pI: 5.3657 |
Length (AA): 499 |
MW (Da): 54011 |
Paralog Number:
3
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 3 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
5 | 499 | 1bi9 (A) | 4 | 499 | 46.00 | 0 | 1 | 1.53418 | -0.41 |
12 | 499 | 1ag8 (A) | 8 | 499 | 47.00 | 0 | 1 | 1.61016 | -1 |
20 | 495 | 4qf6 (A) | 16 | 493 | 51.00 | 0 | 1 | 1.64711 | -1.15 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Ortholog group members (OG5_126638)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT3G48000 | aldehyde dehydrogenase 2B4 |
Arabidopsis thaliana | AT2G24270 | NADP-dependent glyceraldehyde-3-phosphate dehydrogenase |
Arabidopsis thaliana | AT1G23800 | aldehyde dehydrogenase 2B7 |
Arabidopsis thaliana | AT3G24503 | aldehyde dehydrogenase 2C4 |
Candida albicans | CaO19.5806 | aldehyde dehydrogenase |
Candida albicans | CaO19.13683 | Mitochondrial aldehyde dehydrogenase |
Candida albicans | CaO19.13228 | aldehyde dehydrogenase |
Candida albicans | CaO19.6306 | Mitochondrial aldehyde dehydrogenase |
Caenorhabditis elegans | CELE_F54D8.3 | Protein ALH-1, isoform B |
Caenorhabditis elegans | CELE_K04F1.15 | Protein ALH-2 |
Dictyostelium discoideum | DDB_G0290537 | aldehyde dehydrogenase |
Dictyostelium discoideum | DDB_G0290479 | aldehyde dehydrogenase |
Dictyostelium discoideum | DDB_G0290535 | aldehyde dehydrogenase |
Dictyostelium discoideum | DDB_G0288521 | aldehyde dehydrogenase |
Dictyostelium discoideum | DDB_G0270028 | aldehyde dehydrogenase |
Drosophila melanogaster | Dmel_CG31075 | CG31075 gene product from transcript CG31075-RA |
Drosophila melanogaster | Dmel_CG3752 | Aldehyde dehydrogenase |
Escherichia coli | b3588 | aldehyde dehydrogenase B |
Escherichia coli | b1300 | gamma-glutamyl-gamma-aminobutyraldehyde dehydrogenase |
Echinococcus granulosus | EgrG_000389100 | aldehyde dehydrogenase mitochondrial |
Echinococcus multilocularis | EmuJ_000389100 | aldehyde dehydrogenase, mitochondrial |
Homo sapiens | ENSG00000111275 | aldehyde dehydrogenase 2 family (mitochondrial) |
Homo sapiens | ENSG00000137124 | aldehyde dehydrogenase 1 family, member B1 |
Homo sapiens | ENSG00000184254 | aldehyde dehydrogenase 1 family, member A3 |
Homo sapiens | ENSG00000165092 | aldehyde dehydrogenase 1 family, member A1 |
Homo sapiens | ENSG00000128918 | aldehyde dehydrogenase 1 family, member A2 |
Leishmania braziliensis | LbrM.25.1100 | aldehyde dehydrogenase, mitochondrial precursor |
Leishmania donovani | LdBPK_251160.1 | aldehyde dehydrogenase, mitochondrial precursor |
Leishmania infantum | LinJ.25.1160 | aldehyde dehydrogenase, mitochondrial precursor |
Leishmania major | LmjF.25.1120 | aldehyde dehydrogenase, mitochondrial precursor |
Leishmania mexicana | LmxM.25.1120 | aldehyde dehydrogenase, mitochondrial precursor |
Mus musculus | ENSMUSG00000015134 | aldehyde dehydrogenase family 1, subfamily A3 |
Mus musculus | ENSMUSG00000053279 | aldehyde dehydrogenase family 1, subfamily A1 |
Mus musculus | ENSMUSG00000013584 | aldehyde dehydrogenase family 1, subfamily A2 |
Mus musculus | 11669 | aldehyde dehydrogenase 2, mitochondrial |
Mus musculus | ENSMUSG00000024747 | aldehyde dehydrogenase family 1, subfamily A7 |
Mus musculus | ENSMUSG00000035561 | aldehyde dehydrogenase 1 family, member B1 |
Mycobacterium tuberculosis | Rv0458 | Probable aldehyde dehydrogenase |
Mycobacterium ulcerans | MUL_2877 | aldehyde dehydrogenase |
Mycobacterium ulcerans | MUL_0494 | aldehyde dehydrogenase |
Mycobacterium ulcerans | MUL_1416 | aldehyde dehydrogenase |
Neospora caninum | NCLIV_005550 | hypothetical protein |
Oryza sativa | 4326375 | Os01g0591000 |
Oryza sativa | 4340725 | Os06g0270900 |
Oryza sativa | 4330612 | Os02g0730000 |
Oryza sativa | 4345685 | Os08g0440800 |
Oryza sativa | 4326376 | Os01g0591300 |
Saccharomyces cerevisiae | YMR169C | aldehyde dehydrogenase (NAD(+)) ALD3 |
Saccharomyces cerevisiae | YMR170C | aldehyde dehydrogenase (NAD(+)) ALD2 |
Saccharomyces cerevisiae | YER073W | aldehyde dehydrogenase (NAD(P)(+)) ALD5 |
Saccharomyces cerevisiae | YOR374W | aldehyde dehydrogenase (NADP(+)) ALD4 |
Schistosoma japonicum | Sjp_0208240 | ko:K00128 aldehyde dehydrogenase (NAD+) [EC1.2.1.3], putative |
Schistosoma japonicum | Sjp_0133930 | Aldehyde dehydrogenase, mitochondrial precursor, putative |
Schistosoma japonicum | Sjp_0011180 | Retinal dehydrogenase 1, putative |
Schistosoma japonicum | Sjp_0103820 | Aldehyde dehydrogenase X, mitochondrial precursor, putative |
Schistosoma mansoni | Smp_022960 | aldehyde dehydrogenase |
Schistosoma mansoni | Smp_050390 | aldehyde dehydrogenase |
Schmidtea mediterranea | mk4.000152.00 | |
Schmidtea mediterranea | mk4.040550.01 | |
Schmidtea mediterranea | mk4.004393.00 | Aldehyde dehydrogenase,putative |
Toxoplasma gondii | TGME49_222160 | aldehyde dehydrogenase |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
mtu462 | Mycobacterium tuberculosis | non-essential | nmpdr |
b1300 | Escherichia coli | non-essential | goodall |
b3588 | Escherichia coli | non-essential | goodall |
TGME49_222160 | Toxoplasma gondii | Essentiality uncertain | sidik |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
Species | Known druggable target | Linked compounds | Reference |
---|---|---|---|
Rattus norvegicus | Aldehyde dehydrogenase 1A1 | Compounds | References |
Homo sapiens | aldehyde dehydrogenase 2 family (mitochondrial) | Compounds | References |
Rattus norvegicus | Aldehyde dehydrogenase, cytosolic 1 | Compounds | References |
Rattus norvegicus | Aldehyde dehydrogenase | Compounds | References |
Homo sapiens | aldehyde dehydrogenase 1 family, member A1 | Compounds | References |