Detailed view for CaO19.5224

Basic information

TDR Targets ID: 650509
Candida albicans, similar to S. cerevisiae protein kinases PKH1 (YDR490C) and PKH2 (YOL100W) involved in MAPKKK cascade
Source Database / ID:  KEGG  

pI: 8.1434 | Length (AA): 944 | MW (Da): 106213 | Paralog Number: 1

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00069   Protein kinase domain

Gene Ontology

Mouse over links to read term descriptions.
GO:0005524   ATP binding  
GO:0004672   protein kinase activity  
GO:0006468   protein amino acid phosphorylation  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 2 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
154 689 1ym7 (A) 116 644 21.00 0 1 0.622097 0.57
233 523 4c0t (A) 233 523 99.99 0 1 1.52226 -1.31

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_128785)

Species Accession Gene Product
Arabidopsis thaliana AT3G10540   3-phosphoinositide-dependent protein kinase
Arabidopsis thaliana AT5G04510   3'-phosphoinositide-dependent protein kinase 1
Brugia malayi Bm1_30965   Protein kinase domain containing protein
Brugia malayi Bm1_28150   phosphoinositide-dependent protein kinase I
Candida albicans CaO19.5224   similar to S. cerevisiae protein kinases PKH1 (YDR490C) and PKH2 (YOL100W) involved in MAPKKK cascade
Candida albicans CaO19.12690   similar to S. cerevisiae protein kinases PKH1 (YDR490C) and PKH2 (YOL100W) involved in MAPKKK cascade
Caenorhabditis elegans CELE_H42K12.1   Protein PDK-1, isoform B
Caenorhabditis elegans CELE_W04B5.5   Protein W04B5.5
Dictyostelium discoideum DDB_G0284489   PDK1 family protein kinase
Dictyostelium discoideum DDB_G0277145   PKA family protein kinase
Drosophila melanogaster Dmel_CG1210   Phosphoinositide-dependent kinase 1
Echinococcus granulosus EgrG_000723900   3-phosphoinositide-dependent protein kinase 1
Entamoeba histolytica EHI_095940   protein kinase, putative
Echinococcus multilocularis EmuJ_000723900   3 phosphoinositide dependent protein kinase 1
Homo sapiens 101060747   3-phosphoinositide-dependent protein kinase 1-like
Homo sapiens ENSG00000140992   3-phosphoinositide dependent protein kinase 1
Loa Loa (eye worm) LOAG_09248   AGC/PDK1 protein kinase
Loa Loa (eye worm) LOAG_03280   AGC/PDK1 protein kinase
Mus musculus ENSMUSG00000024122   3-phosphoinositide dependent protein kinase 1
Oryza sativa 4324953   Os01g0872800
Saccharomyces cerevisiae YDR490C   Pkh1p
Saccharomyces cerevisiae YOL100W   Pkh2p
Schistosoma japonicum Sjp_0035230   ko:K06276 3-phosphoinositide dependent protein kinase-1, putative
Schistosoma mansoni Smp_094250   serine/threonine protein kinase
Schmidtea mediterranea mk4.007072.00   3-phosphoinositide-dependent protein kinase 1
Trichomonas vaginalis TVAG_240510   AGC family protein kinase
Trichomonas vaginalis TVAG_366130   AGC family protein kinase
Trichomonas vaginalis TVAG_035920   AGC family protein kinase

Essentiality

CaO19.5224 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
CELE_W04B5.5 Caenorhabditis elegans embryonic lethal wormbase
CELE_W04B5.5 Caenorhabditis elegans larval arrest wormbase
CELE_W04B5.5 Caenorhabditis elegans sterile wormbase
YOL100W Saccharomyces cerevisiae inviable yeastgenome
Show/Hide essentiality data references
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Homo sapiens 3-phosphoinositide dependent protein kinase 1 Compounds References
By sequence similarity to non orthologous druggable targets
Species Target Length Identity Alignment span Linked Drugs Reference
Plasmodium falciparum (isolate 3D7) Cell division control protein 2 homolog 288 aa 26.9% 308 aa Compounds References
Rattus norvegicus Jak1 protein 210 aa 22.8% 197 aa Compounds References
Patiria pectinifera Cdc2 300 aa 27.4% 310 aa Compounds References
Rattus norvegicus MAP kinase p38 alpha 360 aa 26.2% 324 aa Compounds References
Rattus norvegicus Serine/threonine-protein kinase pim-3 326 aa 27.8% 273 aa Compounds References
Rattus norvegicus Cell division protein kinase 5 292 aa 25.0% 304 aa Compounds References
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier CaO19.5224 (Candida albicans), similar to S. cerevisiae protein kinases PKH1 (YDR490C) and PKH2 (YOL100W) involved in MAPKKK cascade
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