Detailed view for CaO19.12570

Basic information

TDR Targets ID: 649519
Candida albicans, 3' exon of potential Low molecular weight phosphoTyrosine Phosphatase gene
Source Database / ID:  KEGG  

pI: 6.8437 | Length (AA): 114 | MW (Da): 13093 | Paralog Number: 1

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF01451   Low molecular weight phosphotyrosine protein phosphatase

Gene Ontology

Mouse over links to read term descriptions.
GO:0004725   protein tyrosine phosphatase activity  
GO:0006470   protein amino acid dephosphorylation  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 2 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
1 114 1d1q (A) 22 136 52.00 0 1 1.6074 0.06
55 99 3oq9 (A) 229 274 20.00 0 0.43 0.674937 -0.76

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_127571)

Species Accession Gene Product
Arabidopsis thaliana AT3G44620   protein-tyrosine phosphatase
Brugia malayi Bm1_37740   Low molecular weight phosphotyrosine protein phosphatase containing protein
Candida albicans CaO19.5104   C terminus of potential Low molecular weight phosphoTyrosine Phosphatase
Candida albicans CaO19.12570   3' exon of potential Low molecular weight phosphoTyrosine Phosphatase gene
Caenorhabditis elegans CELE_Y94H6A.7   Protein Y94H6A.7
Dictyostelium discoideum DDB_G0267484   acid phosphatase 1
Drosophila melanogaster Dmel_CG33748   CG33748 gene product from transcript CG33748-RA
Drosophila melanogaster Dmel_CG33747   CG33747 gene product from transcript CG33747-RC
Drosophila melanogaster Dmel_CG31469   CG31469 gene product from transcript CG31469-RA
Escherichia coli b2061   colanic acid production protein-tyrosine-phosphatase
Escherichia coli b0982   Protein-tyrosine-phosphatase, role in O-antigen capsule formation
Entamoeba histolytica EHI_103800   protein tyrosine phosphatase, putative
Entamoeba histolytica EHI_153650   protein tyrosine phosphatase, putative
Giardia lamblia GL50803_14456   Low molecular weight protein-tyrosine-phosphatase
Homo sapiens ENSG00000143727   acid phosphatase 1, soluble
Loa Loa (eye worm) LOAG_09034   phosphotyrosine protein phosphatase
Mus musculus 102642088   low molecular weight phosphotyrosine protein phosphatase-like
Mus musculus ENSMUSG00000044573   acid phosphatase 1, soluble
Mycobacterium tuberculosis Rv2234   Phosphotyrosine protein phosphatase PtpA (protein-tyrosine-phosphatase) (PTPase) (LMW phosphatase)
Mycobacterium ulcerans MUL_1319   phosphotyrosine protein phosphatase PtpA
Oryza sativa 4346297   Os08g0557400
Onchocerca volvulus OVOC4340  
Saccharomyces cerevisiae YPR073C   Ltp1p
Trichomonas vaginalis TVAG_388870   low molecular weight protein-tyrosine-phosphatase, putative
Trichomonas vaginalis TVAG_458720   low molecular weight protein-tyrosine-phosphatase, putative
Trichomonas vaginalis TVAG_350160   low molecular weight protein tyrosine phosphatase, putative
Trichomonas vaginalis TVAG_174880   low molecular weight protein tyrosine phosphatase, putative
Trichomonas vaginalis TVAG_376230   low molecular weight protein tyrosine phosphatase, putative
Trichomonas vaginalis TVAG_005380   low molecular weight protein-tyrosine-phosphatase, putative

Essentiality

CaO19.12570 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
b0982 Escherichia coli non-essential goodall
b2061 Escherichia coli non-essential goodall
Show/Hide essentiality data references
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Mycobacterium tuberculosis Phosphotyrosine protein phosphatase PtpA (protein-tyrosine-phosphatase) (PTPase) (LMW phosphatase) Compounds References
Bos taurus Low molecular weight phosphotyrosine protein phosphatase Compounds References
Influenza A virus Neuraminidase Compounds References
Saccharomyces cerevisiae Ltp1p Compounds References
Influenza A virus Neuraminidase Compounds References
Homo sapiens acid phosphatase 1, soluble Compounds References
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier CaO19.12570 (Candida albicans), 3' exon of potential Low molecular weight phosphoTyrosine Phosphatase gene
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