pI: 4.7459 |
Length (AA): 565 |
MW (Da): 64306 |
Paralog Number:
1
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
PDB Structures:
Ortholog group members (OG5_128147)
Species | Accession | Gene Product |
---|---|---|
Brugia malayi | Bm1_24015 | ribosomal protein S6 kinase alpha 3 |
Candida albicans | CaO19.13654 | Serine/threonine protein kinase |
Candida albicans | CaO19.6275 | Serine/threonine protein kinase |
Caenorhabditis elegans | CELE_T01H8.1 | Protein RSKN-1, isoform D |
Dictyostelium discoideum | DDB_G0277449 | SGK family protein kinase |
Drosophila melanogaster | Dmel_CG17596 | Ribosomal protein S6 kinase II |
Echinococcus granulosus | EgrG_000641400 | ribosomal protein S6 kinase alpha 3 |
Echinococcus multilocularis | EmuJ_000641400 | ribosomal protein S6 kinase alpha 3 |
Giardia lamblia | GL50803_11364 | Kinase, AGC AKT |
Homo sapiens | ENSG00000072133 | ribosomal protein S6 kinase, 90kDa, polypeptide 6 |
Homo sapiens | ENSG00000117676 | ribosomal protein S6 kinase, 90kDa, polypeptide 1 |
Homo sapiens | ENSG00000071242 | ribosomal protein S6 kinase, 90kDa, polypeptide 2 |
Homo sapiens | ENSG00000177189 | ribosomal protein S6 kinase, 90kDa, polypeptide 3 |
Leishmania braziliensis | LbrM.30.0920 | rac serine-threonine kinase, putative,protein kinase, putative |
Leishmania donovani | LdBPK_300850.1 | rac serine-threonine kinase, putative |
Leishmania infantum | LinJ.30.0850 | rac serine-threonine kinase, putative,protein kinase, putative |
Leishmania major | LmjF.30.0800 | rac serine-threonine kinase, putative,protein kinase, putative |
Leishmania mexicana | LmxM.29.0800 | rac serine-threonine kinase, putative,protein kinase, putative |
Loa Loa (eye worm) | LOAG_01357 | AGC/RSK/RSK protein kinase |
Mus musculus | ENSMUSG00000023809 | ribosomal protein S6 kinase, polypeptide 2 |
Mus musculus | ENSMUSG00000025665 | ribosomal protein S6 kinase polypeptide 6 |
Mus musculus | ENSMUSG00000031309 | ribosomal protein S6 kinase polypeptide 3 |
Mus musculus | ENSMUSG00000003644 | ribosomal protein S6 kinase polypeptide 1 |
Saccharomyces cerevisiae | YBR028C | Ypk3p |
Schistosoma japonicum | Sjp_0216210 | Ribosomal protein S6 kinase alpha-2, putative |
Schistosoma japonicum | Sjp_0106250 | IPR000719,Protein kinase,domain-containing |
Schistosoma japonicum | Sjp_0129060 | IPR000719,Protein kinase;IPR011009,Protein kinase-like,domain-containing |
Schistosoma mansoni | Smp_017900 | serine/threonine protein kinase |
Schmidtea mediterranea | mk4.003305.00 | |
Schmidtea mediterranea | mk4.001465.05 | |
Schmidtea mediterranea | mk4.006921.00 | Putative ribosomal protein S6 kinase alpha-1 |
Schmidtea mediterranea | mk4.000379.06 |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
Species | Known druggable target | Linked compounds | Reference |
---|---|---|---|
Mus musculus | ribosomal protein S6 kinase polypeptide 3 | Compounds | References |
Homo sapiens | ribosomal protein S6 kinase, 90kDa, polypeptide 2 | Compounds | References |
Homo sapiens | ribosomal protein S6 kinase, 90kDa, polypeptide 1 | Compounds | References |
Homo sapiens | ribosomal protein S6 kinase, 90kDa, polypeptide 6 | Compounds | References |
Mus musculus | ribosomal protein S6 kinase, polypeptide 2 | Compounds | References |
Homo sapiens | ribosomal protein S6 kinase, 90kDa, polypeptide 3 | Compounds | References |
Species | Target | Length | Identity | Alignment span | Linked Drugs | Reference |
---|---|---|---|---|---|---|
Plasmodium falciparum (isolate 3D7) | Cell division control protein 2 homolog | 288 aa | 28.5% | 235 aa | Compounds | References |
Rattus norvegicus | cAMP-dependent protein kinase alpha-catalytic subunit | 351 aa | 39.1% | 299 aa | Compounds | References |
Oryctolagus cuniculus | cAMP-dependent protein kinase alpha-catalytic subunit | 351 aa | 37.5% | 299 aa | Compounds | References |
Bos taurus | cAMP-dependent protein kinase alpha-catalytic subunit | 351 aa | 39.9% | 298 aa | Compounds | References |
Rattus norvegicus | Cell division protein kinase 5 | 292 aa | 25.2% | 309 aa | Compounds | References |
Patiria pectinifera | Cdc2 | 300 aa | 29.0% | 241 aa | Compounds | References |
Oryctolagus cuniculus | Cyclin-dependent kinase 4 | 189 aa | 31.4% | 159 aa | Compounds | References |
Xenopus laevis | Aurora kinase B-B | 368 aa | 29.2% | 343 aa | Compounds | References |