pI: 8.5092 |
Length (AA): 545 |
MW (Da): 59350 |
Paralog Number:
2
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 3 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
78 | 463 | 5xzw (A) | 39 | 465 | 23.00 | 0 | 1 | 0.755957 | 0.56 |
113 | 522 | 3pfq (A) | 194 | 650 | 26.00 | 0 | 1 | 0.910894 | 0.57 |
175 | 482 | 3eqc (A) | 39 | 379 | 43.00 | 0 | 1 | 1.09574 | -0.85 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Ortholog group members (OG5_127304)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT5G56580 | mitogen-activated protein kinase kinase 6 |
Arabidopsis thaliana | AT4G26070 | mitogen-activated protein kinase kinase 1 |
Arabidopsis thaliana | AT4G29810 | mitogen-activated protein kinase kinase 2 |
Brugia malayi | Bm1_48560 | Dual specificity mitogen-activated protein kinase kinase mek-2 |
Candida albicans | CaO19.8100 | likely MAP kinase kinase that can functionally substitute for S. cerevisiae STE7 (YDL159W) |
Candida albicans | CaO19.7388 | member of the HOG1 MAPK cascade |
Candida albicans | CaO19.469 | likely MAP kinase kinase that can functionally substitute for S. cerevisiae STE7 (YDL159W) |
Caenorhabditis elegans | CELE_Y54E10BL.6 | Protein MEK-2 |
Cryptosporidium hominis | Chro.80584 | protein kinase NPK2 (EC 2.7.1.-) |
Cryptosporidium parvum | cgd8_5120 | protein kinase NPK2 |
Dictyostelium discoideum | DDB_G0269152 | MAP kinase kinase |
Drosophila melanogaster | Dmel_CG15793 | Downstream of raf1 |
Echinococcus granulosus | EgrG_000514400 | dual specificity mitogen activated protein |
Echinococcus multilocularis | EmuJ_000514400 | dual specificity mitogen activated protein |
Giardia lamblia | GL50803_22165 | Kinase, STE STE20 |
Homo sapiens | 5604 | mitogen-activated protein kinase kinase 1 |
Homo sapiens | ENSG00000126934 | mitogen-activated protein kinase kinase 2 |
Leishmania braziliensis | LbrM.35.0980 | mitogen-activated protein kinase kinase 5, putative;with=GeneDB:LmxM36.0860 |
Leishmania donovani | LdBPK_360920.1 | mitogen-activated protein kinase kinase 5 |
Leishmania infantum | LinJ.36.0920 | mitogen-activated protein kinase kinase 5, putative;with=GeneDB:LmxM36.0860 |
Leishmania major | LmjF.36.0860 | mitogen-activated protein kinase kinase 5, putative;with=GeneDB:LmxM36.0860 |
Leishmania mexicana | LmxM.36.0860 | protein kinase, putative,mitogen activated protein kinase, putative |
Loa Loa (eye worm) | LOAG_12861 | STE/STE7/MEK1 protein kinase |
Mus musculus | ENSMUSG00000035027 | mitogen-activated protein kinase kinase 2 |
Mus musculus | ENSMUSG00000004936 | mitogen-activated protein kinase kinase 1 |
Oryza sativa | 4340126 | Os06g0147800 |
Oryza sativa | 4324023 | Os01g0510100 |
Saccharomyces cerevisiae | YJL128C | Pbs2p |
Saccharomyces cerevisiae | YDL159W | Ste7p |
Schistosoma japonicum | Sjp_0095630 | Dual specificity mitogen-activated protein kinase kinase 2, putative |
Schistosoma japonicum | Sjp_0027360 | Dual specificity mitogen-activated protein kinase kinase 1, putative |
Schistosoma mansoni | Smp_026510 | protein kinase |
Schmidtea mediterranea | mk4.014624.02 | |
Schmidtea mediterranea | mk4.025092.00 | |
Schmidtea mediterranea | mk4.012524.00 | |
Schmidtea mediterranea | mk4.003933.01 | |
Schmidtea mediterranea | mk4.082302.00 | |
Schmidtea mediterranea | mk4.002789.03 | Dual specificity mitogen-activated protein kinase kinase mek-2 |
Trypanosoma brucei gambiense | Tbg972.10.6430 | protein kinase, putative,MAP kinase kinase, putative |
Trypanosoma brucei | Tb927.10.5270 | mitogen-activated protein kinase kinase 5 |
Trypanosoma congolense | TcIL3000_10_4410 | mitogen-activated protein kinase kinase 5 |
Trypanosoma cruzi | TcCLB.506679.40 | mitogen-activated protein kinase kinase 5 |
Trichomonas vaginalis | TVAG_468570 | STE family protein kinase |
Trichomonas vaginalis | TVAG_495060 | STE family protein kinase |
Trichomonas vaginalis | TVAG_349370 | STE family protein kinase |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
Tb927.10.5270 | Trypanosoma brucei | no significant loss or gain of fitness in bloodstream forms (3 days) | alsford |
Tb927.10.5270 | Trypanosoma brucei | no significant loss or gain of fitness in bloodstream forms (6 days) | alsford |
Tb927.10.5270 | Trypanosoma brucei | no significant loss or gain of fitness in procyclic forms | alsford |
Tb927.10.5270 | Trypanosoma brucei | no significant loss or gain of fitness in differentiation of procyclic to bloodstream forms | alsford |
CELE_Y54E10BL.6 | Caenorhabditis elegans | embryonic lethal | wormbase |
CELE_Y54E10BL.6 | Caenorhabditis elegans | larval arrest | wormbase |
CELE_Y54E10BL.6 | Caenorhabditis elegans | sterile | wormbase |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
Species | Known druggable target | Linked compounds | Reference |
---|---|---|---|
Homo sapiens | mitogen-activated protein kinase kinase 2 | Compounds | References |
Homo sapiens | mitogen-activated protein kinase kinase 1 | Compounds | References |
Mus musculus | mitogen-activated protein kinase kinase 1 | Compounds | References |
Species | Target | Length | Identity | Alignment span | Linked Drugs | Reference |
---|---|---|---|---|---|---|
Plasmodium falciparum (isolate 3D7) | Cell division control protein 2 homolog | 288 aa | 22.2% | 306 aa | Compounds | References |
Xenopus laevis | Aurora kinase B-A | 361 aa | 23.6% | 352 aa | Compounds | References |
Homo sapiens | Cyclin-dependent kinase 1/cyclin B1 | 297 aa | 26.4% | 242 aa | Compounds | References |