pI: 5.4602 |
Length (AA): 368 |
MW (Da): 39666 |
Paralog Number:
0
Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There is 1 model calculated for this protein. More info on
this model, including the
model itself is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
6 | 368 | 3dtg (A) | 6 | 368 | 85.00 | 0 | 1 | 2.01501 | -0.94 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Resolution | Method | # Atoms | # Residues | Dep. Date | Pub. Date | Mod. Date |
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Resolution | Method | # Atoms | # Residues | Dep. Date | Pub. Date | Mod. Date |
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Resolution | Method | # Atoms | # Residues | Dep. Date | Pub. Date | Mod. Date |
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Resolution | Method | # Atoms | # Residues | Dep. Date | Pub. Date | Mod. Date |
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Resolution | Method | # Atoms | # Residues | Dep. Date | Pub. Date | Mod. Date |
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Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Upper 60-80% percentile | Dormant phase. | hasan |
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Lower 0-20% percentile | Dormant phase. | murphy |
murphy | Identification of gene targets against dormant phase Mycobacterium tuberculosis infections. |
hasan | Prioritizing genomic drug targets in pathogens: application to Mycobacterium tuberculosis. |
Ortholog group members (OG5_126731)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT3G05190 | branched-chain-amino-acid aminotransferase-like protein 1 |
Arabidopsis thaliana | AT5G27410 | branched-chain-amino-acid aminotransferase-like protein 2 |
Arabidopsis thaliana | AT1G10070 | branched-chain-amino-acid aminotransferase 2 |
Arabidopsis thaliana | AT3G49680 | branched-chain-amino-acid aminotransferase 3 |
Brugia malayi | Bm1_37270 | Branched-chain amino acid aminotransferase, cytosolic, putative |
Candida albicans | CaO19.8417 | N terminus of likely Branched-chain Amino acid Transaminase CaP19.797 |
Candida albicans | CaO19.8416 | N terminus of likely Branched-chain Amino acid Transaminase CaP19.797 |
Candida albicans | CaO19.797 | similar to S. cerevisiae branched-chain amino acid transaminase BAT2 (YJR148W) expressed during stationary phase |
Candida albicans | CaO19.6994 | Branched-chain amino acid transaminase |
Caenorhabditis elegans | CELE_K02A4.1 | Protein BCAT-1 |
Caenorhabditis elegans | CELE_Y44A6D.5 | Protein Y44A6D.5 |
Dictyostelium discoideum | DDB_G0285509 | branched-chain amino acid aminotransferase |
Drosophila melanogaster | Dmel_CG1673 | CG1673 gene product from transcript CG1673-RA |
Escherichia coli | b3770 | branched-chain amino-acid aminotransferase |
Entamoeba histolytica | EHI_152310 | branched-chain amino acid aminotransferase, putative |
Giardia lamblia | GL50803_6184 | Branched-chain amino acid aminotransferase lateral transfer candidate |
Homo sapiens | ENSG00000105552 | branched chain amino-acid transaminase 2, mitochondrial |
Homo sapiens | ENSG00000060982 | branched chain amino-acid transaminase 1, cytosolic |
Leishmania braziliensis | LbrM.27.2210 | branched-chain amino acid aminotransferase, putative |
Leishmania infantum | LinJ.27.1950 | branched-chain amino acid aminotransferase, putative |
Leishmania major | LmjF.27.2030 | branched-chain amino acid aminotransferase, putative |
Leishmania mexicana | LmxM.27.2032 | branched-chain amino acid aminotransferase, putative |
Leishmania mexicana | LmxM.27.2030 | branched-chain amino acid aminotransferase, putative |
Loa Loa (eye worm) | LOAG_04874 | branched-chain amino acid aminotransferase |
Mycobacterium leprae | ML0866 | PROBABLE BRANCHED-CHAIN AMINO ACID TRANSAMINASE ILVE |
Mus musculus | ENSMUSG00000030268 | branched chain aminotransferase 1, cytosolic |
Mus musculus | ENSMUSG00000030826 | branched chain aminotransferase 2, mitochondrial |
Mycobacterium tuberculosis | Rv2210c | Branched-chain amino acid transaminase IlvE |
Mycobacterium ulcerans | MUL_3570 | branched-chain amino acid aminotransferase |
Neospora caninum | NCLIV_006760 | Branched-chain-amino-acid aminotransferase (EC 2.6.1.42), related |
Oryza sativa | 4331322 | Os03g0106400 |
Oryza sativa | 9270815 | Os03g0359100 |
Oryza sativa | 4339583 | Os05g0558400 |
Oryza sativa | 4332151 | Os03g0231600 |
Oryza sativa | 4336645 | Os04g0559400 |
Saccharomyces cerevisiae | YJR148W | branched-chain-amino-acid transaminase BAT2 |
Saccharomyces cerevisiae | YHR208W | branched-chain-amino-acid transaminase BAT1 |
Schmidtea mediterranea | mk4.027344.01 | Branched-chain-amino-acid aminotransferase |
Schmidtea mediterranea | mk4.001344.04 | Branched-chain-amino-acid aminotransferase, cytosolic |
Trypanosoma brucei gambiense | Tbg.972.2.2670 | branched-chain amino acid aminotransferase, putative |
Trypanosoma brucei gambiense | Tbg.972.2.2660 | branched-chain amino acid aminotransferase, putative |
Trypanosoma brucei | Tb927.2.4590 | branched-chain amino acid aminotransferase, putative |
Trypanosoma brucei | Tb927.2.4610 | branched-chain amino acid aminotransferase, putative |
Trypanosoma brucei | Tb11.v5.0820 | branched-chain amino acid aminotransferase, putative |
Trypanosoma congolense | TcIL3000_0_53430 | branched-chain amino acid aminotransferase, putative |
Toxoplasma gondii | TGME49_297850 | Branched-chain-amino-acid aminotransferase |
Trichomonas vaginalis | TVAG_026740 | branched-chain amino acid aminotransferase, putative |
Trichomonas vaginalis | TVAG_139240 | subgroup IIIi aminotransferase, putative |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
mtu2244 this record | Mycobacterium tuberculosis | essential | nmpdr |
Tb927.2.4590 | Trypanosoma brucei | significant gain of fitness in bloodstream forms (3 days) | alsford |
Tb927.2.4590 | Trypanosoma brucei | significant gain of fitness in bloodstream forms (6 days) | alsford |
Tb927.2.4590 | Trypanosoma brucei | no significant loss or gain of fitness in procyclic forms | alsford |
Tb927.2.4590 | Trypanosoma brucei | significant gain of fitness in differentiation of procyclic to bloodstream forms | alsford |
b3770 | Escherichia coli | non-essential | goodall |
CELE_K02A4.1 | Caenorhabditis elegans | embryonic lethal | wormbase |
CELE_K02A4.1 | Caenorhabditis elegans | larval lethal | wormbase |
TGME49_297850 | Toxoplasma gondii | Probably non-essential | sidik |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
Species | Known druggable target | Linked compounds | Reference |
---|---|---|---|
Rattus norvegicus | Branched-chain-amino-acid transferase | Compounds | References |
Homo sapiens | branched chain amino-acid transaminase 2, mitochondrial | Compounds | References |
Rattus norvegicus | Branched-chain-amino-acid transferase | Compounds | References |
Homo sapiens | branched chain amino-acid transaminase 1, cytosolic | Compounds | References |
Target | Type | Source | Notes |
---|---|---|---|
Rv2210c | cloned gene | BRENDA | A gene with this EC number or name or sequence has been cloned from Mycobacterium tuberculosis ( 1 ) |
1 literature reference was collected for this gene.