Detailed view for CaO19.12198

Basic information

TDR Targets ID: 648832
Candida albicans, vacuolar alkaline phosphatase
Source Database / ID:  KEGG  

pI: 5.9817 | Length (AA): 551 | MW (Da): 60737 | Paralog Number: 3

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 1

Druggability Group : DG

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00245   Alkaline phosphatase

Gene Ontology

Mouse over links to read term descriptions.
GO:0016791   phosphoric monoester hydrolase activity  
GO:0003824   catalytic activity  
GO:0008152   metabolic process  

Metabolic Pathways

Folate biosynthesis (KEGG)
Global map (KEGG)

Structural information

Modbase 3D models:

There are 3 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
65 521 2x98 (A) 45 473 28.00 0 1 1.0689 -0.2
68 366 3wbh (A) 4 315 36.00 0 1 0.94365 -0.89
70 509 3a52 (A) 3 388 36.00 0 1 1.11955 -0.19

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_126976)

Species Accession Gene Product
Candida albicans CaO19.984   alkaline phosphatase
Candida albicans CaO19.4736   vacuolar alkaline phosphatase
Candida albicans CaO19.12198   vacuolar alkaline phosphatase
Candida albicans CaO19.8599   alkaline phosphatase
Dictyostelium discoideum DDB_G0278495   alkaline phosphatase
Drosophila melanogaster Dmel_CG1462   Alkaline phosphatase 4
Drosophila melanogaster Dmel_CG10592   CG10592 gene product from transcript CG10592-RA
Drosophila melanogaster Dmel_CG10827   CG10827 gene product from transcript CG10827-RA
Drosophila melanogaster Dmel_CG16771   CG16771 gene product from transcript CG16771-RE
Drosophila melanogaster Dmel_CG5656   CG5656 gene product from transcript CG5656-RA
Drosophila melanogaster Dmel_CG8105   CG8105 gene product from transcript CG8105-RA
Drosophila melanogaster Dmel_CG5150   CG5150 gene product from transcript CG5150-RB
Drosophila melanogaster Dmel_CG1809   CG1809 gene product from transcript CG1809-RA
Drosophila melanogaster Dmel_CG8147   CG8147 gene product from transcript CG8147-RA
Escherichia coli b0383   bacterial alkaline phosphatase
Echinococcus granulosus EgrG_000752800   alkaline phosphatase intestinal gene 2
Echinococcus granulosus EgrG_000752700   intestinal type alkaline phosphatase
Echinococcus granulosus EgrG_000393300   intestinal type alkaline phosphatase 1
Echinococcus granulosus EgrG_000393400   alkaline phosphatase
Echinococcus multilocularis EmuJ_000752700   intestinal type alkaline phosphatase
Echinococcus multilocularis EmuJ_000393300   intestinal type alkaline phosphatase 1
Echinococcus multilocularis EmuJ_000393400   alkaline phosphatase
Echinococcus multilocularis EmuJ_000752800   alkaline phosphatase, intestinal, gene 2
Homo sapiens ENSG00000162551   alkaline phosphatase, liver/bone/kidney
Homo sapiens ENSG00000163295   alkaline phosphatase, intestinal
Homo sapiens ENSG00000163286   alkaline phosphatase, placental-like 2
Homo sapiens ENSG00000163283   alkaline phosphatase, placental
Mus musculus ENSMUSG00000079440   alkaline phosphatase, intestinal
Mus musculus ENSMUSG00000026246   alkaline phosphatase, placental-like 2
Mus musculus ENSMUSG00000028766   alkaline phosphatase, liver/bone/kidney
Mus musculus ENSMUSG00000036500   alkaline phosphatase 3, intestine, not Mn requiring
Saccharomyces cerevisiae YDR481C   Pho8p
Schistosoma japonicum Sjp_0067880   Alkaline phosphatase, tissue-nonspecific isozyme precursor, putative
Schistosoma japonicum Sjp_0132130   ko:K01077 alkaline phosphatase [EC3.1.3.1], putative
Schistosoma mansoni Smp_145290   alkaline phosphatase
Schistosoma mansoni Smp_155890   alkaline phosphatase
Schistosoma mansoni Smp_155900   hypothetical protein
Schmidtea mediterranea mk4.001506.02  
Schmidtea mediterranea mk4.013780.01  
Schmidtea mediterranea mk4.003396.00  
Schmidtea mediterranea mk4.013780.00  
Schmidtea mediterranea mk4.001506.01  
Schmidtea mediterranea mk4.001877.09  
Schmidtea mediterranea mk4.001877.11  
Schmidtea mediterranea mk4.001877.10  

Essentiality

CaO19.12198 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
b0383 Escherichia coli non-essential goodall
Show/Hide essentiality data references
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Homo sapiens alkaline phosphatase, placental Compounds References
Mus musculus alkaline phosphatase, liver/bone/kidney Compounds References
Homo sapiens alkaline phosphatase, liver/bone/kidney Compounds References
Mus musculus alkaline phosphatase 3, intestine, not Mn requiring Compounds References
Bos taurus Alkaline phosphatase, tissue-nonspecific isozyme Compounds References
Homo sapiens alkaline phosphatase, placental-like 2 Compounds References
Bos taurus Intestinal alkaline phosphatase Compounds References
Homo sapiens alkaline phosphatase, intestinal Compounds References
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier CaO19.12198 (Candida albicans), vacuolar alkaline phosphatase
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