Detailed view for CaO19.9369

Basic information

TDR Targets ID: 657075
Candida albicans, beta subunit of C terminal CaaX Geranylgeranyltransferase I (Ram2p+Cdc43p)
Source Database / ID:  KEGG  

pI: 6.4911 | Length (AA): 397 | MW (Da): 46442 | Paralog Number: 1

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00432   Prenyltransferase and squalene oxidase repeat

Gene Ontology

Mouse over links to read term descriptions.
GO:0003824   catalytic activity  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There is 1 model calculated for this protein. More info on this model, including the model itself is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
2 397 3dra (B) 2 390 99.00 0 1 2.17448 -1.78

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_129786)

Species Accession Gene Product
Arabidopsis thaliana AT2G39550   geranylgeranyl transferase type-1 subunit beta
Brugia malayi Bm1_20520   Prenyltransferase and squalene oxidase repeat family protein
Candida albicans CaO19.1803   beta subunit of C terminal CaaX Geranylgeranyltransferase I (Ram2p+Cdc43p)
Candida albicans CaO19.9369   beta subunit of C terminal CaaX Geranylgeranyltransferase I (Ram2p+Cdc43p)
Caenorhabditis elegans CELE_Y48E1B.3   Protein Y48E1B.3, isoform B
Dictyostelium discoideum DDB_G0269726   hypothetical protein
Drosophila melanogaster Dmel_CG3469   beta subunit of type I geranylgeranyl transferase
Echinococcus granulosus EgrG_001191900   geranylgeranyl transferase type I beta subunit
Entamoeba histolytica EHI_077230   geranylgeranyl transferase beta subunit
Echinococcus multilocularis EmuJ_001191900   geranylgeranyl transferase type I beta subunit
Homo sapiens ENSG00000164219   protein geranylgeranyltransferase type I, beta subunit
Loa Loa (eye worm) LOAG_08051   prenyltransferase and squalene oxidase repeat family protein
Mus musculus ENSMUSG00000024477   protein geranylgeranyltransferase type I, beta subunit
Oryza sativa 4324517   Os01g0150100
Saccharomyces cerevisiae YGL155W   protein geranylgeranyltransferase type I subunit CDC43
Schistosoma japonicum Sjp_0001950   ko:K05955 protein geranylgeranyltransferase type I, beta subunit [EC:2.5.1.59], putative
Schistosoma mansoni Smp_066960.2   geranylgeranyl transferase type I beta subunit
Schistosoma mansoni Smp_066960.1   geranylgeranyl transferase type I beta subunit
Schmidtea mediterranea mk4.001451.00   Putative geranylgeranyl transferase type I beta subunit
Trichomonas vaginalis TVAG_187660   geranylgeranyl transferase type I beta subunit, putative

Essentiality

CaO19.9369 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
CELE_Y48E1B.3 Caenorhabditis elegans embryonic lethal wormbase
CELE_Y48E1B.3 Caenorhabditis elegans larval arrest wormbase
YGL155W Saccharomyces cerevisiae inviable yeastgenome
Show/Hide essentiality data references
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Bos taurus Geranylgeranyl transferase type I Compounds References
Mus musculus protein geranylgeranyltransferase type I, beta subunit Compounds References
Homo sapiens protein geranylgeranyltransferase type I, beta subunit Compounds References
By sequence similarity to non orthologous druggable targets
Species Target Length Identity Alignment span Linked Drugs Reference
Rattus norvegicus geranylgeranyltransferase type-I 377 aa 24.1% 406 aa Compounds References
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier CaO19.9369 (Candida albicans), beta subunit of C terminal CaaX Geranylgeranyltransferase I (Ram2p+Cdc43p)
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