pI: 5.5789 |
Length (AA): 1624 |
MW (Da): 176900 |
Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 3 models calculated for this protein. More info on
these models, including the
models themselves is available at:
|Target Beg||Target End||Template||Template Beg||Template End||Identity||Evalue||Model Score||MPQS||zDope|
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
|Lower 0-20% percentile||Dormant phase, Dormant phase.||hasan murphy|
|hasan||Prioritizing genomic drug targets in pathogens: application to Mycobacterium tuberculosis.|
|murphy||Identification of gene targets against dormant phase Mycobacterium tuberculosis infections.|
Ortholog group members (OG5_144539)
|Mycobacterium leprae||ML1249||PROBABLE NAD-DEPENDENT GLUTAMATE DEHYDROGENASE GDH (NAD-GDH) (NAD-DEPENDENT GLUTAMIC DEHYDROGENASE)|
|Mycobacterium tuberculosis||Rv2476c||Probable NAD-dependent glutamate dehydrogenase Gdh (NAD-Gdh) (NAD-dependent glutamic dehydrogenase)|
|Wolbachia endosymbiont of Brugia malayi||Wbm0182||NAD-specific glutamate dehydrogenase|
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.