pI: 4.8901 |
Length (AA): 587 |
MW (Da): 66623 |
Paralog Number:
1
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There is 1 model calculated for this protein. More info on
this model, including the
model itself is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
110 | 580 | 4yde (B) | 110 | 580 | 99.99 | 0 | 1 | 1.87268 | -1.21 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Ortholog group members (OG5_128081)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT5G40280 | farnesyltransferase subunit beta |
Babesia bovis | BBOV_III004550 | prenyltransferase and squalene oxidase repeat family protein |
Brugia malayi | Bm1_50565 | Prenyltransferase and squalene oxidase repeat family protein |
Candida albicans | CaO19.12513 | similar to S. cerevisiae RAM1 (YDL090C) beta subunit of farnesyl transferase (Ram1p+Ram2p), involved in prenylation of RAS prote |
Candida albicans | CaO19.5046 | similar to S. cerevisiae RAM1 (YDL090C) beta subunit of farnesyl transferase (Ram1p+Ram2p), involved in prenylation of RAS prote |
Caenorhabditis elegans | CELE_F23B12.6 | Protein FNTB-1 |
Cryptosporidium hominis | Chro.10227 | chain B, structure of fpt bound to ggpp |
Cryptosporidium parvum | cgd1_1980 | protein geranyl-geranyltransferase beta subunit |
Dictyostelium discoideum | DDB_G0270948 | protein farnesyltransferase beta subunit |
Drosophila melanogaster | Dmel_CG17565 | CG17565 gene product from transcript CG17565-RA |
Echinococcus granulosus | EgrG_000512700 | protein farnesyltransferase subunit beta |
Entamoeba histolytica | EHI_006190 | protein farnesyltransferase beta subunit, putative |
Echinococcus multilocularis | EmuJ_000512700 | protein farnesyltransferase subunit beta |
Giardia lamblia | GL50803_9382 | Prenyltransferase |
Homo sapiens | 100529261 | CHURC1-FNTB readthrough |
Homo sapiens | ENSG00000257365 | farnesyltransferase, CAAX box, beta |
Leishmania braziliensis | LbrM.26.1490 | farnesyltransferase beta subunit |
Leishmania donovani | LdBPK_261450.1 | farnesyltransferase beta subunit |
Leishmania infantum | LinJ.26.1450 | farnesyltransferase beta subunit |
Leishmania major | LmjF.26.1470 | farnesyltransferase beta subunit |
Leishmania mexicana | LmxM.26.1470 | farnesyltransferase beta subunit |
Loa Loa (eye worm) | LOAG_01284 | prenyltransferase and squalene oxidase repeat family protein |
Mus musculus | 102643287 | protein farnesyltransferase subunit beta-like |
Mus musculus | ENSMUSG00000033373 | farnesyltransferase, CAAX box, beta |
Neospora caninum | NCLIV_038220 | protein farnesyltranstransferase beta subunit, putative |
Oryza sativa | 4327880 | Os01g0737800 |
Plasmodium berghei | PBANKA_0901600 | protein farnesyltransferase subunit beta, putative |
Plasmodium falciparum | PF3D7_1147500 | protein farnesyltransferase subunit beta |
Plasmodium knowlesi | PKNH_0945400 | protein farnesyltransferase subunit beta, putative |
Plasmodium knowlesi | PKNH_0945300 | conserved Plasmodium protein, unknown function |
Plasmodium vivax | PVX_092962 | farnesyltransferase beta subunit, putative |
Plasmodium vivax | PVX_092958 | conserved Plasmodium protein, unknown function |
Plasmodium yoelii | PY02409 | Prenyltransferase and squalene oxidase repeat, putative |
Saccharomyces cerevisiae | YDL090C | protein farnesyltransferase |
Schistosoma japonicum | Sjp_0215430 | ko:K05954 farnesyltransferase, CAAX box, beta [EC:2.5.1.58], putative |
Schistosoma mansoni | Smp_065780 | protein farnesyltransferase subunit beta |
Schmidtea mediterranea | mk4.001561.00 | |
Trypanosoma brucei gambiense | Tbg972.7.310 | protein farnesyltransferase beta subunit, putative |
Trypanosoma brucei | Tb927.7.460 | protein farnesyltransferase beta subunit |
Trypanosoma cruzi | TcCLB.507747.220 | protein farnesyltransferase, putative |
Trypanosoma cruzi | TcCLB.503723.70 | protein farnesyltransferase, putative |
Toxoplasma gondii | TGME49_200370 | prenyltransferase and squalene oxidase repeat-containing protein |
Theileria parva | TP02_0810 | farnesyltransferase beta subunit, putative |
Trichomonas vaginalis | TVAG_366000 | geranylgeranyl transferase type II beta subunit, putative |
Trichomonas vaginalis | TVAG_464130 | geranylgeranyl transferase type II beta subunit, putative |
Trichomonas vaginalis | TVAG_462400 | geranylgeranyl transferase type II beta subunit, putative |
Trichomonas vaginalis | TVAG_151840 | type I geranylgeranyltransferase beta subunit, putative |
Trichomonas vaginalis | TVAG_338240 | geranylgeranyl transferase type beta subunit, putative |
Trichomonas vaginalis | TVAG_021630 | geranylgeranyl transferase type I beta subunit, putative |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
Tb927.7.460 | Trypanosoma brucei | no significant loss or gain of fitness in bloodstream forms (3 days) | alsford |
Tb927.7.460 | Trypanosoma brucei | no significant loss or gain of fitness in bloodstream forms (6 days) | alsford |
Tb927.7.460 | Trypanosoma brucei | significant loss of fitness in procyclic forms | alsford |
Tb927.7.460 | Trypanosoma brucei | significant loss of fitness in differentiation of procyclic to bloodstream forms | alsford |
CELE_F23B12.6 | Caenorhabditis elegans | embryonic lethal | wormbase |
PBANKA_0901600 | Plasmodium berghei | Essential | plasmo |
TGME49_200370 | Toxoplasma gondii | Essentiality uncertain | sidik |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
Species | Known druggable target | Linked compounds | Reference |
---|---|---|---|
Trypanosoma cruzi | protein farnesyltransferase, putative | Compounds | References |
Homo sapiens | farnesyltransferase, CAAX box, beta | Compounds | References |
Mus musculus | farnesyltransferase, CAAX box, beta | Compounds | References |
Saccharomyces cerevisiae | protein farnesyltransferase | Compounds | References |
Bos taurus | Protein farnesyltransferase | Compounds | References |
Rattus norvegicus | Protein farnesyltransferase | Compounds | References |
Trypanosoma cruzi | protein farnesyltransferase, putative | Compounds | References |
Species | Target | Length | Identity | Alignment span | Linked Drugs | Reference |
---|---|---|---|---|---|---|
Bos taurus | Geranylgeranyl transferase type I | 377 aa | 24.2% | 360 aa | Compounds | References |
Rattus norvegicus | geranylgeranyltransferase type-I | 377 aa | 24.2% | 376 aa | Compounds | References |