KEGG   Homo sapiens (human): 23435
Entry
23435             CDS       T01001                                 
Symbol
TARDBP, ALS10, TDP-43
Name
(RefSeq) TAR DNA binding protein
  KO
K23600  TAR DNA-binding protein 43
Organism
hsa  Homo sapiens (human)
Pathway
hsa03015  mRNA surveillance pathway
hsa05014  Amyotrophic lateral sclerosis
hsa05022  Pathways of neurodegeneration - multiple diseases
Network
nt06464  Amyotrophic lateral sclerosis
nt06466  Pathways of neurodegeneration
  Element
N01136  Mutation-caused aberrant TDP43 to electron transfer in Complex I
N01154  TDP-43-regulated splicing
N01155  Mutation-caused aberrant TDP43 to TDP-43-regulated splicing
Disease
H00058  Amyotrophic lateral sclerosis (ALS)
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09120 Genetic Information Processing
  09122 Translation
   03015 mRNA surveillance pathway
    23435 (TARDBP)
 09160 Human Diseases
  09164 Neurodegenerative disease
   05014 Amyotrophic lateral sclerosis
    23435 (TARDBP)
   05022 Pathways of neurodegeneration - multiple diseases
    23435 (TARDBP)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03019 Messenger RNA biogenesis [BR:hsa03019]
    23435 (TARDBP)
Messenger RNA biogenesis [BR:hsa03019]
 Eukaryotic type
  mRNA processing factors
   3' end processing
    Negative regulators of mRNA 3' end processing
     23435 (TARDBP)
SSDB
Motif
Pfam: TDP-43_C TDP43_N RRM_1 RRM_7 RRM_3 RL
Other DBs
NCBI-GeneID: 23435
NCBI-ProteinID: NP_031401
OMIM: 605078
HGNC: 11571
Ensembl: ENSG00000120948
UniProt: Q13148 Q9H256
Structure
Position
1:11012654..11030528
AA seq 414 aa
MSEYIRVTEDENDEPIEIPSEDDGTVLLSTVTAQFPGACGLRYRNPVSQCMRGVRLVEGI
LHAPDAGWGNLVYVVNYPKDNKRKMDETDASSAVKVKRAVQKTSDLIVLGLPWKTTEQDL
KEYFSTFGEVLMVQVKKDLKTGHSKGFGFVRFTEYETQVKVMSQRHMIDGRWCDCKLPNS
KQSQDEPLRSRKVFVGRCTEDMTEDELREFFSQYGDVMDVFIPKPFRAFAFVTFADDQIA
QSLCGEDLIIKGISVHISNAEPKHNSNRQLERSGRFGGNPGGFGNQGGFGNSRGGGAGLG
NNQGSNMGGGMNFGAFSINPAMMAAAQAALQSSWGMMGMLASQQNQSGPSGNNQNQGNMQ
REPNQAFGSGNNSYSGSNSGAAIGWGSASNAGSGSGFNGGFGSSMDSKSSGWGM
NT seq 1245 nt   +upstreamnt  +downstreamnt
atgtctgaatatattcgggtaaccgaagatgagaacgatgagcccattgaaataccatcg
gaagacgatgggacggtgctgctctccacggttacagcccagtttccaggggcgtgtggg
cttcgctacaggaatccagtgtctcagtgtatgagaggtgtccggctggtagaaggaatt
ctgcatgccccagatgctggctggggaaatctggtgtatgttgtcaactatccaaaagat
aacaaaagaaaaatggatgagacagatgcttcatcagcagtgaaagtgaaaagagcagtc
cagaaaacatccgatttaatagtgttgggtctcccatggaaaacaaccgaacaggacctg
aaagagtattttagtacctttggagaagttcttatggtgcaggtcaagaaagatcttaag
actggtcattcaaaggggtttggctttgttcgttttacggaatatgaaacacaagtgaaa
gtaatgtcacagcgacatatgatagatggacgatggtgtgactgcaaacttcctaattct
aagcaaagccaagatgagcctttgagaagcagaaaagtgtttgtggggcgctgtacagag
gacatgactgaggatgagctgcgggagttcttctctcagtacggggatgtgatggatgtc
ttcatccccaagccattcagggcctttgcctttgttacatttgcagatgatcagattgcg
cagtctctttgtggagaggacttgatcattaaaggaatcagcgttcatatatccaatgcc
gaacctaagcacaatagcaatagacagttagaaagaagtggaagatttggtggtaatcca
ggtggctttgggaatcagggtggatttggtaatagcagagggggtggagctggtttggga
aacaatcaaggtagtaatatgggtggtgggatgaactttggtgcgttcagcattaatcca
gccatgatggctgccgcccaggcagcactacagagcagttggggtatgatgggcatgtta
gccagccagcagaaccagtcaggcccatcgggtaataaccaaaaccaaggcaacatgcag
agggagccaaaccaggccttcggttctggaaataactcttatagtggctctaattctggt
gcagcaattggttggggatcagcatccaatgcagggtcgggcagtggttttaatggaggc
tttggctcaagcatggattctaagtcttctggctggggaatgtag

  All links  
Ontology (2)   
   KEGG BRITE (2)   
Pathway (3)   
   KEGG PATHWAY (3)   
Network (5)   
   KEGG NETWORK (5)   
Disease (3)   
   KEGG DISEASE (1)   
   OMIM (2)   
Genome (1)   
   KEGG GENOME (1)   
Gene (23)   
   KEGG ORTHOLOGY (1)   
   RefGene (7)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (10)   
   OC (1)   
Protein sequence (4)   
   UniProt (2)   
   SWISS-PROT (1)   
   RefSeq(pep) (1)   
DNA sequence (67)   
   RefSeq(nuc) (19)   
   GenBank (24)   
   EMBL (24)   
3D Structure (39)   
   PDB (39)   
Protein domain (6)   
   Pfam (6)   
All databases (153)   

Download RDF
DBGET integrated database retrieval system