Detailed view for CaO19.583

Basic information

TDR Targets ID: 652184
Candida albicans, similar to indoleamine 2,3-dioxygenases
Source Database / ID:  KEGG  

pI: 6.5039 | Length (AA): 440 | MW (Da): 49798 | Paralog Number: 1

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF01231   Indoleamine 2,3-dioxygenase

Gene Ontology

Mouse over links to read term descriptions.
GO:0019441   tryptophan catabolic process to kynurenine  
GO:0020037   heme binding  
GO:0046872   metal ion binding  

Metabolic Pathways

Tryptophan metabolism (KEGG)
Global map (KEGG)

Structural information

Modbase 3D models:

No model available for this protein in Modbase.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_130288)

Species Accession Gene Product
Brugia malayi Bm1_01790   indoleamine 2,3-dioxygenase
Candida albicans CaO19.583   similar to indoleamine 2,3-dioxygenases
Candida albicans CaO19.8215   similar to indoleamine 2,3-dioxygenases
Echinococcus granulosus EgrG_000587500   indoleamine 23 dioxygenase 2
Echinococcus multilocularis EmuJ_000587500   indoleamine 2,3 dioxygenase 2
Homo sapiens ENSG00000188676   indoleamine 2,3-dioxygenase 2
Homo sapiens 3620   indoleamine 2,3-dioxygenase 1
Loa Loa (eye worm) LOAG_11225   indoleamine 2,3-dioxygenase
Mus musculus ENSMUSG00000031551   indoleamine 2,3-dioxygenase 1
Mus musculus ensembl-mmu:ENSMUSG00000031549   indoleamine 2,3-dioxygenase 2
Saccharomyces cerevisiae YJR078W   dioxygenase BNA2
Schistosoma japonicum Sjp_0313070   ko:K00463 indoleamine 2,3-dioxygenase, putative
Schistosoma japonicum Sjp_0001690   IPR000898,Indoleamine 2,3-dioxygenase,domain-containing
Schistosoma mansoni Smp_133900   hypothetical protein
Schistosoma mansoni Smp_133890   hypothetical protein

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Homo sapiens indoleamine 2,3-dioxygenase 1 Compounds References
Mus musculus indoleamine 2,3-dioxygenase 1 Compounds References
Homo sapiens indoleamine 2,3-dioxygenase 2 Compounds References
Mus musculus indoleamine 2,3-dioxygenase 2 Compounds References
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier CaO19.583 (Candida albicans), similar to indoleamine 2,3-dioxygenases
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