Detailed view for CaO19.11956

Basic information

TDR Targets ID: 651532
Candida albicans, aryl alcohol dehydrogenase
Source Database / ID:  KEGG  

pI: 6.2419 | Length (AA): 344 | MW (Da): 39077 | Paralog Number: 10

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00248   Aldo/keto reductase family

Gene Ontology

Mouse over links to read term descriptions.
No GO information for this protein.

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 5 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
2 344 4xo6 (A) 0 321 22.00 0 1 0.939793 0.32
5 333 1zgd (A) 7 292 23.00 0 1 0.932095 0.29
7 335 1lqa (A) 1 339 20.00 0 1 1.1671 -0.56
9 338 3eau (A) 39 359 31.00 0 1 1.318 -0.54
11 342 3v0s (A) 5 336 36.00 0 1 1.12102 0.56

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_126648)

Species Accession Gene Product
Arabidopsis thaliana AT1G04690   potassium channel beta subunit 1
Babesia bovis BBOV_IV000130   aldo-keto reductase
Candida albicans CaO19.11956   aryl alcohol dehydrogenase
Candida albicans CaO19.1048   putative aryl alcohol dehydrogenase
Candida albicans CaO19.771   aryl alcohol dehydrogenase, aromatic degradation
Candida albicans CaO19.4476   aryl alcohol dehydrogenase
Candida albicans CaO19.8650   putative aryl alcohol dehydrogenase
Candida albicans CaO19.10821   oxidoreductase
Candida albicans CaO19.8393   Possible Aldo/keto reductase
Candida albicans CaO19.11957   aryl alcohol dehydrogenase
Candida albicans CaO19.3311   oxidoreductase
Candida albicans CaO19.4477   aryl alcohol dehydrogenase
Candida albicans CaO19.629   similar to putative aryl alcohol dehydrogenase family
Drosophila melanogaster Dmel_CG43388   Hyperkinetic
Escherichia coli b0419   2-carboxybenzaldehyde reductase
Escherichia coli b3001   L-glyceraldehyde 3-phosphate reductase
Echinococcus granulosus EgrG_000822300   voltage gated potassium channel subunit
Echinococcus multilocularis EmuJ_000822300   voltage gated potassium channel subunit
Homo sapiens ENSG00000069424   potassium voltage-gated channel, shaker-related subfamily, beta member 2
Homo sapiens ENSG00000169282   potassium voltage-gated channel, shaker-related subfamily, beta member 1
Homo sapiens ENSG00000170049   potassium voltage-gated channel, shaker-related subfamily, beta member 3
Mus musculus ENSMUSG00000028931   potassium voltage-gated channel, shaker-related subfamily, beta member 2
Mus musculus ENSMUSG00000027827   potassium voltage-gated channel, shaker-related subfamily, beta member 1
Mus musculus ENSMUSG00000018470   potassium voltage-gated channel, shaker-related subfamily, beta member 3
Mycobacterium tuberculosis Rv2298   Conserved protein
Mycobacterium ulcerans MUL_2745   hypothetical protein
Neospora caninum NCLIV_002950   hypothetical protein
Oryza sativa 4331148   Os02g0817500
Plasmodium berghei PBANKA_1140500   aldehyde reductase, putative
Plasmodium falciparum PF3D7_1364600   aldehyde reductase, putative
Plasmodium knowlesi PKNH_1106700   aldehyde reductase, putative
Plasmodium vivax PVX_115190   aldehyde reductase, putative
Plasmodium yoelii PY02780   aldo-keto reductase
Saccharomyces cerevisiae YPL088W   aldo-keto reductase superfamily protein
Schistosoma japonicum Sjp_0070330   Voltage-gated potassium channel subunit beta-2, putative
Schistosoma japonicum Sjp_0304920   ko:K04882 potassium voltage-gated channel, Shaker-related subfamily A, beta, putative
Schistosoma mansoni Smp_012380   potassium channel beta
Schmidtea mediterranea mk4.000927.05  
Schmidtea mediterranea mk4.020618.01   Putative potassium channel beta
Toxoplasma gondii TGME49_208040   aldo-keto reductase
Theileria parva TP02_0941   aldo-keto reductase, putative

Essentiality

CaO19.11956 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
mtu2333 Mycobacterium tuberculosis non-essential nmpdr
b0419 Escherichia coli non-essential goodall
b3001 Escherichia coli non-essential goodall
TGME49_208040 Toxoplasma gondii Probably essential sidik
Show/Hide essentiality data references
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Homo sapiens potassium voltage-gated channel, shaker-related subfamily, beta member 1 Compounds References
By sequence similarity to non orthologous druggable targets
Species Target Length Identity Alignment span Linked Drugs Reference
Sus scrofa Aldose reductase 316 aa 18.5% 324 aa Compounds References
Sus scrofa Aldehyde reductase 325 aa 19.2% 328 aa Compounds References
Bos taurus Aldose reductase 315 aa 18.2% 319 aa Compounds References
Rattus norvegicus Aldose reductase-related protein 1 316 aa 21.0% 319 aa Compounds References
Rattus norvegicus Aldose reductase 316 aa 19.4% 320 aa Compounds References
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier CaO19.11956 (Candida albicans), aryl alcohol dehydrogenase
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