pI: 9.5346 |
Length (AA): 608 |
MW (Da): 68943 |
Paralog Number:
1
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 4 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
36 | 497 | 5y86 (A) | 142 | 528 | 25.00 | 0 | 1 | 0.592168 | 1.05 |
207 | 442 | 6gqm (A) | 619 | 927 | 21.00 | 0 | 0.96 | 0.666058 | -0.38 |
220 | 497 | 3ddq (C) | 43 | 291 | 47.00 | 0 | 1 | 0.696737 | 0.31 |
222 | 381 | 1u59 (A) | 380 | 534 | 26.00 | 0.0000085 | 0.76 | 0.505658 | 0.24 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Ortholog group members (OG5_129229)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT5G63610 | 1 |
Brugia malayi | Bm1_33825 | Protein kinase domain containing protein |
Candida albicans | CaO19.794 | Cyclin-dependent serine/threonin protein kinase |
Candida albicans | CaO19.8413 | Cyclin-dependent serine/threonin protein kinase |
Caenorhabditis elegans | CELE_F39H11.3 | Protein CDK-8 |
Dictyostelium discoideum | DDB_G0267442 | CDK family protein kinase |
Drosophila melanogaster | Dmel_CG10572 | Cyclin-dependent kinase 8 |
Echinococcus granulosus | EgrG_000582700 | cyclin dependent kinase 19 |
Echinococcus multilocularis | EmuJ_000582700 | cyclin dependent kinase 19 |
Homo sapiens | ENSG00000132964 | cyclin-dependent kinase 8 |
Homo sapiens | ENSG00000155111 | cyclin-dependent kinase 19 |
Loa Loa (eye worm) | LOAG_06222 | gastrulation defective protein 1 |
Loa Loa (eye worm) | LOAG_06223 | CMGC/CDK/CDK8 protein kinase |
Mus musculus | ENSMUSG00000029635 | cyclin-dependent kinase 8 |
Mus musculus | ENSMUSG00000038481 | cyclin-dependent kinase 19 |
Oryza sativa | 4349519 | Os10g0580300 |
Saccharomyces cerevisiae | YPL042C | Ssn3p |
Schistosoma japonicum | Sjp_0034250 | ko:K02208 cyclin-dependent kinase 8/11, putative |
Schistosoma mansoni | Smp_156990 | serine/threonine protein kinase |
Schmidtea mediterranea | mk4.001470.03 | Cdk11-like protein |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
CELE_F39H11.3 | Caenorhabditis elegans | embryonic lethal | wormbase |
CELE_F39H11.3 | Caenorhabditis elegans | larval lethal | wormbase |
CELE_F39H11.3 | Caenorhabditis elegans | slow growth | wormbase |
CELE_F39H11.3 | Caenorhabditis elegans | sterile | wormbase |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
Species | Known druggable target | Linked compounds | Reference |
---|---|---|---|
Homo sapiens | cyclin-dependent kinase 8 | Compounds | References |
Homo sapiens | cyclin-dependent kinase 19 | Compounds | References |
Species | Target | Length | Identity | Alignment span | Linked Drugs | Reference |
---|---|---|---|---|---|---|
Homo sapiens | Cyclin-dependent kinase 1/cyclin B1 | 297 aa | 38.3% | 274 aa | Compounds | References |
Plasmodium falciparum (isolate 3D7) | Cell division control protein 2 homolog | 288 aa | 37.5% | 275 aa | Compounds | References |
Patiria pectinifera | Cdc2 | 300 aa | 36.6% | 273 aa | Compounds | References |
Oryctolagus cuniculus | Cyclin-dependent kinase 4 | 189 aa | 41.0% | 173 aa | Compounds | References |
Sus scrofa | Glycogen synthase kinase 3 beta | 420 aa | 25.6% | 352 aa | Compounds | References |
Schizosaccharomyces pombe 972h- | Casein kinase II subunit alpha | 332 aa | 27.1% | 277 aa | Compounds | References |
Rattus norvegicus | Cell division protein kinase 5 | 292 aa | 37.6% | 274 aa | Compounds | References |
Rattus norvegicus | Mitogen-activated protein kinase 1 | 358 aa | 32.2% | 301 aa | Compounds | References |