pI: 4.613 |
Length (AA): 306 |
MW (Da): 36617 |
Paralog Number:
1
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
PDB Structures:
Ortholog group members (OG5_128459)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT3G59380 | farnesyltransferase A |
Babesia bovis | BBOV_III002550 | protein prenyltransferase alpha subunit repeat domain containing protein |
Brugia malayi | Bm1_24725 | Protein prenyltransferase alpha subunit repeat containing protein |
Candida albicans | CaO19.12280 | alpha subunit shared by C terminal CaaX Geranylgeranyltransferase I (Ram2p+Cdc43p) and farnesyltransferase (Ram2p+Ram1p) |
Candida albicans | CaO19.4817 | alpha subunit shared by C terminal CaaX Geranylgeranyltransferase I (Ram2p+Cdc43p) and farnesyltransferase (Ram2p+Ram1p) |
Caenorhabditis elegans | CELE_R02D3.5 | Protein FNTA-1 |
Cryptosporidium hominis | Chro.60290 | farnesyltransferase |
Cryptosporidium parvum | cgd6_2510 | farnesyltransferase |
Dictyostelium discoideum | DDB_G0283053 | protein farnesyltransferase/geranylgeranyltransferase type I alpha subunit |
Drosophila melanogaster | Dmel_CG2976 | CG2976 gene product from transcript CG2976-RB |
Echinococcus granulosus | EgrG_000631400 | protein farnesyltransferase alpha subunit |
Entamoeba histolytica | EHI_074760 | protein farnesyltransferase alpha subunit, putative |
Echinococcus multilocularis | EmuJ_000631400 | protein farnesyltransferase alpha subunit |
Giardia lamblia | GL50803_15820 | Rab geranylgeranyltransferase |
Homo sapiens | ENSG00000168522 | farnesyltransferase, CAAX box, alpha |
Loa Loa (eye worm) | LOAG_09512 | prenyltransferase alpha subunit repeat containing protein |
Loa Loa (eye worm) | LOAG_12157 | hypothetical protein |
Mus musculus | ENSMUSG00000015994 | farnesyltransferase, CAAX box, alpha |
Neospora caninum | NCLIV_006520 | hypothetical protein |
Oryza sativa | 4347566 | Os09g0514400 |
Plasmodium berghei | PBANKA_1456000 | protein farnesyltransferase subunit alpha, putative |
Plasmodium falciparum | PF3D7_1242600 | protein farnesyltransferase subunit alpha |
Plasmodium knowlesi | PKNH_1461900 | protein farnesyltransferase subunit alpha, putative |
Plasmodium vivax | PVX_101030 | prenyltransferase alpha subunit, putative |
Saccharomyces cerevisiae | YKL019W | bifunctional protein farnesyltransferase/protein geranylgeranyltransferase |
Schistosoma japonicum | Sjp_0120990 | ko:K05954 farnesyltransferase, CAAX box, alpha [EC:2.5.1.58 2.5.1.59], putative |
Schistosoma mansoni | Smp_091770 | protein farnesyltransferase alpha subunit |
Schmidtea mediterranea | mk4.000226.09 | |
Toxoplasma gondii | TGME49_297510 | hypothetical protein |
Theileria parva | TP03_0712 | hypothetical protein |
Trichomonas vaginalis | TVAG_257590 | protein farnesyltransferase alpha subunit, putative |
Trichomonas vaginalis | TVAG_434060 | protein farnesyltransferase alpha subunit, putative |
Trichomonas vaginalis | TVAG_230550 | protein farnesyltransferase alpha subunit/RAB geranylgeranyl transferase alpha subunit, putative |
Trichomonas vaginalis | TVAG_190520 | protein farnesyltransferase alpha subunit/RAB geranylgeranyl transferase alpha subunit, putative |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
CELE_R02D3.5 | Caenorhabditis elegans | embryonic lethal | wormbase |
CELE_R02D3.5 | Caenorhabditis elegans | larval arrest | wormbase |
CELE_R02D3.5 | Caenorhabditis elegans | larval lethal | wormbase |
CELE_R02D3.5 | Caenorhabditis elegans | sterile | wormbase |
YKL019W | Saccharomyces cerevisiae | inviable | yeastgenome |
PBANKA_1456000 | Plasmodium berghei | Essential | plasmo |
TGME49_297510 | Toxoplasma gondii | Essentiality uncertain | sidik |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
Species | Known druggable target | Linked compounds | Reference |
---|---|---|---|
Homo sapiens | farnesyltransferase, CAAX box, alpha | Compounds | References |
Mus musculus | farnesyltransferase, CAAX box, alpha | Compounds | References |
Plasmodium falciparum | protein farnesyltransferase subunit alpha | Compounds | References |
Saccharomyces cerevisiae | bifunctional protein farnesyltransferase/protein geranylgeranyltransferase | Compounds | References |
Rattus norvegicus | geranylgeranyltransferase type-I | Compounds | References |