pI: 9.7269 |
Length (AA): 1153 |
MW (Da): 128885 |
Paralog Number:
1
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 2 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
151 | 698 | 3uzs (A) | 95 | 665 | 17.00 | 0 | 1 | 0.469182 | 0.97 |
233 | 523 | 4c0t (A) | 233 | 523 | 99.00 | 0 | 1 | 1.46739 | -1.42 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Ortholog group members (OG5_128785)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT3G10540 | 3-phosphoinositide-dependent protein kinase |
Arabidopsis thaliana | AT5G04510 | 3'-phosphoinositide-dependent protein kinase 1 |
Brugia malayi | Bm1_30965 | Protein kinase domain containing protein |
Brugia malayi | Bm1_28150 | phosphoinositide-dependent protein kinase I |
Candida albicans | CaO19.5224 | similar to S. cerevisiae protein kinases PKH1 (YDR490C) and PKH2 (YOL100W) involved in MAPKKK cascade |
Candida albicans | CaO19.12690 | similar to S. cerevisiae protein kinases PKH1 (YDR490C) and PKH2 (YOL100W) involved in MAPKKK cascade |
Caenorhabditis elegans | CELE_H42K12.1 | Protein PDK-1, isoform B |
Caenorhabditis elegans | CELE_W04B5.5 | Protein W04B5.5 |
Dictyostelium discoideum | DDB_G0284489 | PDK1 family protein kinase |
Dictyostelium discoideum | DDB_G0277145 | PKA family protein kinase |
Drosophila melanogaster | Dmel_CG1210 | Phosphoinositide-dependent kinase 1 |
Echinococcus granulosus | EgrG_000723900 | 3-phosphoinositide-dependent protein kinase 1 |
Entamoeba histolytica | EHI_095940 | protein kinase, putative |
Echinococcus multilocularis | EmuJ_000723900 | 3 phosphoinositide dependent protein kinase 1 |
Homo sapiens | 101060747 | 3-phosphoinositide-dependent protein kinase 1-like |
Homo sapiens | ENSG00000140992 | 3-phosphoinositide dependent protein kinase 1 |
Loa Loa (eye worm) | LOAG_09248 | AGC/PDK1 protein kinase |
Loa Loa (eye worm) | LOAG_03280 | AGC/PDK1 protein kinase |
Mus musculus | ENSMUSG00000024122 | 3-phosphoinositide dependent protein kinase 1 |
Oryza sativa | 4324953 | Os01g0872800 |
Saccharomyces cerevisiae | YDR490C | Pkh1p |
Saccharomyces cerevisiae | YOL100W | Pkh2p |
Schistosoma japonicum | Sjp_0035230 | ko:K06276 3-phosphoinositide dependent protein kinase-1, putative |
Schistosoma mansoni | Smp_094250 | serine/threonine protein kinase |
Schmidtea mediterranea | mk4.007072.00 | 3-phosphoinositide-dependent protein kinase 1 |
Trichomonas vaginalis | TVAG_240510 | AGC family protein kinase |
Trichomonas vaginalis | TVAG_366130 | AGC family protein kinase |
Trichomonas vaginalis | TVAG_035920 | AGC family protein kinase |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
CELE_W04B5.5 | Caenorhabditis elegans | embryonic lethal | wormbase |
CELE_W04B5.5 | Caenorhabditis elegans | larval arrest | wormbase |
CELE_W04B5.5 | Caenorhabditis elegans | sterile | wormbase |
YOL100W | Saccharomyces cerevisiae | inviable | yeastgenome |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
Species | Known druggable target | Linked compounds | Reference |
---|---|---|---|
Homo sapiens | 3-phosphoinositide dependent protein kinase 1 | Compounds | References |
Species | Target | Length | Identity | Alignment span | Linked Drugs | Reference |
---|---|---|---|---|---|---|
Rattus norvegicus | Jak1 protein | 210 aa | 22.7% | 198 aa | Compounds | References |
Rattus norvegicus | Cell division protein kinase 5 | 292 aa | 24.7% | 304 aa | Compounds | References |
Rattus norvegicus | MAP kinase p38 alpha | 360 aa | 26.2% | 324 aa | Compounds | References |
Plasmodium falciparum (isolate 3D7) | Cell division control protein 2 homolog | 288 aa | 25.5% | 294 aa | Compounds | References |
Rattus norvegicus | Serine/threonine-protein kinase pim-3 | 326 aa | 28.2% | 273 aa | Compounds | References |
Patiria pectinifera | Cdc2 | 300 aa | 27.2% | 309 aa | Compounds | References |
Sus scrofa | Casein kinase I isoform alpha | 125 aa | 25.8% | 132 aa | Compounds | References |