Detailed view for Rv2130c

Basic information

TDR Targets ID: 6539
Mycobacterium tuberculosis, Cysteine:1D-myo-inosityl 2-amino-2-deoxy--D-glucopyranoside ligase MshC
Source Database / ID:  Tuberculist 

pI: 5.1656 | Length (AA): 414 | MW (Da): 45595 | Paralog Number: 0

Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF01406   tRNA synthetases class I (C) catalytic domain

Gene Ontology

Mouse over links to read term descriptions.
GO:0035446   GO:cysteine-glucosaminylinositol ligase activity  

GO:0010125   mycothiol biosynthetic process  
GO:0005737   cytoplasm  
GO:0005524   ATP binding  
GO:0004817   cysteine-tRNA ligase activity  
GO:0004812   aminoacyl-tRNA ligase activity  
GO:0000166   nucleotide binding  
GO:0006423   cysteinyl-tRNA aminoacylation  
GO:0006418   tRNA aminoacylation for protein translation  
GO:0006412   translation  

Structural information

Modbase 3D models:

There is 1 model calculated for this protein. More info on this model, including the model itself is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
1 414 3c8z (A) 1 412 79.00 0 1 1.9871 -1.36

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

PDB tag
  • 3C8Z:
  • Resolution Method # Atoms # Residues Dep. Date Pub. Date Mod. Date

Expression

Upregulation Percent Ranking Stage Dataset
Lower 20-40% percentile Dormant phase. murphy
Upregulation Percent Ranking Stage Dataset
Lower 0-20% percentile Dormant phase. hasan
Show/Hide expression data references
  • hasan Prioritizing genomic drug targets in pathogens: application to Mycobacterium tuberculosis.
  • murphy Identification of gene targets against dormant phase Mycobacterium tuberculosis infections.

Orthologs

Ortholog group members (OG5_237682)

Species Accession Gene Product
Mycobacterium leprae ML1302   Probable cysteine:1D-myo-inosityl 2-amino-2-deoxy--D-glucopyranoside ligase MshC
Mycobacterium tuberculosis Rv2130c   Cysteine:1D-myo-inosityl 2-amino-2-deoxy--D-glucopyranoside ligase MshC
Mycobacterium ulcerans MUL_2360   cysteinyl-tRNA synthetase

Essentiality

Rv2130c has direct evidence of essentiality
Gene/Ortholog Organism Phenotype Source Study
mtu2163 this record Mycobacterium tuberculosis essential nmpdr
Show/Hide essentiality data references
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan

Phenotypes and Validation (curated)

Annotated phenotypes:

Affected Entity Phenotypic quality Occurs in Occurs at Evidence Observed in Drugs/Inhibitors
response to drug (GO:0042493) increased sensitivity toward (PATO:0001549) inferred from loss-of-function mutant phenotype (ECO:0000016) Mycobacterium tuberculosis 322370   347521   561927   570798  
Annotator: crowther@u.washington.edu. Comment: 2007-12-27. References: 15342574
catalytic activity (GO:0003824) decreased (PATO:0000468) in vitro (MI:0492) inferred from specific protein inhibition (ECO:0000020) Mycobacterium tuberculosis No drug identifiers listed for this gene.
Annotator: crowther@u.washington.edu. Comment: 2007-12-26. References: 12384335
response to drug (GO:0042493) increased sensitivity toward (PATO:0001549) inferred from loss-of-function mutant phenotype (ECO:0000016) Mycobacterium tuberculosis 3489   11947   12164   26407   66670   73943   89043   169308   205696   378526   403368   410797   443550   533519   533741   543733   543734   543735   546574   547173   578377   579021  
Annotator: crowther@u.washington.edu. Comment: 2007-12-26. References: 12384335
response to drug (GO:0042493) decreased sensitivity toward (PATO:0001550) inferred from gain-of-function mutant phenotype (ECO:0000042) Mycobacterium tuberculosis 5089   216208  
Annotator: crowther@u.washington.edu. Comment: 2007-12-26. References: 12384335
growth (GO:0040007) lethal (sensu genetics) (PATO:0000718) inferred from loss-of-function mutant phenotype (ECO:0000016) Mycobacterium tuberculosis No drug identifiers listed for this gene.
Annotator: crowther@u.washington.edu. Comment: 2007-12-26. References: 14594852
catalytic activity (GO:0003824) decreased (PATO:0000468) in vitro (MI:0492) inferred from specific protein inhibition (ECO:0000020) Mycobacterium tuberculosis No drug identifiers listed for this gene.
Annotator: crowther@u.washington.edu. Comment: 2007-12-27. References: 16674910
growth (GO:0040007) decreased (PATO:0000468) inferred from in vitro culture assay (ECO:0000182) Mycobacterium smegmatis No drug identifiers listed for this gene.
Annotator: crowther@u.washington.edu. Comment: 2007-12-27. References: 16674910

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

Compound Source Reference
Curated by TDRTargets References
ChEMBL23 References
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Curated by TDRTargets References
Curated by TDRTargets References
Curated by TDRTargets References
Curated by TDRTargets References
Curated by TDRTargets References
Curated by TDRTargets References
Curated by TDRTargets References
Curated by TDRTargets References
Curated by TDRTargets References
Curated by TDRTargets References
Curated by TDRTargets References
Curated by TDRTargets References
Curated by TDRTargets References
Curated by TDRTargets References
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Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Mycobacterium leprae Probable cysteine:1D-myo-inosityl 2-amino-2-deoxy--D-glucopyranoside ligase MshC Compounds References
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model

Ranking Plot

Putative Drugs List

Compound Raw Global Species
0.6025 1 1
0.2208 0.9666 1
0.208 1 1
0.3296 1 1
0.2655 1 1
0.6017 1 1
0.6001 1 1
0.2523 0.803 1
0.6047 0.8871 0.8871
0.283 1 1
0.5919 1 1
0.2993 1 1
0.6593 0.4762 1
0.2752 1 1
0.5919 0.3836 1
0.179 0.8365 1
0.5498 0.4218 1
0.7232 0.4696 0.4695
0.602 1 1
0.5915 1 1
0.8178 1 1
0.288 1 1
0.8651 1 1
0.1903 1 1
0.5112 0.2891 0.4056
0.5947 1 1
0.551 1 1
0.2637 1 1
0.6506 1 1
0.133 0.8117 1
1.1662 1 1
0.5889 1 1
0.2941 1 1
0.2926 1 1
0.5408 1 1
0.5617 1 1
0.6017 1 1
0.6001 1 1
0.2661 1 1
0.3046 1 1
0.2894 1 1
0.7121 1 1
0.5967 1 1
0.5395 1 1
0.8005 0.912 1
0.179 0.8365 1
0.5713 1 1
0.8577 1 1
0.2993 1 1
0.6702 0.2894 0.45
0.5788 1 1
0.5741 0.3804 1
0.2682 1 1
0.2523 0.803 1
0.2889 1 1
0.587 0.4751 1
0.128 0.3545 1
0.5739 0.3599 0.969
0.6278 1 1
0.5919 0.3836 1
0.2857 0.307 1
0.601 1 1
0.5592 1 1
0.9253 1 1
0.761 0.4698 0.4697
0.5868 1 1
0.631 1 1
0.2222 1 1
0.6002 1 1
0.0483 0.6457 1
0.6593 0.4762 1
0.5805 0.5331 1
0.555 1 1
0.6212 1 1
0.5498 0.4218 1
0.3642 1 1
0.6593 0.4762 1
0.6066 1 1
0.3296 0.7612 1
0.2702 0.5212 0.5708
0.3173 1 1
0.1691 0.325 1
0.1565 0.9529 1
0.5642 0.3232 0.4054
0.1908 1 1
0.0287421 1 1
0.54 1 1
0.6455 1 1
0.5561 0.7171 1
0.9392 1 1
0.5528 1 1
0.6244 0.2515 1
0.3296 1 1
0.2655 0.2982 1
0.5678 1 1
0.575 1 1
0.2642 0.3715 0.6846
0.133 0.7368 0.7368
0.5993 1 1
0.587 0.5111 1
0.2935 1 1
0.554733 1 1
0.6309 1 1
0.5528 1 1
0.8325 0.7641 1
0.8757 1 1
0.529 1 1
0.05484 0.272693 0.394549
0.2657 1 1
0.5543 1 1
0.595 1 1
0.2913 1 1
0.2702 1 1
0.5566 0.4263 0.4263
0.3235 1 1
0.8903 1 1
0.8162 1 1
0.5915 1 1
0.5642 1 1
0.58 1 1
0.2889 0.8633 0.8631
0.6047 0.8871 0.8871
0.3279 1 1
0.5895 1 1
0.1545 0.997 1
0.2523 0.803 1
0.6045 1 1
0.0718 1 1
0.2171 0.981 1
0.6244 0.2515 1
0.6244 0.2515 1
0.6066 1 1
0.5642 0.468 0.4678
0.6171 0.2811 0.4406
0.312 1 1
0.5741 0.3804 1
0.5698 1 1
1.2368 1 1
0.5642 0.3233 0.4056
0.1068 0.4107 1
0.5751 1 1
0.5691 1 1
0.5915 1 1
0.2935 1 1
0.5573 1 1
0.6456 1 1
0.621 1 1
0.574 1 1
0.6069 1 1
0.5898 1 1
0.8554 0.3225 0.3225
0.5651 1 1
0.2082 1 1
0.2069 0.5041 0.504
0.0916461 0.27782 0.27782
0.5919 0.3836 1
0.2655 1 1
0.6449 1 1
0.3296 1 1
0.1094 0.3263 1
0.2639 0.3575 1
0.2112 0.3437 1
0.8298 1 1
0.6089 1 1
0.5805 0.5331 1
0.6157 1 1
0.6073 0.3525 1
0.5739 1 1
0.6627 0.4698 0.4697
0.2637 0.881 1
0.1722 0.3345 0.3418
0.123 0.7453 1
0.2839 1 1
0.2899 1 1
0.5992 1 1
0.8011 1 1
0.2959 1 1
0.5651 1 1
0.1492 1 1
0.0643 0.2689 1
0.5868 1 1
0.1974 0.5565 1
0.2665 1 1
0.5436 1 1
0.5624 1 1
0.6384 1 1
0.3447 1 1
0.3296 1 1
0.594 1 1
0.2637 0.8101 1
0.5373 1 1
0.1472 0.8766 1
0.2674 1 1
0.3235 1 1
0.5408 1 1
0.2819 0.649 1
0.5871 1 1
0.5788 1 1
0.856 1 1
0.12 0.7696 1
0.602 1 1
0.6739 0.6024 1
0.7998 0.5256 1
0.8162 1 1
0.5851 1 1
0.5999 1 1
0.2667 1 1
0.5967 1 1
0.5558 0.5241 1
0.2703 1 1
0.4582 0.2705 0.4056
0.7763 0.47 0.4698
0.5871 1 1
0.6017 1 1
0.213428 1 1
0.5713 1 1
0.2639 0.3575 1
0.6467 1 1
0.28 1 1
0.5389 1 1
0.2999 1 1
0.0554 0.7446 1
0.5678 1 1
0.9414 1 1
0.6074 1 1
0.265 1 1
0.5828 1 1
0.2678 1 1
0.594 1 1
0.6066 1 1
0.297 1 1
0.5715 1 1
0.6074 1 1
0.3306 1 1
0.3124 1 1
0.3428 1 1
0.3018 1 1
0.3046 1 1
0.6017 1 1
0.2922 1 1
0.611 1 1
0.0448 0.2513 1
0.5954 1 1
0.3296 0.4848 0.5213
1.1662 1 1
0.3296 0.7612 1
0.8651 1 1
0.5567 1 1
0.8198 0.8406 1
0.6244 0.2515 1
0.6025 1 1
0.8554 0.3225 0.3225
0.6545 1 1
0.5498 0.4218 1
0.602 1 1
0.6593 0.4762 1
0.5529 1 1
0.5899 1 1
0.312 1 1
0.2639 0.3575 1
0.6157 1 1
0.8673 1 1
0.5558 0.5241 1
0.0452 0.6457 1
0.3447 1 1
0.5967 1 1
0.579 0.3687 1
0.2657 1 1
0.3296 0.7612 1
0.5937 1 1
0.2171 0.3641 0.5184
0.833 0.6333 1
0.579 1 1
0.3296 1 1
0.6505 1 1
0.5981 0.8603 1
0.6017 1 1
0.8651 1 1
0.6481 1 1
0.8651 1 1
0.332 1 1
0.3296 0.7612 1
0.6017 1 1
0.548 1 1
0.3127 1 1
0.6047 0.8871 0.8871
0.189 0.6901 1
0.7763 0.47 0.4697
0.2709 1 1
0.5307 1 1
0.3296 0.4024 1
0.6008 1 1
0.6593 0.4762 1
0.2764 0.3203 1
0.3296 0.7612 1
0.3472 1 1
0.0581 0.2636 1
0.3018 1 1
0.2922 1 1
0.5741 0.3804 1
0.1343 1 1
0.5741 0.3804 1
0.6102 1 1
0.1562 0.2742 0.2742
0.9457 1 1
0.5573 1 1
0.5919 1 1
0.4582 0.2705 0.4056
0.587 0.4751 1
0.5461 1 1
0.78 1 1
0.3296 0.4805 0.4802
0.57 1 1
0.5739 0.3599 0.969
0.0665 1 1
0.5882 1 1
0.3018 1 1
0.5802 0.3699 1
0.6074 1 1
0.312 1 1
0.2727 1 1
0.2639 1 1
0.2926 1 1
0.6244 1 1
0.5981 0.8603 1
0.5954 1 1
0.6154 1 1
0.6357 1 1
0.5993 1 1
0.0448 0.2515 1
0.5992 1 1
0.6278 1 1
0.264 1 1
0.3296 0.3473 1
0.2846 1 1
0.6545 1 1
0.5967 1 1
0.591 1 1
0.3092 1 1
0.2784 1 1
0.85 1 1
0.6481 1 1
0.5318 1 1
0.5558 0.5241 1
0.2674 1 1
0.611 1 1
0.6045 1 1
0.5805 0.5331 1
0.5562 1 1
0.3223 1 1
0.9185 1 1
0.2667 1 1
0.618659 1 1
0.5811 1 1
0.2889 1 1
0.9349 1 1
0.5757 1 1
0.3263 0.5 0.5
0.312 1 1
0.579 0.3687 1
0.2959 1 1
0.2889 1 1
0.5919 0.3836 1
0.2935 1 1
0.5383 1 1
0.2702 0.5212 0.5708
0.2523 0.803 1
0.2857 1 1
0.5919 1 1
0.2678 1 1
0.8216 1 1
0.5993 1 1
0.5498 0.4218 1
0.2678 1 1
0.6102 1 1
0.2959 1 1
0.5981 1 1
0.2752 1 1
0.2657 1 1
0.8148 1 1
0.568 1 1
0.1976 1 1
0.3296 1 1
0.2655 1 1
0.3296 0.3473 1
0.621 1 1
0.5596 1 0.5
0.2642 0.3715 0.6846
0.2222 1 1
0.6216 1 1
0.6001 1 1
0.3018 1 1
0.5466 1 1
0.6515 0.738 1
0.8056 1 1
0.555 1 1
0.5802 0.3699 1
0.3018 1 1
0.2843 1 1
0.7232 0.4696 0.4695
0.6244 0.2515 1
0.9051 1 1
0.2444 1 1
0.3296 0.4848 0.5213
0.3296 0.7612 1
0.5605 1 1
0.8922 1 1
0.2727 1 1
0.6073 0.3525 1
0.602 1 1
0.208 1 1
0.6069 1 1
0.5859 1 1
0.5981 0.8603 1
0.7232 0.4696 0.4695
0.5802 0.3699 1
0.1352 0.7719 1
0.636 1 1
0.0597 1 1
0.7969 1 1
0.5941 1 1
0.5975 1 1
0.579 0.3687 1
0.6011 1 1
0.7577 1 1
0.189 0.9207 1
0.1107 0.5716 1
0.7953 1 1
0.6515 0.7383 1
0.3296 0.797 1
0.2857 0.307 1
0.5351 1 1
0.8073 1 1
0.2747 1 1
0.5751 1 1
0.611 1 1
0.5307 1 1
0.8177 1 1
0.2655 0.2982 1
0.8986 0.7108 1
0.587 0.4751 1
0.5312 1 1
0.7232 0.4696 0.4695
0.6047 0.8871 0.8871
0.5715 1 1
0.5466 1 1
0.2959 1 1
0.2678 1 1
0.2889 0.8633 0.8631
0.193 0.3818 1
0.5878 1 1
0.8651 1 1
0.5529 1 1
0.5498 0.4218 1
0.2778 1 1
0.1466 0.6763 1
0.1306 1 1
0.6313 1 1
0.6074 0.8462 1
0.631 1 1
0.2999 1 1
0.3018 1 1
0.3296 0.4848 0.5213
0.2922 0.2689 1
0.6171 0.281 0.4405
0.6301 1 1
0.2523 0.4353 0.8218
0.8325 0.7641 1
0.2674 1 1
0.8673 1 1
0.1322 1 1
0.3296 0.4024 1
0.8056 1 1
0.5993 1 1
0.7943 0.4422 1
0.5919 1 1
0.2523 0.803 1
0.1107 0.5716 1
0.6408 1 1
0.2965 1 1
0.0743 1 1
0.2727 1 1
0.621 1 1
0.2922 0.8321 1
0.6088 1 1
0.5651 1 1
0.2922 0.2689 1
0.6481 1 1
0.6171 0.281 0.4405
0.5981 0.8603 1
0.8554 0.3225 0.3225
0.2583 0.6834 1
0.2993 1 1
0.3296 0.4848 0.5213
0.5875 1 1
0.2715 1 1
0.6002 1 1
0.5927 1 1
0.5019 1 1
0.3296 0.7629 0.9812
0.6066 0.7016 1
0.1313 0.403 1
0.2523 0.803 1
0.2644 1 1
0.2926 1 1
0.5696 1 1
0.3296 0.3332 1
0.2222 0.2971 1
0.2374 1 1
0.5408 1 1
0.6017 1 1
0.6047 0.8871 0.8871
0.4544 0.2693 0.2693
0.6506 1 1
0.8005 1 1
0.581 1 1
0.5691 1 1
0.135 1 1
0.3061 0.9897 1
0.5617 1 1
0.5739 0.3599 0.969
0.5642 0.468 0.4678
0.6066 1 1
0.6034 1 1
0.1243 1 1
0.5691 1 1
0.6301 1 1
0.1421 0.5528 0.5528
0.2673 1 1
0.8011 1 1
0.587 0.4751 1
0.5582 1 1
0.5436 1 1
0.6456 1 1
0.2999 1 1
0.5751 1 1
0.3296 0.4848 0.5213
0.4765 1 1
0.5408 1 1
0.3296 0.4848 0.5213
0.1406 0.5267 0.5258
0.0483 0.6457 1
0.2999 1 1
0.1213 1 1
0.3296 0.4848 0.5213
0.2912 1 1
0.1974 0.5565 1
0.3296 0.4848 0.5213
0.3061 0.9897 1
0.2922 0.8321 1
0.6047 0.8871 0.8871
0.8903 1 1
0.3296 0.3473 1
0.6068 1 1
0.5791 1 1
0.5713 1 1
0.6593 1 1
0.2727 1 1
0.1259 0.6575 1
0.2993 1 1
0.5566 0.4261 0.426
0.601 1 1
0.265 1 1
0.5651 1 1
0.6047 1 1
0.611 1 1
0.5889 1 1
0.5919 0.3836 1
0.6336 1 1
0.8056 1 1
0.1438 0.3204 0.3194
0.2655 0.2982 1
0.312 1 1
0.8922 1 1
0.1509 0.4552 0.4552
0.3235 1 1
0.8382 1 1
0.5878 1 1
0.3064 1 1
0.5868 1 1
0.5889 1 1
0.6341 1 1
0.5464 0.4237 1
0.5683 1 1
0.2941 1 1
0.8109 1 1
0.8109 1 1
0.268 1 1
0.3028 1 1
0.8095 1 1
0.139 0.7663 0.7663
0.1492 1 1
0.312 1 1
0.6129 1 1
0.5889 1 1
0.5915 1 1
0.5775 1 1
0.6417 1 1
0.5706 1 1
0.2899 1 1
0.2941 1 1
0.9464 1 1
0.5739 1 1
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0.630168 0.260801 0.26067
0.2702 1 1
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0.6073 0.3525 1
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0.0601 0.2626 0.3793
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0.3443 0.6794 0.6793
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0.3296 0.4024 1
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0.1903 0.6141 0.6141
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0.055 1 1
0.5036 0.4262 0.426
0.0536916 1 1
0.54 1 1
0.8651 1 1
0.2175 1 1
0.1249 1 1
0.2922 1 1
0.5878 1 1
0.9414 1 1
0.5691 1 1
0.2857 0.307 1
0.8673 1 1
0.3296 0.4848 0.5213
0.2655 1 1
0.312 1 1
0.6157 1 1
0.587 0.4751 1
0.3296 0.4848 0.5213
0.5482 1 1

Assayability

Assay information

  • ChEMBL
  • Binding affinity to Mycobacterium tuberculosis recombinant MBP-tagged MshC by STD-NMR analysis
  • ChEMBL
  • Inhibition of Mycobacterium tuberculosis recombinant MBP-tagged MshC assessed as formation of fluorescently labeled Cys-GlcN-Ins by HPLC
  • ChEMBL
  • Binding affinity to Mycobacterium tuberculosis recombinant MBP-tagged MshC by isothermal titration calorimetry assay
  • ChEMBL
  • Inhibition of Mycobacterium tuberculosis recombinant MshC assessed as production of Cys-GlcN-Ins from cysteine by HPLC based fluorescence assay
  • BRENDA Assay
  • An enzyme with this EC number or name or sequence has been assayed in Mycobacterium smegmatis ( 1 )

Reagent availability

  • Reagent:
  • Target Type Source Notes
    Rv2130c cloned gene BRENDA A gene with this EC number or name or sequence has been cloned from Mycobacterium smegmatis ( 1 )

Bibliographic References

4 literature references were collected for this gene.

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Gene identifier Rv2130c (Mycobacterium tuberculosis), Cysteine:1D-myo-inosityl 2-amino-2-deoxy--D-glucopyranoside ligase MshC
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