Detailed view for Rv0630c

Basic information

TDR Targets ID: 6987
Mycobacterium tuberculosis, Probable exonuclease V (beta chain) RecB (exodeoxyribonuclease V beta chain)(exodeoxyribonuclease V polypeptide) (chi-specific e

Source Database / ID:  Tuberculist 

pI: 6.3908 | Length (AA): 1094 | MW (Da): 118722 | Paralog Number: 0

Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00580   UvrD/REP helicase N-terminal domain
PF12705   PD-(D/E)XK nuclease superfamily
PF13361   UvrD-like helicase C-terminal domain

Gene Ontology

Mouse over links to read term descriptions.
GO:0005524   ATP binding  
GO:0004518   nuclease activity  
GO:0004003   ATP-dependent DNA helicase activity  
GO:0003677   DNA binding  
GO:0016787   hydrolase activity  
GO:0008854   exodeoxyribonuclease V activity  
GO:0006281   DNA repair  

Metabolic Pathways

Structural information

Modbase 3D models:

There are 3 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
2 1089 1w36 (B) 3 1174 27.00 0 1 1.09152 0.77
2 1086 1w36 (B) 3 1171 33.00 0 1 1.12497 0.79
59 272 5cwp (A) 8 227 28.00 0.42 1 0.541812 -1.14

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein


Upregulation Percent Ranking Stage Dataset
Mid 40-60% percentile Dormant phase, Dormant phase. hasan murphy
Show/Hide expression data references
  • murphy Identification of gene targets against dormant phase Mycobacterium tuberculosis infections.
  • hasan Prioritizing genomic drug targets in pathogens: application to Mycobacterium tuberculosis.


Ortholog group members (OG5_140510)

Species Accession Gene Product
Chlamydia trachomatis CT_639   exodeoxyribonuclease V subunit beta
Escherichia coli b2820   exonuclease V (RecBCD complex), beta subunit
Mycobacterium tuberculosis Rv0630c   Probable exonuclease V (beta chain) RecB (exodeoxyribonuclease V beta chain)(exodeoxyribonuclease V polypeptide) (chi-specific e
Mycobacterium ulcerans MUL_0708   exodeoxyribonuclease V (beta chain), RecB


No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Escherichia coli exonuclease V (RecBCD complex), beta subunit Compounds References
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets

Obtained from network model

Ranking Plot

Putative Drugs List

Compound Raw Global Species
0.0368 0.2994 0.2984
0.0408 0.3107 0.3097
0.004 0.5 0.5
0.0408 0.3107 0.3097
0.0408 0.3107 0.3097
0.0408 0.3107 0.3097
0.004 0.5 0.5
0.0408 0.3107 0.3097
0.0408 0.3107 0.3097
0.0388 0.2984 0.2984
0.0073 1 1


Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

2 literature references were collected for this gene.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

No user comments are available for this gene. Log in to add comments, or register.

Enter your comment

User ()
Gene identifier Rv0630c (Mycobacterium tuberculosis), Probable exonuclease V (beta chain) RecB (exodeoxyribonuclease V beta chain)(exodeoxyribonuclease V polypeptide) (chi-specific e
Title for this comment