KEGG   Homo sapiens (human): 7301
Entry
7301              CDS       T01001                                 
Symbol
TYRO3, BYK, Dtk, Etk-2, RSE, Rek, Sky, Tif
Name
(RefSeq) TYRO3 protein tyrosine kinase
  KO
K05116  TYRO3 protein tyrosine kinase 3 [EC:2.7.10.1]
Organism
hsa  Homo sapiens (human)
Pathway
hsa03264  Virion - Flavivirus
hsa04148  Efferocytosis
Drug target
Zanzalintinib (DG03273): D12650 D12651
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09120 Genetic Information Processing
  09125 Information processing in viruses
   03264 Virion - Flavivirus
    7301 (TYRO3)
 09140 Cellular Processes
  09141 Transport and catabolism
   04148 Efferocytosis
    7301 (TYRO3)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:hsa01001]
    7301 (TYRO3)
Enzymes [BR:hsa01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.10  Protein-tyrosine kinases
    2.7.10.1  receptor protein-tyrosine kinase
     7301 (TYRO3)
Protein kinases [BR:hsa01001]
 Receptor tyrosine kinases (RTK)
  AXL family
   7301 (TYRO3)
SSDB
Motif
Pfam: PK_Tyr_Ser-Thr Pkinase Ig_3 Ig_2 fn3 I-set ig V-set Pur_ac_phosph_N C1-set DUF4229
Other DBs
NCBI-GeneID: 7301
NCBI-ProteinID: NP_006284
OMIM: 600341
HGNC: 12446
Ensembl: ENSG00000092445
UniProt: Q06418
Structure
Position
15:41559212..41583589
AA seq 890 aa
MALRRSMGRPGLPPLPLPPPPRLGLLLAALASLLLPESAAAGLKLMGAPVKLTVSQGQPV
KLNCSVEGMEEPDIQWVKDGAVVQNLDQLYIPVSEQHWIGFLSLKSVERSDAGRYWCQVE
DGGETEISQPVWLTVEGVPFFTVEPKDLAVPPNAPFQLSCEAVGPPEPVTIVWWRGTTKI
GGPAPSPSVLNVTGVTQSTMFSCEAHNLKGLASSRTATVHLQALPAAPFNITVTKLSSSN
ASVAWMPGADGRALLQSCTVQVTQAPGGWEVLAVVVPVPPFTCLLRDLVPATNYSLRVRC
ANALGPSPYADWVPFQTKGLAPASAPQNLHAIRTDSGLILEWEEVIPEAPLEGPLGPYKL
SWVQDNGTQDELTVEGTRANLTGWDPQKDLIVRVCVSNAVGCGPWSQPLVVSSHDRAGQQ
GPPHSRTSWVPVVLGVLTALVTAAALALILLRKRRKETRFGQAFDSVMARGEPAVHFRAA
RSFNRERPERIEATLDSLGISDELKEKLEDVLIPEQQFTLGRMLGKGEFGSVREAQLKQE
DGSFVKVAVKMLKADIIASSDIEEFLREAACMKEFDHPHVAKLVGVSLRSRAKGRLPIPM
VILPFMKHGDLHAFLLASRIGENPFNLPLQTLIRFMVDIACGMEYLSSRNFIHRDLAARN
CMLAEDMTVCVADFGLSRKIYSGDYYRQGCASKLPVKWLALESLADNLYTVQSDVWAFGV
TMWEIMTRGQTPYAGIENAEIYNYLIGGNRLKQPPECMEDVYDLMYQCWSADPKQRPSFT
CLRMELENILGQLSVLSASQDPLYINIERAEEPTAGGSLELPGRDQPYSGAGDGSGMGAV
GGTPSDCRYILTPGGLAEQPGQAEHQPESPLNETQRLLLLQQGLLPHSSC
NT seq 2673 nt   +upstreamnt  +downstreamnt
atggcgctgaggcggagcatggggcggccggggctcccgccgctgccgctgccgccgcca
ccgcggctcgggctgctgctggcggctctggcttctctgctgctcccggagtccgccgcc
gcaggtctgaagctcatgggagccccggtgaagctgacagtgtctcaggggcagccggtg
aagctcaactgcagtgtggaggggatggaggagcctgacatccagtgggtgaaggatggg
gctgtggtccagaacttggaccagttgtacatcccagtcagcgagcagcactggatcggc
ttcctcagcctgaagtcagtggagcgctctgacgccggccggtactggtgccaggtggag
gatgggggtgaaaccgagatctcccagccagtgtggctcacggtagaaggtgtgccattt
ttcacagtggagccaaaagatctggcagtgccacccaatgcccctttccaactgtcttgt
gaggctgtgggtccccctgaacctgttaccattgtctggtggagaggaactacgaagatc
gggggacccgctccctctccatctgttttaaatgtaacaggggtgacccagagcaccatg
ttttcctgtgaagctcacaacctaaaaggcctggcctcttctcgcacagccactgttcac
cttcaagcactgcctgcagcccccttcaacatcaccgtgacaaagctttccagcagcaac
gctagtgtggcctggatgccaggtgctgatggccgagctctgctacagtcctgtacagtt
caggtgacacaggccccaggaggctgggaagtcctggctgttgtggtccctgtgcccccc
tttacctgcctgctccgggacctggtgcctgccaccaactacagcctcagggtgcgctgt
gccaatgccttggggccctctccctatgctgactgggtgccctttcagaccaagggtcta
gccccagccagcgctccccaaaacctccatgccatccgcacagattcaggcctcatcttg
gagtgggaagaagtgatccccgaggcccctttggaaggccccctgggaccctacaaactg
tcctgggttcaagacaatggaacccaggatgagctgacagtggaggggaccagggccaat
ttgacaggctgggatccccaaaaggacctgatcgtacgtgtgtgcgtctccaatgcagtt
ggctgtggaccctggagtcagccactggtggtctcttctcatgaccgtgcaggccagcag
ggccctcctcacagccgcacatcctgggtacctgtggtccttggtgtgctaacggccctg
gtgacggctgctgccctggccctcatcctgcttcgaaagagacggaaagagacgcggttt
gggcaagcctttgacagtgtcatggcccggggagagccagccgttcacttccgggcagcc
cggtccttcaatcgagaaaggcccgagcgcatcgaggccacattggacagcttgggcatc
agcgatgaactaaaggaaaaactggaggatgtgctcatcccagagcagcagttcaccctg
ggccggatgttgggcaaaggagagtttggttcagtgcgggaggcccagctgaagcaagag
gatggctcctttgtgaaagtggctgtgaagatgctgaaagctgacatcattgcctcaagc
gacattgaagagttcctcagggaagcagcttgcatgaaggagtttgaccatccacacgtg
gccaaacttgttggggtaagcctccggagcagggctaaaggccgtctccccatccccatg
gtcatcttgcccttcatgaagcatggggacctgcatgccttcctgctcgcctcccggatt
ggggagaacccctttaacctacccctccagaccctgatccggttcatggtggacattgcc
tgcggcatggagtacctgagctctcggaacttcatccaccgagacctggctgctcggaat
tgcatgctggcagaggacatgacagtgtgtgtggctgacttcggactctcccggaagatc
tacagtggggactactatcgtcaaggctgtgcctccaaactgcctgtcaagtggctggcc
ctggagagcctggccgacaacctgtatactgtgcagagtgacgtgtgggcgttcggggtg
accatgtgggagatcatgacacgtgggcagacgccatatgctggcatcgaaaacgctgag
atttacaactacctcattggcgggaaccgcctgaaacagcctccggagtgtatggaggac
gtgtatgatctcatgtaccagtgctggagtgctgaccccaagcagcgcccgagctttact
tgtctgcgaatggaactggagaacatcttgggccagctgtctgtgctatctgccagccag
gaccccttatacatcaacatcgagagagctgaggagcccactgcgggaggcagcctggag
ctacctggcagggatcagccctacagtggggctggggatggcagtggcatgggggcagtg
ggtggcactcccagtgactgtcggtacatactcacccccggagggctggctgagcagcca
gggcaggcagagcaccagccagagagtcccctcaatgagacacagaggcttttgctgctg
cagcaagggctactgccacacagtagctgttag

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Ontology (3)   
   KEGG BRITE (3)   
Pathway (2)   
   KEGG PATHWAY (2)   
Disease (1)   
   OMIM (1)   
Drug (2)   
   KEGG DRUG (2)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (16)   
   KEGG ORTHOLOGY (1)   
   RefGene (6)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (4)   
   OC (1)   
Protein sequence (6)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (4)   
DNA sequence (32)   
   RefSeq(nuc) (4)   
   GenBank (14)   
   EMBL (14)   
3D Structure (1)   
   PDB (1)   
Protein domain (11)   
   Pfam (11)   
All databases (76)   

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