Detailed view for CaO19.1446

Basic information

TDR Targets ID: 656769
Candida albicans, likely G2 B-type cyclin similar to S. cerevisiae CLB1 (YPR119W) which is involved in mitotic induction
Source Database / ID:  KEGG  

pI: 6.2608 | Length (AA): 492 | MW (Da): 56799 | Paralog Number: 3

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00134   Cyclin, N-terminal domain
PF02984   Cyclin, C-terminal domain

Gene Ontology

Mouse over links to read term descriptions.
GO:0005634   nucleus  

Metabolic Pathways

Cell cycle - yeast (KEGG)

Structural information

Modbase 3D models:

There are 6 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
2 187 4kf7 (A) 260 445 9.00 0 0.01 0.496249 -0.69
24 170 3cvr (A) 48 210 28.00 0.89 0.06 0.50638 -0.19
202 449 2cch (B) 175 424 35.00 0 1 0.976665 -0.6
203 449 3qhw (B) 176 424 32.00 0.00000012 1 0.982933 -0.92
203 466 1w98 (B) 95 353 26.00 0.034 1 0.801485 -0.26
203 449 5lqf (B) 168 415 39.00 0 1 1.00663 -0.82

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_126649)

Species Accession Gene Product
Arabidopsis thaliana AT5G25380   1
Arabidopsis thaliana AT1G20610   3
Arabidopsis thaliana AT1G47230   4
Arabidopsis thaliana AT1G44110   1
Arabidopsis thaliana AT1G47220   3
Arabidopsis thaliana AT1G47210   2
Arabidopsis thaliana AT5G43080   1
Arabidopsis thaliana AT1G76310   4
Arabidopsis thaliana AT4G37490   1
Arabidopsis thaliana AT5G06150   cyclin-B1-2
Arabidopsis thaliana AT5G11300   cyclin-A2-2
Arabidopsis thaliana AT4G35620   2
Arabidopsis thaliana AT2G17620   1
Arabidopsis thaliana AT3G11520   3
Arabidopsis thaliana AT1G34460   5
Brugia malayi Bm1_27665   Cyclin, N-terminal domain containing protein
Brugia malayi Bm1_12035   Cyclin, N-terminal domain containing protein
Candida albicans CaO19.9021   likely G2 B-type cyclin similar to S. cerevisiae CLB1 (YPR119W) which is involved in mitotic induction
Candida albicans CaO19.7186   likely B-type cyclin similar to S. cerevisiae CLB4 (YLR210W) and CLB3 (YDL155W) involved in G1/S transition
Candida albicans CaO19.1446   likely G2 B-type cyclin similar to S. cerevisiae CLB1 (YPR119W) which is involved in mitotic induction
Candida albicans CaO19_7186   hypothetical protein
Caenorhabditis elegans CELE_ZK507.6   Protein CYA-1
Caenorhabditis elegans CELE_ZC168.4   Protein CYB-1
Caenorhabditis elegans CELE_Y43E12A.1   Protein CYB-2.1
Caenorhabditis elegans CELE_H31G24.4   Protein CYB-2.2
Cryptosporidium hominis Chro.30456   mitotic cyclin-CYC2
Cryptosporidium parvum cgd3_4050   cyclin
Dictyostelium discoideum DDB_G0275493   G2/M-specific cyclinB
Drosophila melanogaster Dmel_CG5940   Cyclin A
Drosophila melanogaster Dmel_CG3510   Cyclin B
Echinococcus granulosus EgrG_001070150   cyclin B
Entamoeba histolytica EHI_030880   cyclin, putative
Echinococcus multilocularis EmuJ_001070150   cyclin B
Giardia lamblia GL50803_3977   G2/mitotic-specific cyclin B
Homo sapiens ENSG00000133101   cyclin A1
Homo sapiens ENSG00000134057   cyclin B1
Homo sapiens ENSG00000145386   cyclin A2
Homo sapiens ENSG00000157456   cyclin B2
Leishmania braziliensis LbrM.32.3610   CYC2-like cyclin, putative,cyclin 6, putative
Leishmania braziliensis LbrM.25.1330   cyclin
Leishmania donovani LdBPK_323520.1   CYC2-like cyclin, putative
Leishmania donovani LdBPK_251530.1   cyclin
Leishmania infantum LinJ.25.1530   cyclin
Leishmania infantum LinJ.32.3520   CYC2-like cyclin, putative,cyclin 6, putative
Leishmania major LmjF.25.1470   cyclin
Leishmania major LmjF.32.3320   CYC2-like cyclin, putative,cyclin 6, putative
Leishmania mexicana LmxM.31.3320   CYC2-like cyclin, putative,cyclin 6, putative
Leishmania mexicana LmxM.25.1470   cyclin
Loa Loa (eye worm) LOAG_13943   hypothetical protein
Loa Loa (eye worm) LOAG_08137   hypothetical protein
Loa Loa (eye worm) LOAG_07984   hypothetical protein
Mus musculus ENSMUSG00000032218   cyclin B2
Mus musculus 434175   predicted gene 5593
Mus musculus 102643276   G2/mitotic-specific cyclin-B1-like
Mus musculus ENSMUSG00000041431   cyclin B1
Mus musculus ENSMUSG00000027715   cyclin A2
Mus musculus ENSMUSG00000027793   cyclin A1
Oryza sativa 4352642   Os12g0581800
Oryza sativa 4333422   Os03g0607600
Oryza sativa 9268829   Os12g0298950
Oryza sativa 4339185   Os05g0493500
Oryza sativa 4336670   Os04g0563700
Oryza sativa 4324288   Os01g0233500
Oryza sativa 4327547   Os01g0805600
Oryza sativa 4326914   Os01g0281200
Oryza sativa 9268872   Os05g0501350
Oryza sativa 4342121   Os06g0726800
Onchocerca volvulus OVOC12051  
Saccharomyces cerevisiae YLR210W   Clb4p
Saccharomyces cerevisiae YPR119W   Clb2p
Saccharomyces cerevisiae YGR108W   Clb1p
Saccharomyces cerevisiae YDL155W   Clb3p
Saccharomyces cerevisiae YGR109C   Clb6p
Schistosoma japonicum Sjp_0035030   ko:K05868 cyclin B, putative
Schistosoma mansoni Smp_082490   cyclin B
Schmidtea mediterranea mk4.013209.00   CyclinB-like protein
Schmidtea mediterranea mk4.000226.04   Cyclin B-1
Schmidtea mediterranea mk4.000312.15   CyclinE-like protein
Schmidtea mediterranea mk4.000679.02  
Trypanosoma brucei gambiense Tbg972.11.18860   cyclin 6,mitotic cyclin
Trypanosoma brucei Tb927.11.16720   mitotic cyclin 6
Trypanosoma congolense TcIL3000.11.16610   mitotic cyclin 6
Trypanosoma congolense TcIL3000_3_270   Cyclin, N-terminal domain/Cyclin, C-terminal domain containing protein, putative
Trypanosoma cruzi TcCLB.506711.30   cyclin, putative
Trypanosoma cruzi TcCLB.507089.260   CYC2-like cyclin, putative
Trypanosoma cruzi TcCLB.509455.140   cyclin, putative
Trypanosoma cruzi TcCLB.511025.120   cyclin 6, putative
Trichomonas vaginalis TVAG_335410   cyclins, putative
Trichomonas vaginalis TVAG_494460   cyclins, putative
Trichomonas vaginalis TVAG_486130   cyclins, putative
Trichomonas vaginalis TVAG_371670   cyclins, putative
Trichomonas vaginalis TVAG_187920   cyclin B, putative
Trichomonas vaginalis TVAG_488140   cyclins, putative
Trichomonas vaginalis TVAG_266050   cyclin B, putative
Trichomonas vaginalis TVAG_309310   cyclin A, putative
Trichomonas vaginalis TVAG_468150   cyclin B, putative
Trichomonas vaginalis TVAG_121680   cyclin B, putative

Essentiality

CaO19.1446 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
Tb11.01.8460 Trypanosoma brucei significant loss of fitness in bloodstream forms (3 days) alsford
Tb11.01.8460 Trypanosoma brucei significant loss of fitness in bloodstream forms (6 days) alsford
Tb11.01.8460 Trypanosoma brucei significant loss of fitness in procyclic forms alsford
Tb11.01.8460 Trypanosoma brucei significant loss of fitness in differentiation of procyclic to bloodstream forms alsford
CELE_ZK507.6 Caenorhabditis elegans embryonic lethal wormbase
CELE_ZC168.4 Caenorhabditis elegans embryonic lethal wormbase
CELE_ZC168.4 Caenorhabditis elegans larval arrest wormbase
CELE_Y43E12A.1 Caenorhabditis elegans embryonic lethal wormbase
CELE_Y43E12A.1 Caenorhabditis elegans larval arrest wormbase
CELE_H31G24.4 Caenorhabditis elegans embryonic lethal wormbase
CELE_H31G24.4 Caenorhabditis elegans larval arrest wormbase
YDL155W Saccharomyces cerevisiae inviable yeastgenome
Show/Hide essentiality data references
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Rattus norvegicus G2/mitotic-specific cyclin B1 Compounds References
Homo sapiens cyclin B1 Compounds References
Homo sapiens cyclin A1 Compounds References
Asterina pectinifera G2/mitotic-specific cyclin-B Compounds References
Homo sapiens cyclin B2 Compounds References
Homo sapiens cyclin A2 Compounds References
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

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User comments

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Gene identifier CaO19.1446 (Candida albicans), likely G2 B-type cyclin similar to S. cerevisiae CLB1 (YPR119W) which is involved in mitotic induction
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