Detailed view for Rv2384

Basic information

TDR Targets ID: 6410
Mycobacterium tuberculosis, Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase

Source Database / ID:  Tuberculist 

pI: 5.9139 | Length (AA): 565 | MW (Da): 59281 | Paralog Number: 0

Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00501   AMP-binding enzyme
PF13193   AMP-binding enzyme C-terminal domain

Gene Ontology

Mouse over links to read term descriptions.
GO:0003824   catalytic activity  
GO:0008152   metabolic process  

Structural information

Modbase 3D models:

There are 2 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
13 552 5kei (A) 18 556 71.00 0 1 1.80655 -0.88
20 453 3o83 (A) 8 437 39.00 0 1 1.31824 -0.91

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

Upregulation Percent Ranking Stage Dataset
Upper 80-100% percentile Dormant phase. murphy
Upregulation Percent Ranking Stage Dataset
Mid 40-60% percentile Dormant phase. hasan
Show/Hide expression data references
  • hasan Prioritizing genomic drug targets in pathogens: application to Mycobacterium tuberculosis.
  • murphy Identification of gene targets against dormant phase Mycobacterium tuberculosis infections.

Orthologs

Ortholog group members (OG5_146698)

Species Accession Gene Product
Escherichia coli b0594   2,3-dihydroxybenzoate-AMP ligase component of enterobactin synthase multienzyme complex
Mycobacterium tuberculosis Rv2384   Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase
Mycobacterium ulcerans MUL_3641   bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ACP synthetase

Essentiality

Rv2384 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
b0594 Escherichia coli non-essential goodall
Show/Hide essentiality data references
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.


Annotated validation

No validation data for this target

Associated compounds / Druggability

Druggability index (range: 0 to 1): 0.2


Known modulators for this target

91 chemical compounds are associated with this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Escherichia coli 2,3-dihydroxybenzoate-AMP ligase component of enterobactin synthase multienzyme complex Compounds References
Yersinia pestis AMP-binding enzyme family protein Compounds References
By sequence similarity to non orthologous druggable targets
Species Target Length Identity Alignment span Linked Drugs Reference
Photuris pennsylvanica Luciferase 552 aa 22.3% 503 aa Compounds References
Photinus pyralis Luciferin 4-monooxygenase 550 aa 24.4% 536 aa Compounds References
Photuris pennsylvanica Luciferin 4-monooxygenase 545 aa 24.0% 505 aa Compounds References
Luciola lateralis Luciferase 548 aa 24.9% 498 aa Compounds References

Obtained from network model

Ranking Plot


Putative Drugs List


Compound Raw Global Species
1.3529 0.5414 1
0.0328 0.5335 1
0.0675 0.7567 1
0.0675 0.3031 0.5
0.2608 0.2899 1
0.069 0.3233 0.7162
0.0675 0.7765 1
0.5832 0.845 0.5
0.4511 0.3494 1
0.2963 0.4781 0.9676
0.6408 0.3926 0.793
0.1287 0.9082 1
0.0284 0.5308 0.9221
0.04 0.5101 0.5
0.0543 0.2872 0.3093
1.48642 0.332823 1
2.1535 0.2886 1
0.2963 0.4781 0.9676
2.1535 0.2886 1
2.1535 0.2886 1
0.6408 0.3926 0.793
0.0308 0.3009 0.948
0.0704 0.3227 1
2.1535 0.2886 1
2.1535 0.2886 1
0.2963 0.4781 0.9676
0.2963 0.4781 0.9676
0.4511 0.3494 1
0.0401 0.5339 0.5
2.1535 0.2886 1
0.4511 0.3494 1
0.1522 0.996 1
2.1535 0.2886 1
1.3529 0.5414 1
2.1535 0.2886 1
0.0675 0.5051 1
0.143 0.5125 0.6383
2.1535 0.292 1
1.0255 0.3111 0.6347
2.1535 0.2886 1
0.1856 0.6161 1
0.062 0.9405 1
0.2963 0.4781 0.9676
0.6408 0.3926 0.793
0.137593 0.691152 1
2.1535 0.2886 1
2.1535 0.2886 1
1.2728 0.5875 1
0.0675 0.78 1
1.3529 0.5414 1
0.6408 0.3926 0.793
0.0548 0.3076 1
0.6408 0.3926 0.793
2.1535 0.2886 1
0.114 0.3775 1
2.019 0.8936 1
0.114 0.3775 1
2.1528 0.2916 1
2.1535 0.2886 1
0.6408 0.3926 0.793
0.2963 0.4781 0.9676
1.2728 0.5875 1
0.0682 0.5823 1
0.0675 0.3236 1
0.0335 0.4507 1
1.3529 0.5414 1
0.1306 0.2936 1
0.0675 0.9385 1
1.2728 0.5875 1
0.069 0.3233 0.7162
2.1535 0.2886 1
1.3529 0.5414 1
0.114 0.3775 1
2.1535 0.2886 1
2.1535 0.2886 1
0.1513 0.2799 0.7398
0.137593 0.691152 1
2.1535 0.2886 1
0.0683 0.3196 1
2.1277 0.8936 1
0.183 0.3194 1
2.1535 0.2886 1
0.0775 0.9237 1
2.1535 0.2886 1
0.0675 0.9378 1
0.0276 0.346 1
0.0553 0.2685 0.4862
0.0689 0.4283 1
0.6408 0.3926 0.793
2.1535 0.2886 1
0.0021 0.2636 0.2636
0.2963 0.4781 0.9676
0.1204 0.3133 1
0.393 0.2844 1
0.1287 0.9082 1
0.0548 0.3076 1
1.3529 0.5414 1
0.2963 0.4781 0.9676
0.0675 0.8511 1
1.8922 0.8936 1
0.0343 0.3449 1
0.6408 0.3926 0.793
1.0323 0.5972 1
0.0682 0.832 1
1.3529 0.5414 1
2.1535 0.2886 1
0.114 0.3775 1
0.0557 0.2693 0.3305
1.3529 0.5414 1
0.0682 0.3874 1
2.1535 0.2886 1
0.5012 0.405 1
0.6408 0.3926 0.793
0.0689 0.8239 1
0.0691 0.8974 1
0.2963 0.4781 0.9676
0.6408 0.3926 0.793
1.3529 0.5414 1
0.0193 0.2636 0.2636
0.4778 0.6108 1
1.8812 0.8887 1
0.0311 0.3753 1
2.1535 0.2886 1
1.2728 0.5875 1
0.0543 0.8846 0.8842
0.0548 0.3076 1
0.0675 0.7571 1
2.1535 0.2886 1
0.4511 0.3494 1
0.0523 0.6632 1
0.0553 0.3205 1
0.0557 0.2693 0.3305
1.3231 0.4074 1
0.3169 0.2537 0.5
2.1535 0.2886 1
0.1282 0.7988 1
0.5034 0.3976 1
2.019 0.8936 1
0.1287 0.9082 1
1.3529 0.5414 1
0.0696 0.5589 1
0.0675 0.3043 1
0.5034 0.3976 1
0.2963 0.4781 0.9676
2.1535 0.2886 1
0.0675 0.9429 1
1.3529 0.5414 1
1.3529 0.5414 1
2.1535 0.2886 1
0.2963 0.4781 0.9676
2.1535 0.2886 1
1.3529 0.5414 1
2.1535 0.2886 1
2.1277 0.8936 1
0.0193 0.2636 0.2636
0.0572 0.4548 0.479
0.0682 0.832 1
1.2728 0.5875 1
2.1535 0.2886 1
2.1535 0.2886 1
1.2728 0.5875 1
2.1535 0.2886 1
0.0504 0.3252 0.3511
2.1535 0.2886 1
2.1535 0.2886 1
2.1535 0.2886 1
0.1762 0.5328 0.5328
0.2963 0.4781 0.9676
1.3529 0.5414 1
0.0675 0.3858 0.4098
0.2303 0.4376 1
0.0573 0.4154 0.7281
0.0571 0.6652 0.5
0.0542 0.6472 1
2.1535 0.2886 1
1.3529 0.5414 1
0.2462 0.4273 1
0.6408 0.3926 0.793
2.1535 0.2886 1
0.5034 0.3976 1
2.1535 0.2886 1
0.3057 0.2822 1
0.3422 0.3644 1
0.6408 0.3926 0.793
0.0675 0.9385 1
0.2963 0.4781 0.9676
0.0675 0.7978 0.5
0.063 0.574 0.7056
2.1535 0.2886 1
0.0675 0.7571 1
0.2473 0.3044 0.3305
2.1535 0.2886 1
0.0675 0.3866 1
2.1535 0.2886 1
0.0682 0.3874 1
0.5034 0.3976 1
0.1287 0.9082 1
0.3305 0.668 0.7501
0.6408 0.3926 0.793
0.5034 0.3976 1
0.0088 0.2627 0.0546
1.8915 0.9488 1
0.8821 0.3278 0.7106
0.0683 0.5667 1
2.1535 0.2886 1
0.4511 0.3494 1
0.5034 0.3976 1
1.3529 0.5414 1
0.0675 0.2545 1
0.137593 0.691152 1
0.1144 0.4471 0.4468
0.0541 0.2737 1
2.1535 0.2886 1
0.0617 0.9405 1
0.4778 0.6108 1
2.1535 0.2886 1
0.1306 0.2936 1
0.252331 1 1
0.2855 0.6218 0.6687
0.062 0.5849 1
0.2303 0.4376 1
2.1535 0.2886 1
2.1535 0.2886 1
0.0682 0.3244 1
2.1535 0.2886 1
2.1535 0.2886 1
0.183 0.3195 1
0.1287 0.9082 1
2.1535 0.2886 1
2.1535 0.2886 1
2.1535 0.2886 1
1.3529 0.5414 1
0.1634 0.7816 0.8404
2.1535 0.2886 1
0.1709 0.6613 0.6613
0.6408 0.3926 0.793
0.4511 0.3494 1
0.6408 0.3926 0.793
0.0775 0.9237 1
0.0682 0.43 1
0.3033 0.2943 1
0.2963 0.4781 0.9676
0.0417 0.2567 1
2.1535 0.2886 1
2.1535 0.2886 1
2.1535 0.2886 1
0.775 0.8662 1
0.724537 1 1
2.1535 0.2886 1
0.2963 0.4781 0.9676
0.3305 0.668 0.7501
0.3033 0.2943 1
1.0233 0.5682 1
0.4778 0.6108 1
0.4511 0.3494 1
2.1535 0.2886 1
0.0675 0.3823 1
0.0675 0.7765 1
1.3529 0.5414 1
0.0675 0.3031 0.5
0.0675 0.3138 1
0.2963 0.4781 0.9676
0.5034 0.3976 1
0.2963 0.4781 0.9676
0.1448 0.8019 1
0.2963 0.4781 0.9676
0.1718 0.5342 0.5342
1.3529 0.5414 1
0.055 0.2531 1
1.3529 0.5414 1
2.1535 0.2886 1
0.0689 0.8239 1
0.1968 0.8463 1
0.055 0.2531 1
1.2728 0.5875 1
2.1535 0.2886 1
0.5034 0.3976 1
0.1154 0.2551 1
2.1535 0.2886 1
2.1535 0.2886 1
0.0675 0.9429 1
0.0566 0.5744 0.6045
1.0233 0.5682 1
0.0367 0.8662 1
2.1535 0.2886 1
0.1763 0.7627 1
0.0682 0.8415 1
2.1535 0.2886 1
0.0541 0.2875 1
2.1535 0.2886 1
1.7705 0.9425 1
0.0675 0.5051 1
0.1513 0.2799 0.7398
2.1535 0.2886 1
2.0098 0.8887 1
0.0548 0.3076 1
0.3305 0.668 0.7501
0.0675 0.4856 1
0.1043 0.3204 1
2.04089 0.972143 1
0.4511 0.3494 1
2.1535 0.2886 1
0.0689 0.4971 1
1.4322 0.3072 1
2.1535 0.2886 1
0.0675 0.7166 1
0.2963 0.4781 0.9676
0.0553 0.2612 1
0.1283 0.9623 0.5
0.0675 0.3118 1
2.1535 0.2886 1
0.0683 0.5667 1
0.6408 0.3926 0.793
0.114 0.3775 1
2.1165 0.9363 1
0.0612 0.7494 1
0.0417 0.2567 1
2.1535 0.2886 1
2.1535 0.2886 1
0.4511 0.3494 1
0.2963 0.4781 0.9676
1.3529 0.5414 1
0.0675 0.6587 0.6587
0.6408 0.3926 0.793
0.0343 0.3449 1
0.5034 0.3976 1
1.0614 0.6177 1
0.0675 0.8041 1
0.114 0.3775 1
0.2963 0.4781 0.9676
0.1706 0.6809 0.6805
1.8812 0.8887 1
2.1535 0.2886 1
1.2728 0.5875 1
0.116 0.7631 0.8213
0.3228 0.3086 1
2.1535 0.2886 1
0.0573 0.7282 0.7281
0.0557 0.3156 1
2.1535 0.2886 1
0.0557 0.6649 1
0.1114 0.5045 1
0.0555 0.3587 1
0.0675 0.2776 1
0.0675 0.3302 0.3406
2.1535 0.2886 1
0.2853 0.4581 1
0.7074 0.3331 0.9274
2.41891 1 1
0.0682 0.7975 1
1.832 0.3819 1
0.0682 0.9818 1
0.0345 0.5335 1
2.1535 0.2886 1
0.775 0.8662 1
0.0548 0.3076 1
2.1535 0.2886 1
0.0648 0.4495 1
0.0675 0.9335 1
0.0675 0.3171 0.3889
1.3529 0.5414 1
2.1535 0.2886 1
0.0636 0.6552 0.7052
2.1344 0.9363 1
2.1535 0.2886 1
0.0569 0.2647 0.2776
1.3529 0.5414 1
2.1535 0.2886 1
0.0675 0.2701 0.9183
0.2853 0.4581 1
0.0683 0.3196 1
0.374 0.2692 1
0.4511 0.3494 1
0.6408 0.3926 0.793
0.0455 0.2753 0.2958
2.1535 0.2886 1
2.1535 0.2886 1
0.4511 0.3494 1
0.3305 0.668 0.7501
0.6408 0.3926 0.793
0.2963 0.4781 0.9676
1.7705 0.9425 1
0.0675 0.4856 1
0.1448 0.8019 1
0.1497 0.3472 1
0.114 0.3775 1
0.9429 0.4946 1
2.1535 0.2886 1
2.1535 0.2886 1
0.1139 0.4404 0.4404
2.1535 0.2886 1
0.1567 0.6921 1
2.1535 0.2886 1
2.1535 0.2886 1
2.1535 0.2886 1
1.1672 0.5664 1
2.1535 0.2886 1
0.087 0.9313 1
0.1703 0.2776 1
2.1535 0.2886 1
2.1535 0.2886 1
0.3305 0.668 0.7501
0.1282 0.7988 1
0.114 0.3775 1
0.1103 0.535 1
0.5034 0.3976 1
1.0233 0.5682 1
0.0276 0.346 1
0.2963 0.4781 0.9676
0.7041 0.5898 1
0.0862 0.9449 1
0.0675 0.8523 1
0.0675 0.7147 1
0.2963 0.4781 0.9676
1.2728 0.5875 1
1.3529 0.5414 1
0.036 0.3753 1
2.1535 0.2886 1
0.4511 0.3494 1
0.0602 0.9403 1
0.046 0.8498 1
2.1535 0.2886 1
0.1043 0.3204 1
0.3057 0.2822 1
0.1497 0.3472 1
0.7819 0.3927 0.9441
2.1535 0.2886 1
1.0359 0.9474 1
0.0675 0.8853 1
0.5034 0.3976 1
0.0614 0.9405 1
0.1282 0.7988 1
0.0682 0.5823 1
0.0675 0.7567 1
0.8821 0.3278 0.7106
0.1634 0.7816 0.8404
0.0683 0.7607 1
0.4511 0.3494 1
0.0556 0.6302 1
1.2728 0.5875 1
0.0541 0.2737 1
1.3231 0.4074 1
1.2728 0.5875 1
0.0704 0.3227 1
2.1535 0.2886 1
1.7705 0.9425 1
1.7705 0.9425 1
0.0317 0.353 0.3512
0.5034 0.3976 1
0.0566 0.5744 0.6045
2.1535 0.2886 1
0.2963 0.4781 0.9676
2.1535 0.2886 1
2.1535 0.2886 1
2.1535 0.2886 1
0.057 0.3115 0.3114
0.0675 0.3236 1
0.0675 0.3118 1
0.6408 0.3926 0.793
0.0523 0.3161 0.2895
0.0551 0.4023 0.4011
0.2716 0.3229 1
2.1535 0.2886 1
2.1535 0.2886 1
2.1535 0.2886 1
1.3529 0.5414 1
1.2728 0.5875 1
2.1535 0.2886 1
2.1535 0.2886 1
1.025 0.3193 0.6344
0.1204 0.3133 1
0.6408 0.3926 0.793
2.1535 0.2886 1
1.2728 0.5875 1
2.1535 0.2886 1
2.1535 0.2886 1
2.1535 0.2886 1
0.0543 0.6088 0.6553
0.0675 0.3823 1
0.0704 0.3227 1
2.1535 0.2886 1
0.0675 0.3908 0.5
1.2728 0.5875 1
0.0648 0.4495 1
0.26 0.3566 1
0.0989 0.5842 0.5
0.0542 0.5906 0.5
2.1535 0.2886 1
0.2963 0.4781 0.9676
0.3521 0.8235 1
0.2963 0.4781 0.9676
0.0439 0.468 1
0.6812 0.3456 0.5969
0.6408 0.3926 0.793
2.1535 0.2886 1
0.4511 0.3494 1
2.1535 0.2886 1
2.1535 0.2886 1
2.1535 0.2886 1
1.3529 0.5414 1
1.2728 0.5875 1
0.183 0.3195 1
0.4511 0.3494 1
2.1535 0.2886 1
0.775 0.8662 1
0.1154 0.2551 1
0.0675 0.3858 0.4098
2.2416 0.9363 1
2.1535 0.2886 1
0.4511 0.3494 1
0.1913 0.9459 1
0.3305 0.668 0.7501
0.2963 0.4781 0.9676
0.1204 0.3133 1
0.2963 0.4781 0.9676
1.3529 0.5414 1
0.6408 0.3926 0.793
0.0675 0.6068 1
0.5561 0.9822 0.5
0.0775 0.9237 1
0.0675 0.3866 1
0.1762 0.5328 0.5328
2.0008 0.8936 1
2.1535 0.2886 1
1.0233 0.5682 1
0.0282 0.5308 0.9221
2.1535 0.2886 1
1.3529 0.5414 1
2.1535 0.2886 1
2.1535 0.2886 1
0.2853 0.4581 1
0.0361 0.5336 1
0.5034 0.3976 1
1.2728 0.5875 1
0.0552 0.2959 0.2959
1.7166 0.4378 0.9124
2.0098 0.8887 1
1.9178 0.8887 1
0.0367 0.5512 1
0.5012 0.405 1
0.6408 0.3926 0.793
1.48642 0.332823 1
0.0276 0.346 1
2.1535 0.2886 1
1.2728 0.5875 1
2.1535 0.2886 1
0.0682 0.43 1
2.1535 0.2886 1
2.1535 0.2886 1
0.062 0.5849 1
0.3305 0.668 0.7501
0.2963 0.4781 0.9676
2.1535 0.2886 1
0.0572 0.4548 0.479
1.7166 0.4378 0.9124
0.6408 0.3926 0.793
2.1535 0.2886 1
0.1203 0.3393 1
0.3422 0.3297 1
2.1535 0.2886 1
2.1535 0.2886 1
0.0675 0.4687 0.6841
0.3057 0.2822 1
0.0675 0.7147 1
2.1535 0.2886 1
1.41675 1 0.5
2.1535 0.2886 1
0.0401 0.5339 0.5
2.1535 0.2886 1
0.0675 0.934 0.5
1.3529 0.5414 1
2.1535 0.2886 1
0.6408 0.3926 0.793
0.5034 0.3976 1
0.0675 0.78 1
0.252331 1 1
2.34343 1 1
0.4511 0.3494 1
0.0612 0.7494 1
2.0183 0.9488 1
0.0675 0.512 1
0.6408 0.3926 0.793
0.6408 0.3926 0.793
0.4778 0.6108 1
0.0682 0.3244 1
0.1287 0.9082 1
0.0675 0.7141 1
2.1535 0.2886 1
1.7705 0.9425 1
1.2728 0.5875 1
0.0411 0.752 0.752
0.3008 0.4555 1
0.1689 0.2636 0.5
2.1535 0.2886 1
0.2232 0.6157 0.6625
0.0689 0.4971 1
0.2963 0.4781 0.9676
2.1535 0.2886 1
0.5034 0.3976 1
1.8915 0.9488 1
1.2728 0.5875 1
2.1535 0.2886 1
0.4511 0.3494 1
0.0775 0.9237 1
0.0571 0.5762 0.5949
0.0345 0.5335 1
0.04 0.5101 0.5
0.1674 0.6776 0.6772
1.3529 0.5414 1
2.1535 0.2886 1
2.2416 0.9363 1
1.0233 0.5682 1
0.6408 0.3926 0.793
0.143 0.5125 0.6383
0.1762 0.662 0.6613
2.1535 0.2886 1
0.1763 0.7627 1
0.6408 0.3926 0.793
0.1104 0.709 1
0.0328 0.5335 1
2.1535 0.2886 1
1.9178 0.8887 1

Assayability

Assay information

  • Inhibition of Mycobacterium tuberculosis MbtA by [32P]PPi-ATP exchange assay ChEMBL
  • Inhibition of Mycobacterium tuberculosis MbtA by [32P]PPi-ATP exchange assay
  • Inhibition of Mycobacterium tuberculosis recombinant MbtA expressed in Escherichia coli by ATP/PPi exchange assay ChEMBL
  • Inhibition of Mycobacterium tuberculosis recombinant MbtA expressed in Escherichia coli by ATP/PPi exchange assay
  • ChEMBL
  • Inhibition of adenylation activity of Mycobacterium tuberculosis MbtA after 30 mins by ATP-[32P]pyrophosphate exchange assay
  • ChEMBL
  • Inhibition of Mycobacterium tuberculosis recombinant MbtA expressed in Escherichia coli by ATP-PPi exchange assay
  • ChEMBL
  • Binding affinity to Mycobacterium tuberculosis recombinant MbtA using saturated levels of salicylic acid substrate by isothermal calorimetry
  • ChEMBL
  • Inhibition of Mycobacterium tuberculosis BAG RV143 MbtA expressed in Escherichia coli BL21 (DE3) assessed as ATP-[32P]PPi exchange by liquid scintillation counting
  • ChEMBL
  • Inhibition of Mycobacterium tuberculosis MbtA expressed in Escherichia coli assessed as ATP-[32P]Ppi exchange

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

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Gene identifier Rv2384 (Mycobacterium tuberculosis), Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase
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