Detailed view for Rv0933

Basic information

TDR Targets ID: 6942
Mycobacterium tuberculosis, Phosphate-transport ATP-binding protein ABC transporter PstB

Source Database / ID:  Tuberculist 

pI: 9.7539 | Length (AA): 276 | MW (Da): 29996 | Paralog Number: 1

Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00005   ABC transporter

Gene Ontology

Mouse over links to read term descriptions.
GO:0035435   GO:phosphate ion transmembrane transport  

GO:0015415   phosphate transmembrane-transporting ATPase activity  
GO:0016020   membrane  
GO:0005524   ATP binding  
GO:0005315   inorganic phosphate transmembrane transporter activity  
GO:0000166   nucleotide binding  
GO:0017111   nucleoside-triphosphatase activity  
GO:0016887   ATPase activity  
GO:0015114   phosphate transmembrane transporter activity  
GO:0006817   phosphate transport  
GO:0015833   peptide transport  

Metabolic Pathways

Structural information

Modbase 3D models:

There are 3 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
9 272 4mrs (A) 348 606 28.00 0 1 1.27832 -0.1
20 265 4u00 (A) 3 241 36.00 0 1 1.3968 -0.92
20 251 5x41 (A) 3 229 39.00 0 1 1.21718 0.15

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein


Upregulation Percent Ranking Stage Dataset
Lower 0-20% percentile Dormant phase, Dormant phase. hasan murphy
Show/Hide expression data references
  • hasan Prioritizing genomic drug targets in pathogens: application to Mycobacterium tuberculosis.
  • murphy Identification of gene targets against dormant phase Mycobacterium tuberculosis infections.


Ortholog group members (OG5_130152)

Species Accession Gene Product
Arabidopsis thaliana AT1G67940   ABC transporter I family member 17
Escherichia coli b3725   phosphate transporter subunit
Mycobacterium tuberculosis Rv0933   Phosphate-transport ATP-binding protein ABC transporter PstB
Mycobacterium tuberculosis Rv0820   Probable phosphate-transport ATP-binding protein ABC transporter PhoT
Mycobacterium ulcerans MUL_0440   phosphate transporter ATP-binding protein
Mycobacterium ulcerans MUL_4048   phosphate-transport ATP-binding protein ABC transporter PstB
Neospora caninum NCLIV_034280   ABC transporter, putative
Oryza sativa 4341938   Os06g0695800
Onchocerca volvulus OVOC12992  
Toxoplasma gondii TGME49_273360   ABC transporter transmembrane region domain-containing protein
Wolbachia endosymbiont of Brugia malayi Wbm0178   phosphate ABC transporter ATP-binding protein


Rv0933 has direct evidence of essentiality
Gene/Ortholog Organism Phenotype Source Study
mtu949 this record Mycobacterium tuberculosis non-essential nmpdr
b3725 Escherichia coli non-essential goodall
TGME49_273360 Toxoplasma gondii Essentiality uncertain sidik
Show/Hide essentiality data references
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • wormbase C. elegans RNAi experiments WormBase web site,, release WS170
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Druggability index (range: 0 to 1): 0.5

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets

Obtained from network model
No druggable targets predicted through repurposing network model


Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

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User comments

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Gene identifier Rv0933 (Mycobacterium tuberculosis), Phosphate-transport ATP-binding protein ABC transporter PstB
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