KEGG T01001: 154

Homo sapiens (human): 154

Entry

154               CDS       T01001

Symbol

ADRB2, ADRB2R, ADRBR, ARB2, B2AR, BAR, BETA2AR

Name

(RefSeq) adrenoceptor beta 2

K04142

adrenergic receptor beta-2

Organism

hsa Homo sapiens (human)

Pathway

hsa04020

Calcium signaling pathway

hsa04022

cGMP-PKG signaling pathway

hsa04024

cAMP signaling pathway

hsa04080

Neuroactive ligand-receptor interaction

hsa04261

Adrenergic signaling in cardiomyocytes

hsa04923

Regulation of lipolysis in adipocytes

hsa04924

Renin secretion

hsa04970

Salivary secretion

hsa05207

Chemical carcinogenesis - receptor activation

Network

nt06214 PI3K signaling (cancer)
nt06234 cAMP signaling (cancer)

Element

N01345

EP/NE-ADRB-cAMP signaling pathway

N01346

Nicotine/NNK to cAMP signaling pathway

N01347

EP/NE-ADRB-PI3K signaling pathway

N01348

Nicotine/NNK to PI3K signaling pathway

Disease

H00079

Asthma

H02106

Genetic obesity

Drug target

Abediterol (DG01232):

D10219 D10220

Adaprolol maleate:

D02765

Alprenolol (DG00303):

D01182 D07156

Alprenoxime hydrochloride:

D02834

Amosulalol (DG01302):

D01469<JP> D07451

Arbutamine:

D02976

Arformoterol (DG01233):

D02981<US> D07463

Arotinolol (DG01303):

D01830<JP> D07465

Bambuterol (DG01060):

D07377 D07489

Batefenterol (DG01627):

D10545 D10546

Bedoradrine sulfate:

D06562

Befunolol (DG01138):

D01512 D07496

Beradilol monoethyl maleate:

D09843

Bitolterol (DG01056):

D00684 D07534

Bopindolol (DG00310):

D01794 D07537

Bucindolol hydrochloride:

D03170

Bucumolol hydrochloride:

D01492

Bufetolol hydrochloride:

D01504<JP>

Bunitrolol hydrochloride:

D01444

Bunolol hydrochloride:

D03177

Bupranolol (DG00311):

D01454 D07590

Butoxamine hydrochloride:

D03198

Carazolol:

D07608

Carbuterol:

D03402

Carteolol (DG00308):

D00599<JP/US> D07624

Carvedilol (DG00321):

D00255<JP/US> D03415<US>

Cimaterol:

D03502

Clenbuterol (DG01053):

D01360<JP> D07713

Cloranolol:

D07183

Clorprenaline hydrochloride:

D01835

Colterol mesylate:

D03587

Dexpropranolol hydrochloride:

D03729

Diacetolol hydrochloride:

D03759

Dilevalol hydrochloride:

D01906

Dipivefrine (DG01129):

D01017 D02349

Dopexamine (DG00222):

D03891 D03892

Droxidopa:

D01277<JP/US>

Ephedrine (DG00227):

D00124 D01386<JP/US> D04018<US>

Epinephrine (DG00013):

D00095<JP/US> D00996 D02149

Epinephryl borate:

D04026

Etafedrine hydrochloride:

D04072

Etilefrine (DG00210):

D01573<JP> D07931

Exaprolol hydrochloride:

D04120

Fenoterol (DG00451):

D01428<JP> D04157

Flestolol sulfate:

D04190

Formoterol (DG01052):

D01373<US> D05277<JP/US> D07990

Hexoprenaline (DG01047):

D02396 D08039

Indacaterol (DG01057):

D09318 D09319<JP> D11009

Indenolol (DG01323):

D01958 D08078

Isoetarine (DG01234):

D02093 D04625 D04626

Isoprenaline (DG00211):

D01390<JP/US> D02066 D02150<JP> D08090

Isoxsuprine (DG00277):

D01748<JP> D08092 D08093

Labetalol (DG00320):

D00600<JP/US> D08106

Levalbuterol

Levosalbutamol (DG01235):

D02281<US> D04701 D04703<US> D08124

Levobunolol (DG01136):

D01025<JP/US> D08115

Mabuterol hydrochloride:

D01589

Medroxalol (DG01317):

D04888 D04889

Mepindolol:

D07181

Metalol hydrochloride:

D04953

Methoxyphenamine:

D01635

Methylephedrine (DG01229):

D01952 D02109<JP> D08206 D09842

Metipranolol (DG01137):

D02081 D02374

Milveterol hydrochloride:

D08945

Nadolol:

D00432<JP/US>

Navafenterol (DG03123):

D11900 D11901

Nipradilol:

D01691<JP>

Norepinephrine (DG00212):

D00076<JP> D05206<US> D08284 D09794

Octodrine:

D05228

Olodaterol (DG01058):

D10020<US> D10145

Orciprenaline (DG01044):

D00685 D04954 D08300

Oxprenolol (DG00304):

D01806 D08318

Pamatolol sulfate:

D05345

Penbutolol (DG00312):

D00602 D08074

Phenylpropanolamine (DG01041):

D01224 D05466 D08368

Picumeterol fumarate:

D05476

Pindolol:

D00513<JP/US>

Pirbuterol (DG01048):

D00686 D01349 D08387

Procaterol (DG01055):

D02404 D05366<JP> D08424

Propranolol (DG00305):

D00483<JP/US> D08443

Pseudoephedrine (DG01042):

D00485 D05648 D05649 D08449

Racephedrine hydrochloride:

D08982

Racepinephrine (DG01444):

D05688 D05689

Ractopamine hydrochloride:

D05691

Reproterol (DG01054):

D05718 D08474

Rimiterol:

D05730

Ritodrine (DG00450):

D01263<JP> D02359

Salbutamol (DG01045):

D00683<JP/US> D02147

Salmeterol (DG01051):

D00687<JP/US> D05792

Sibenadet hydrochloride:

D05832

Sotalol (DG00307):

D01026<JP/US> D08525

Soterenol hydrochloride:

D05902

Talinolol:

D07184

Tazolol hydrochloride:

D06014

Terbutaline (DG01046):

D00688<JP/US> D08570

Tertatolol (DG00309):

D07182 D08572

Tilisolol (DG01322):

D01795 D08598

Timolol (DG00306):

D00378<US> D00603<JP/US> D08600

Tiprenolol hydrochloride:

D06162

Tolamolol:

D06176

Tretoquinol (DG01049):

D01978 D05037<JP> D08629

Tulobuterol (DG01050):

D01362<JP> D02151<JP>

Vilanterol (DG01236):

D09696 D09697

Zinterol hydrochloride:

D06374

Brite

KEGG Orthology (KO) [BR:hsa00001]
09130 Environmental Information Processing
  09132 Signal transduction
   04020 Calcium signaling pathway
    154 (ADRB2)
   04024 cAMP signaling pathway
    154 (ADRB2)
   04022 cGMP-PKG signaling pathway
    154 (ADRB2)
  09133 Signaling molecules and interaction
   04080 Neuroactive ligand-receptor interaction
    154 (ADRB2)
09150 Organismal Systems
  09152 Endocrine system
   04923 Regulation of lipolysis in adipocytes
    154 (ADRB2)
   04924 Renin secretion
    154 (ADRB2)
  09153 Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    154 (ADRB2)
  09154 Digestive system
   04970 Salivary secretion
    154 (ADRB2)
09160 Human Diseases
  09161 Cancer: overview
   05207 Chemical carcinogenesis - receptor activation
    154 (ADRB2)
09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04030 G protein-coupled receptors [BR:hsa04030]
    154 (ADRB2)
G protein-coupled receptors [BR:hsa04030]
Rhodopsin family
  Biogenic amine
   Adrenaline
    154 (ADRB2)

SSDB

Motif

Pfam:

7tm_1 7TM_GPCR_Srsx 7TM_GPCR_Srx 7TM_GPCR_Srv 7tm_4

Other DBs

NCBI-GeneID:

NCBI-ProteinID:

OMIM:

HGNC:

Ensembl:

UniProt:

Structure

Position

5:148826611..148828623

AA seq 413 aa
MGQPGNGSAFLLAPNGSHAPDHDVTQERDEVWVVGMGIVMSLIVLAIVFGNVLVITAIAK
FERLQTVTNYFITSLACADLVMGLAVVPFGAAHILMKMWTFGNFWCEFWTSIDVLCVTAS
IETLCVIAVDRYFAITSPFKYQSLLTKNKARVIILMVWIVSGLTSFLPIQMHWYRATHQE
AINCYANETCCDFFTNQAYAIASSIVSFYVPLVIMVFVYSRVFQEAKRQLQKIDKSEGRF
HVQNLSQVEQDGRTGHGLRRSSKFCLKEHKALKTLGIIMGTFTLCWLPFFIVNIVHVIQD
NLIRKEVYILLNWIGYVNSGFNPLIYCRSPDFRIAFQELLCLRRSSLKAYGNGYSSNGNT
GEQSGYHVEQEKENKLLCEDLPGTEDFVGHQGTVPSDNIDSQGRNCSTNDSLL

NT seq 1242 nt +upstreamnt +downstreamnt
atggggcaacccgggaacggcagcgccttcttgctggcacccaatggaagccatgcgccg
gaccacgacgtcacgcaggaaagggacgaggtgtgggtggtgggcatgggcatcgtcatg
tctctcatcgtcctggccatcgtgtttggcaatgtgctggtcatcacagccattgccaag
ttcgagcgtctgcagacggtcaccaactacttcatcacttcactggcctgtgctgatctg
gtcatgggcctggcagtggtgccctttggggccgcccatattcttatgaaaatgtggact
tttggcaacttctggtgcgagttttggacttccattgatgtgctgtgcgtcacggccagc
attgagaccctgtgcgtgatcgcagtggatcgctactttgccattacttcacctttcaag
taccagagcctgctgaccaagaataaggcccgggtgatcattctgatggtgtggattgtg
tcaggccttacctccttcttgcccattcagatgcactggtaccgggccacccaccaggaa
gccatcaactgctatgccaatgagacctgctgtgacttcttcacgaaccaagcctatgcc
attgcctcttccatcgtgtccttctacgttcccctggtgatcatggtcttcgtctactcc
agggtctttcaggaggccaaaaggcagctccagaagattgacaaatctgagggccgcttc
catgtccagaaccttagccaggtggagcaggatgggcggacggggcatggactccgcaga
tcttccaagttctgcttgaaggagcacaaagccctcaagacgttaggcatcatcatgggc
actttcaccctctgctggctgcccttcttcatcgttaacattgtgcatgtgatccaggat
aacctcatccgtaaggaagtttacatcctcctaaattggataggctatgtcaattctggt
ttcaatccccttatctactgccggagcccagatttcaggattgccttccaggagcttctg
tgcctgcgcaggtcttctttgaaggcctatgggaatggctactccagcaacggcaacaca
ggggagcagagtggatatcacgtggaacaggagaaagaaaataaactgctgtgtgaagac
ctcccaggcacggaagactttgtgggccatcaaggtactgtgcctagcgataacattgat
tcacaagggaggaattgtagtacaaatgactcactgctgtaa

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