pI: 5.1201 |
Length (AA): 286 |
MW (Da): 29779 |
Paralog Number:
2
Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 3 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
3 | 284 | 2et6 (A) | 5 | 285 | 47.00 | 0 | 1 | 1.51831 | -0.25 |
3 | 282 | 1gz6 (A) | 6 | 285 | 51.00 | 0 | 1 | 1.59332 | -0.37 |
7 | 242 | 1edo (A) | 18 | 257 | 34.00 | 0 | 1 | 1.21537 | -0.78 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Upper 80-100% percentile | Dormant phase. | murphy |
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Lower 20-40% percentile | Dormant phase. | hasan |
hasan | Prioritizing genomic drug targets in pathogens: application to Mycobacterium tuberculosis. |
murphy | Identification of gene targets against dormant phase Mycobacterium tuberculosis infections. |
Ortholog group members (OG5_129142)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT1G76150 | enoyl-CoA hydratase 2 |
Brugia malayi | Bm1_44740 | oxidoreductase, short chain dehydrogenase/reductase family protein |
Brugia malayi | Bm1_24050 | maoC like domain containing protein |
Candida albicans | CaO19.1809 | similar to C.tropicalis HDE1 (P22414) peroxisomal trifunctional hydratase-dehydrogenase-epimerase important in fatty acid beta-o |
Caenorhabditis elegans | CELE_E04F6.3 | Protein MAOC-1 |
Caenorhabditis elegans | CELE_M03A8.1 | Protein DHS-28 |
Dictyostelium discoideum | DDB_G0291247 | hypothetical protein |
Dictyostelium discoideum | DDB_G0277911 | hypothetical protein |
Drosophila melanogaster | Dmel_CG3415 | peroxisomal Multifunctional enzyme type 2 |
Homo sapiens | ENSG00000133835 | hydroxysteroid (17-beta) dehydrogenase 4 |
Loa Loa (eye worm) | LOAG_08780 | short chain dehydrogenase/reductase family oxidoreductase |
Loa Loa (eye worm) | LOAG_00696 | hypothetical protein |
Mus musculus | ENSMUSG00000024507 | hydroxysteroid (17-beta) dehydrogenase 4 |
Mycobacterium tuberculosis | Rv0148 | Probable short-chain type dehydrogenase/reductase |
Mycobacterium tuberculosis | Rv3389c | Probable 3-hydroxyacyl-thioester dehydratase HtdY |
Mycobacterium tuberculosis | Rv3538 | Probable dehydrogenase. Possible 2-enoyl acyl-CoA hydratase. |
Mycobacterium ulcerans | MUL_4099 | dehydratase |
Mycobacterium ulcerans | MUL_0920 | hypothetical protein |
Mycobacterium ulcerans | MUL_4759 | short-chain type dehydrogenase/reductase |
Mycobacterium ulcerans | MUL_4812 | short-chain type dehydrogenase/reductase |
Neospora caninum | NCLIV_042220 | peroxisomal multifunctional enzyme type 2, putative |
Neospora caninum | NCLIV_030080 | peroxisomal multifunctional enzyme, putative |
Oryza sativa | 4347752 | Os09g0544900 |
Saccharomyces cerevisiae | YKR009C | bifunctional hydroxyacyl-CoA dehydrogenase/enoyl-CoA hydratase FOX2 |
Schmidtea mediterranea | mk4.001730.03 | |
Schmidtea mediterranea | mk4.007769.01 | Peroxisomal multifunctional enzyme type 2 |
Toxoplasma gondii | TGME49_234570 | sterol carrier protein-2 HAD-2SCP-2 |
Toxoplasma gondii | TGME49_229140 | MaoC family domain-containing protein |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
mtu149 this record | Mycobacterium tuberculosis | non-essential | nmpdr |
mtu3449 | Mycobacterium tuberculosis | non-essential | nmpdr |
mtu3599 | Mycobacterium tuberculosis | essential | nmpdr |
CELE_M03A8.1 | Caenorhabditis elegans | larval arrest | wormbase |
CELE_M03A8.1 | Caenorhabditis elegans | slow growth | wormbase |
CELE_E04F6.3 | Caenorhabditis elegans | larval arrest | wormbase |
TGME49_229140 | Toxoplasma gondii | Essentiality uncertain | sidik |
TGME49_234570 | Toxoplasma gondii | Essentiality uncertain | sidik |
TGME49_229140 | Toxoplasma gondii | Probably non-essential | sidik |
TGME49_234570 | Toxoplasma gondii | Probably non-essential | sidik |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
Druggability index (range: 0 to 1): 0.6
Species | Known druggable target | Linked compounds | Reference |
---|---|---|---|
Homo sapiens | hydroxysteroid (17-beta) dehydrogenase 4 | Compounds | References |