0.7229 0.5
0.0888 0.7314 1
0.1023 1 1
0.1791 1 1
0.0826 0.5577 1
0.0762 1 1
0.0852 0.7037 1
0.5445 0.3054 1
0.1823 0.549 1
0.1894 0.3289 1
0.1023 0.2802 1
0.1823 0.549 1
0.1023 0.2802 1
0.0825 0.7521 1
0.1894 0.3289 1
0.0788 1 0.5
0.0857 0.5934 1
0.0848 0.8757 1
0.1823 0.549 1
0.0883 0.7273 1
0.0883 0.7273 1
0.1023 0.4102 1
0.1023 0.4102 1
0.0891 0.516 0.5
0.0901 0.7583 0.5
0.0861 0.6239 1
0.0822 0.9266 1
0.1894 0.3289 1
0.1894 0.3289 1
0.0502 0.3224 1
0.0834 0.7818 1
0.1023 0.4102 1
0.083 0.9047 1
0.3606 0.2736 0.715
0.0697 0.8183 1
0.1971 1 1
0.1861 1 1
0.0883 0.7273 1
0.0826 0.5577 1
0.0828 1 1
0.0935 0.4399 0.5519
0.0819 0.7629 1
0.0901 0.7583 0.5
0.0924 0.2985 1
0.1823 0.549 1
0.0879 1 1
0.0935 0.4399 0.5519
0.22 1 1
0.1823 0.549 1
0.1823 0.549 1
0.0737 0.8835 1
0.0724 0.3127 0.3111
0.0929 0.4548 1
0.0851 1 1
0.1023 0.4102 1
0.0924 0.2985 1
0.0826 0.5577 1
0.075 0.7229 0.5
0.0937 0.5 0.5
0.0883 0.7273 1
0.0891 0.6288 0.5
0.1023 0.2802 1
0.0867 0.9813 1
0.1894 0.3289 1
0.1894 0.3289 1
0.1791 1 1
0.0945 0.5031 1
0.0925 0.6071 1
0.0832 0.7418 1
0.0949 0.3789 0.3766
0.0929 0.4548 1
0.0831 0.9299 1
0.4526 0.2703 0.8503
0.1894 0.3289 1
0.0883 0.7273 1
0.0697 0.8183 1
0.0823 0.2891 1
0.085 0.5118 1
0.181 1 1
0.1894 0.3289 1
0.0839 0.7121 0.5
0.0898 1 1
0.0962 1 1
0.083 0.874 1
0.075 0.7229 0.5
0.0945 0.5031 1
0.122028 0.5 0.5
0.0834 0.7818 1
0.0837 0.7544 1
0.0697 0.8183 1
0.4526 0.2703 0.8503
0.0924 0.2985 1
0.1894 0.3289 1
0.0834 0.7818 1
0.0831 0.3281 0.607
0.1959 1 1
0.0841 0.7719 1
0.0823 0.2891 1
0.0891 0.6288 0.5
0.0829 0.7433 1
0.0891 0.516 0.5
0.1823 0.549 1
0.0851 1 1
0.075 0.7229 0.5
0.1823 0.549 1
0.3606 0.2736 0.715
0.0935 0.4399 0.5519
0.1894 0.3289 1
0.0697 0.8183 1
0.0879 0.5 0.5
0.0831 0.3281 0.607
0.0891 0.516 0.5
0.1894 0.3289 1
0.0827 1 0.5
0.3591 0.9144 1

Assayability

Assay information

  • Inhibition of Mycobacterium tuberculosis recombinant antigen 85C mycolyltransferase ChEMBL
  • Inhibition of Mycobacterium tuberculosis recombinant antigen 85C mycolyltransferase
  • In vitro concentration required to inhibit antigen 85C mycolyltransferase activity in Mycobaterium tuberculosis ChEMBL
  • In vitro concentration required to inhibit antigen 85C mycolyltransferase activity in Mycobacterium tuberculosis
  • ChEMBL
  • Inhibition of mycolyltransferase activity of Mycobacterium tuberculosis antigen 85C by UV-visible absorption spectroscopy
  • ChEMBL
  • Inhibition of mycolyltransferase activity of Mycobacterium tuberculosis antigen 85C at 1 to 20 mM by UV-visible absorption spectroscopy
  • ChEMBL
  • Binding affinity to substrate binding site of multidrug resistance Mycobacterium tuberculosis antigen 85C by NMR assay

Reagent availability

  • Reagent:
  • Target Type Source Notes
    Rv0129c cloned gene BRENDA A gene with this EC number or name or sequence has been cloned from Mycobacterium tuberculosis ( 1 )

Bibliographic References

228 literature references were collected for this gene.

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Gene identifier Rv0129c (Mycobacterium tuberculosis), Secreted antigen 85-C FbpC (85C) (antigen 85 complex C) (AG58C) (mycolyl transferase 85C) (fibronectin-binding protein C)
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