pI: 4.8217 |
Length (AA): 377 |
MW (Da): 42947 |
Paralog Number:
1
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
PDB Structures:
Ortholog group members (OG5_128610)
Species | Accession | Gene Product |
---|---|---|
Brugia malayi | Bm1_31785 | P38 map kinase family protein 2 |
Candida albicans | CaO19.895 | MAP kinase involved in osmoregulation |
Candida albicans | CaO19.8514 | MAP kinase involved in osmoregulation |
Caenorhabditis elegans | CELE_B0218.3 | Protein PMK-1 |
Drosophila melanogaster | Dmel_CG5475 | p38a MAP kinase |
Drosophila melanogaster | Dmel_CG7393 | p38b MAP kinase |
Echinococcus granulosus | EgrG_000145100 | mitogen activated protein kinase 11 |
Echinococcus granulosus | EgrG_000144900 | mitogen activated protein kinase 14 |
Echinococcus multilocularis | EmuJ_000145100 | mitogen activated protein kinase 11 |
Echinococcus multilocularis | EmuJ_000139200 | mitogen activated protein kinase 11 |
Echinococcus multilocularis | EmuJ_000139400 | mitogen activated protein kinase 14 |
Echinococcus multilocularis | EmuJ_000144900 | mitogen activated protein kinase 14 |
Homo sapiens | 5603 | mitogen-activated protein kinase 13 |
Homo sapiens | ENSG00000185386 | mitogen-activated protein kinase 11 |
Homo sapiens | ENSG00000112062 | mitogen-activated protein kinase 14 |
Leishmania braziliensis | LbrM.10.0620 | mitogen-activated protein kinase 3, putative,map kinase 3, putative |
Leishmania donovani | LdBPK_100540.1 | mitogen-activated protein kinase 3, putative |
Leishmania infantum | LinJ.10.0540 | mitogen-activated protein kinase 3, putative,map kinase 3, putative |
Leishmania major | LmjF.10.0490 | mitogen-activated protein kinase 3, putative,map kinase 3, putative |
Leishmania mexicana | LmxM.10.0490 | mitogen-activated protein kinase 3, putative,map kinase 3, putative |
Loa Loa (eye worm) | LOAG_06056 | CMGC/MAPK/P38 protein kinase |
Mus musculus | ENSMUSG00000053436 | mitogen-activated protein kinase 14 |
Mus musculus | ENSMUSG00000053137 | mitogen-activated protein kinase 11 |
Mus musculus | ENSMUSG00000004864 | mitogen-activated protein kinase 13 |
Saccharomyces cerevisiae | YLR113W | mitogen-activated protein kinase HOG1 |
Schistosoma japonicum | Sjp_0211950 | ko:K04441 p38 MAP kinase, putative |
Schmidtea mediterranea | mk4.016082.00 | Putative mitogen-activated protein kinase 14C |
Trypanosoma brucei gambiense | Tbg972.8.3240 | mitogen-activated protein kinase 3, putative |
Trypanosoma brucei | Tb927.8.3550 | mitogen-activated protein kinase 3, putative |
Trypanosoma congolense | TcIL3000_8_3490 | mitogen-activated protein kinase 3, putative |
Trypanosoma cruzi | TcCLB.509553.60 | mitogen-activated protein kinase 3, putative |
Trypanosoma cruzi | TcCLB.509475.10 | mitogen-activated protein kinase 3, putative |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
Tb927.8.3550 | Trypanosoma brucei | no significant loss or gain of fitness in bloodstream forms (3 days) | alsford |
Tb927.8.3550 | Trypanosoma brucei | no significant loss or gain of fitness in bloodstream forms (6 days) | alsford |
Tb927.8.3550 | Trypanosoma brucei | no significant loss or gain of fitness in procyclic forms | alsford |
Tb927.8.3550 | Trypanosoma brucei | no significant loss or gain of fitness in differentiation of procyclic to bloodstream forms | alsford |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
Species | Known druggable target | Linked compounds | Reference |
---|---|---|---|
Homo sapiens | mitogen-activated protein kinase 13 | Compounds | References |
Mus musculus | mitogen-activated protein kinase 11 | Compounds | References |
Mus musculus | mitogen-activated protein kinase 13 | Compounds | References |
Mus musculus | mitogen-activated protein kinase 14 | Compounds | References |
Rattus norvegicus | MAP kinase p38 alpha | Compounds | References |
Homo sapiens | mitogen-activated protein kinase 14 | Compounds | References |
Homo sapiens | mitogen-activated protein kinase 11 | Compounds | References |
Species | Target | Length | Identity | Alignment span | Linked Drugs | Reference |
---|---|---|---|---|---|---|
Patiria pectinifera | Cdc2 | 300 aa | 33.1% | 302 aa | Compounds | References |
Rattus norvegicus | Mitogen-activated protein kinase 1 | 358 aa | 45.8% | 345 aa | Compounds | References |
Rattus norvegicus | Cell division protein kinase 5 | 292 aa | 36.3% | 300 aa | Compounds | References |
Xenopus laevis | Aurora kinase B-A | 361 aa | 26.0% | 300 aa | Compounds | References |
Plasmodium falciparum (isolate 3D7) | Cell division control protein 2 homolog | 288 aa | 36.2% | 290 aa | Compounds | References |
Schizosaccharomyces pombe 972h- | Casein kinase II subunit alpha | 332 aa | 29.1% | 306 aa | Compounds | References |
Oryctolagus cuniculus | Cyclin-dependent kinase 4 | 189 aa | 39.8% | 186 aa | Compounds | References |
Xenopus laevis | Aurora kinase B-B | 368 aa | 26.5% | 302 aa | Compounds | References |
Homo sapiens | Cyclin-dependent kinase 1/cyclin B1 | 297 aa | 34.6% | 289 aa | Compounds | References |