Detailed view for CaO19.8464

Basic information

TDR Targets ID: 652166
Candida albicans, likely MAPKKK similar to S. cerevisiae STE11 (YLR362W) MAPKKK of the pheromone response pathway
Source Database / ID:  KEGG  

pI: 5.9904 | Length (AA): 823 | MW (Da): 91361 | Paralog Number: 1

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00069   Protein kinase domain
PF00536   SAM domain (Sterile alpha motif)
PF14847   Ras-binding domain of Byr2

Gene Ontology

Mouse over links to read term descriptions.
GO:0005524   ATP binding  
GO:0005515   protein binding  
GO:0004672   protein kinase activity  
GO:0006468   protein amino acid phosphorylation  

Metabolic Pathways

MAPK signaling pathway - yeast (KEGG)

Structural information

Modbase 3D models:

No model available for this protein in Modbase.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_128416)

Species Accession Gene Product
Arabidopsis thaliana AT1G09000   mitogen-activated protein kinase kinase kinase ANP1
Arabidopsis thaliana AT3G06030   mitogen-activated protein kinase kinase kinase 3
Arabidopsis thaliana AT1G54960   NPK1-related protein kinase 2
Brugia malayi Bm1_11350   Protein kinase domain containing protein
Candida albicans CaO19.8464   likely MAPKKK similar to S. cerevisiae STE11 (YLR362W) MAPKKK of the pheromone response pathway
Candida albicans CaO19.844   likely MAPKKK similar to S. cerevisiae STE11 (YLR362W) MAPKKK of the pheromone response pathway
Dictyostelium discoideum DDB_G0283265   F-box-containing protein
Echinococcus granulosus EgrG_000389600   mitogen activated protein kinase kinase kinase
Echinococcus multilocularis EmuJ_000389600   mitogen activated protein kinase kinase kinase
Homo sapiens ENSG00000169967   mitogen-activated protein kinase kinase kinase 2
Homo sapiens ENSG00000198909   mitogen-activated protein kinase kinase kinase 3
Homo sapiens ENSG00000176601   mitogen-activated protein kinase kinase kinase 19
Loa Loa (eye worm) LOAG_05805   STE/STE11/MEKK2 protein kinase
Mus musculus ENSMUSG00000024383   mitogen-activated protein kinase kinase kinase 2
Mus musculus ENSMUSG00000020700   mitogen-activated protein kinase kinase kinase 3
Mus musculus ENSMUSG00000051590   mitogen-activated protein kinase kinase kinase 19
Oryza sativa 4345595   Os08g0421800
Oryza sativa 4346940   Os09g0383300
Onchocerca volvulus OVOC11755  
Saccharomyces cerevisiae YLR362W   Ste11p
Schistosoma japonicum Sjp_0018650   ko:K04416 mitogen-activated protein kinase kinase kinase 1, putative
Schistosoma mansoni Smp_050380   protein kinase
Schmidtea mediterranea mk4.012560.04   Serine/threonine-protein kinase flr-4
Schmidtea mediterranea mk4.003911.08   Serine/threonine-protein kinase flr-4
Schmidtea mediterranea mk4.000848.07   Serine/threonine-protein kinase flr-4
Schmidtea mediterranea mk4.004421.00  
Schmidtea mediterranea mk4.001978.02   Serine/threonine-protein kinase PAK mbt
Schmidtea mediterranea mk4.009148.02   Serine/threonine-protein kinase flr-4
Schmidtea mediterranea mk4.000265.07   Serine/threonine-protein kinase flr-4
Schmidtea mediterranea mk4.000517.02   Serine/threonine-protein kinase flr-4
Schmidtea mediterranea mk4.005767.00  
Schmidtea mediterranea mk4.001734.00  
Schmidtea mediterranea mk4.000652.08   Serine/threonine-protein kinase flr-4
Schmidtea mediterranea mk4.017614.00  
Schmidtea mediterranea mk4.000165.17  
Schmidtea mediterranea mk4.000049.07   Serine/threonine-protein kinase flr-4
Schmidtea mediterranea mk4.001445.01   Mitogen-activated protein kinase kinase kinase 19
Schmidtea mediterranea mk4.000848.08  
Schmidtea mediterranea mk4.002610.01  
Schmidtea mediterranea mk4.002795.01  
Schmidtea mediterranea mk4.001800.02   Serine/threonine-protein kinase flr-4
Schmidtea mediterranea mk4.006618.00  
Schmidtea mediterranea mk4.001330.04   Serine/threonine-protein kinase flr-4
Schmidtea mediterranea mk4.000239.01   Serine/threonine-protein kinase PAK mbt
Schmidtea mediterranea mk4.001605.00   Serine/threonine-protein kinase flr-4
Schmidtea mediterranea mk4.006212.02  

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Homo sapiens mitogen-activated protein kinase kinase kinase 19 Compounds References
Homo sapiens mitogen-activated protein kinase kinase kinase 2 Compounds References
Homo sapiens mitogen-activated protein kinase kinase kinase 3 Compounds References
By sequence similarity to non orthologous druggable targets
Species Target Length Identity Alignment span Linked Drugs Reference
Oryctolagus cuniculus Cyclin-dependent kinase 4 189 aa 32.7% 171 aa Compounds References
Patiria pectinifera Cdc2 300 aa 30.6% 242 aa Compounds References
Rattus norvegicus Cell division protein kinase 5 292 aa 27.9% 247 aa Compounds References
Homo sapiens Cyclin-dependent kinase 1/cyclin B1 297 aa 30.0% 260 aa Compounds References
Plasmodium falciparum (isolate 3D7) Cell division control protein 2 homolog 288 aa 30.8% 237 aa Compounds References
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier CaO19.8464 (Candida albicans), likely MAPKKK similar to S. cerevisiae STE11 (YLR362W) MAPKKK of the pheromone response pathway
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