Detailed view for Rv0411c

Basic information

TDR Targets ID: 6155
Mycobacterium tuberculosis, Probable glutamine-binding lipoprotein GlnH (GLNBP)

Source Database / ID: Tuberculist / Rv0411c 

pI: 5.2097 | Length (AA): 328 | MW (Da): 35406 | Paralog Number: 0

Signal peptide: Y | GPI Anchor: | Predicted trans-membrane segments: 0

Pfam domains

PF00497   Bacterial extracellular solute-binding proteins, family 3

Gene Ontology

Mouse over links to read term descriptions.
GO:0030288   outer membrane-bounded periplasmic space  
GO:0005215   transporter activity  
GO:0006810   transport  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 2 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
26 67 2kpy (A) 53 98 33.00 0.1 0.01 0.314249 0.49
42 328 6h20 (A) 42 328 99.99 0 1 2.132 -1.66

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:


Upregulation Percent Ranking Shows this level of upregulation in
This gene ranks in the upper 60-80% group of genes. Dormant phase.
Upregulation Percent Ranking Shows this level of upregulation in
This gene ranks in the mid 40-60% group of genes. Dormant phase.
Show/Hide expression data references
  • hasan Prioritizing genomic drug targets in pathogens: application to Mycobacterium tuberculosis.
  • murphy Identification of gene targets against dormant phase Mycobacterium tuberculosis infections.


Ortholog group members (OG5_127777)

Species Accession Gene Product
Chlamydia trachomatis CT_486   glutamine binding protein
Chlamydia trachomatis CT_381   arginine ABC transporter substrate-binding protein ArtJ
Escherichia coli b0860   arginine binding protein, periplasmic
Escherichia coli b1920   cystine transporter subunit
Escherichia coli b0811   glutamine transporter subunit
Mycobacterium leprae ML0303   Probable glutamine-binding protein GlnH (GLNBP)
Mycobacterium tuberculosis Rv0411c this record   Probable glutamine-binding lipoprotein GlnH (GLNBP)
Mycobacterium ulcerans MUL_2809   glutamine-binding lipoprotein GlnH
Treponema pallidum TP0309   amino acid ABC transporter, periplasmic binding protein
Treponema pallidum TP0308   amino acid ABC transporter, periplasmic binding protein (hisJ)


Rv0411c has direct evidence of essentiality
Gene/Ortholog Organism Phenotype Source Study
mtu414 this record Mycobacterium tuberculosis essential nmpdr
b0811 Escherichia coli non-essential goodall
b0860 Escherichia coli non-essential goodall
b1920 Escherichia coli non-essential goodall
Show/Hide essentiality data references
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • wormbase C. elegans RNAi experiments WormBase web site,, release WS170
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets

Obtained from network model

Ranking Plot

Putative Drugs List

Compound Raw Global Species
0.0433 0.6196 0.5
0.048 0.6664 1
0.0427 0.2919 0.8485
0.0069 0.5869 0.5
0.0052 0.6099 1
0.0361 0.4787 0.8304
0.0178 0.6959 1
0.1077 0.7165 0.5
0.0318 0.5685 1
0.0022 0.2604 0
0.0145 0.3122 1
0.1604 0.7174 1
0.0184 0.2805 0.9104
0.0398 0.4386 0.5
0.0092 0.6726 0.5
0.0381 0.4087 1
0.0065 0.6183 1
0.0397 0.2804 1
0.0691 0.3985 1
0.0144 0.6722 0.5


Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

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User comments

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Gene identifier Rv0411c (Mycobacterium tuberculosis), Probable glutamine-binding lipoprotein GlnH (GLNBP)
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