Detailed view for Rv1200

Basic information

TDR Targets ID: 7805
Mycobacterium tuberculosis, Probable conserved integral membrane transport protein

Source Database / ID:  Tuberculist 

pI: 9.373 | Length (AA): 425 | MW (Da): 44575 | Paralog Number: 0

Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 12

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00083   Sugar (and other) transporter

Gene Ontology

Mouse over links to read term descriptions.
GO:0022857   transmembrane transporter activity  
GO:0016021   integral to membrane  
GO:0005215   transporter activity  
GO:0055085   transmembrane transport  
GO:0006810   transport  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 5 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
3 422 4j05 (A) 33 507 15.00 0 0.31 1.11624 -0.03
3 419 4j05 (A) 33 504 26.00 0.00000000058 0.83 1.18628 0.39
4 422 4gc0 (A) 13 471 28.00 0.00000000068 0.96 1.10698 0.76
7 409 4tph (A) 13 483 22.00 0 0.97 0.950235 0.68
225 351 4mi2 (A) 95 214 33.00 0.22 0.69 0.382924 1.26

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

Upregulation Percent Ranking Stage Dataset
Upper 80-100% percentile Dormant phase. hasan
Upregulation Percent Ranking Stage Dataset
Mid 40-60% percentile Dormant phase. murphy
Show/Hide expression data references
  • murphy Identification of gene targets against dormant phase Mycobacterium tuberculosis infections.
  • hasan Prioritizing genomic drug targets in pathogens: application to Mycobacterium tuberculosis.

Orthologs

Ortholog group members (OG5_129851)

Species Accession Gene Product
Escherichia coli b4111   proline/glycine betaine transporter
Escherichia coli b3523   MFS superfamily sugar transport 1 family protein
Mycobacterium tuberculosis Rv1200   Probable conserved integral membrane transport protein
Mycobacterium ulcerans MUL_0949   integral membrane transport protein
Treponema pallidum TP0840   hypothetical protein
Wolbachia endosymbiont of Brugia malayi Wbm0167   major facilitator superfamily permease
Wolbachia endosymbiont of Brugia malayi Wbm0011   major facilitator superfamily permease

Essentiality

Rv1200 has direct evidence of essentiality
Gene/Ortholog Organism Phenotype Source Study
mtu1221 this record Mycobacterium tuberculosis non-essential nmpdr
b3523 Escherichia coli non-essential goodall
b4111 Escherichia coli non-essential goodall
Show/Hide essentiality data references
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.


Annotated validation

No validation data for this target

Associated compounds / Druggability

Druggability index (range: 0 to 1): 0.1


Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets

Obtained from network model

Ranking Plot


Putative Drugs List


Compound Raw Global Species
0.0869 0.3613 0.5
0.0852 0.3794 0.5
0.0854 0.368 0.5
0.0761 0.7227 0.5
0.0885 0.38 0.5
0.0912 0.3836 0.5
0.092 0.3639 0.5
0.0801 0.5193 1
0.0849 0.3822 0.5
0.0662 0.6327 0.5
0.0006 0.5 0.5
0.0681 0.282 0.5
0.0905 0.392 0.5
0.0856 0.3899 0.5
0.0866 0.3965 0.5
0.089 0.2727 1
0.0701 0.6673 0.5
0.0934 0.3952 1
0.0006 0.5 0.5
0.0852 0.3669 0.5
0.0859 0.3889 0.5
0.0779 0.2877 1
0.0808 0.3589 1
0.0901 0.3833 0.5
0.0731 0.6098 1
0.0898 0.388 0.5
0.0904 0.385 0.5
0.0855 0.3965 0.5
0.0788 0.3469 0.5
0.0955 0.3879 0.5
0.0026 0.5 0.5
0.086 0.4118 1
0.0006 0.5 0.5
0.0931 0.3822 0.5
0.0372 0.3723 0.5
0.0937 0.3983 0.5
0.0779 0.7604 0.5
0.0838 0.798 0.5
0.0805 0.3768 0.5
0.0848 0.3654 0.5
0.0017 0.5 0.5
0.0906 0.3653 0.5
0.0006 0.5 0.5
0.0909 0.3804 0.5
0.0086 0.5 0.5
0.0908 0.4056 1
0.0731 0.7159 1
0.0006 0.5 0.5
0.0822 0.3544 0.5
0.0757 0.2571 1
0.0152 0.339 0.5
0.0705 0.2788 0.5
0.0778 0.2723 0.5
0.0885 0.3952 0.5
0.0887 0.3854 0.5
0.0801 0.3587 0.5
0.0835 0.7944 0.5
0.0877 0.3703 0.5
0.0701 0.6657 0.5
0.0124 0.5 0.5
0.0931 0.4131 0.5
0.0699 0.3137 1
0.0906 0.4211 1
0.0855 0.4048 0.5
0.0902 0.3872 0.5
0.0878 0.4008 1
0.0891 0.4065 0.5
0.0916 0.4286 1
0.082 0.3993 1
0.0861 0.3665 1
0.0649 0.5 0.5
0.0919 0.4066 0.5
0.0395 0.4327 0.5
0.0684 0.661 1
0.0636 0.5945 0.5
0.0006 0.5 0.5
0.0759 0.7344 0.5
0.0888 0.4111 1
0.0802 0.3726 0.5
0.0828 0.3611 1
0.0026 0.4542 0.5
0.0933 0.3903 0.5
0.0778 0.2723 0.5
0.0676 0.4278 1
0.0931 0.4131 0.5
0.001 0.5 0.5
0.0104 0.4448 0.5
0.0052 0.3137 0.7001
0.0744 0.3371 1
0.0026 0.5 0.5
0.0836 0.4016 1
0.0808 0.7747 0.5
0.0218 0.2749 1
0.0691 0.6563 0.5
0.088 0.3774 0.5
0.0801 0.5193 1
0.0006 0.5 0.5
0.0933 0.3971 1
0.0954 0.378 0.5
0.0565 0.513 0.5
0.0808 0.3589 1
0.0703 0.282 0.5
0.0785 0.3546 1
0.0785 0.7428 0.5
0.0881 0.4196 1
0.0875 0.4019 0.5
0.0911 0.3866 0.5
0.0882 0.383 0.5
0.0693 0.2676 0.5
0.0693 0.3086 1
0.0862 0.3709 1
0.0883 0.4017 0.5
0.0938 0.3795 0.5
0.0705 0.673 0.5
0.0906 0.4211 1
0.0026 0.2589 0.5
0.0886 0.3725 1
0.0847 0.3728 1
0.0786 0.3708 0.5
0.0801 0.3419 0.5
0.0851 0.3655 0.5
0.0839 0.3687 0.5
0.0473 0.4582 0.5
0.0934 0.355 0.3545
0.0737 0.7131 0.5
0.0692 0.2863 0.5
0.0789 0.351 1
0.0919 0.3894 0.5
0.0945 0.3769 0.5
0.0788 0.3469 0.5
0.0766 0.3381 1
0.0856 0.3829 0.5
0.0006 0.5 0.5
0.0814 0.3388 0.5
0.0872 0.3879 0.5
0.0858 0.3951 0.5
0.0859 0.3676 0.5
0.0815 0.3701 1
0.0872 0.3682 0.5
0.0731 0.7159 1
0.0825 0.381 0.5
0.0902 0.384 0.5
0.0911 0.3937 1
0.0867 0.3611 0.5
0.0782 0.3584 1
0.0825 0.395 0.5
0.0811 0.3835 0.5
0.0578 0.5 0.5
0.0006 0.5 0.5
0.0924 0.363 0.5
0.0676 0.4278 1
0.0808 0.4976 1
0.0019 0.3675 0.5
0.0932 0.3859 0.5
0.0917 0.76 0.5
0.0115 0.8254 0.5
0.0725 0.3007 0.5
0.0602 0.2622 0.5
0.09 0.3856 0.5
0.0904 0.388 0.5
0.0771 0.3215 0.5
0.0746 0.2979 1
0.0215 1 1
0.09 0.368 0.5
0.08 0.3562 1
0.0879 0.3794 1
0.0863 0.3613 0.5
0.0006 0.5 0.5
0.0851 0.3655 0.5
0.0832 0.3853 0.5
0.0242 1 1
0.0967 0.3866 0.5
0.0947 0.3919 0.5
0.0785 0.3546 1
0.0115 0.8254 0.5
0.0904 0.3997 0.5
0.0746 0.2979 1
0.0846 0.3834 0.5
0.0016 0.5 0.5
0.0778 0.2723 0.5
0.0006 0.5 0.5
0.0443 0.5 0.5
0.0902 0.3808 0.5
0.0858 0.401 0.5
0.0072 0.5 0.5
0.0661 0.3105 1
0.0906 0.3708 0.5
0.0676 0.4278 1
0.0893 0.3833 0.5
0.0859 0.3771 0.5
0.0913 0.4084 0.5
0.0824 0.7893 0.5
0.0604 0.5795 0.5
0.0778 0.2723 0.5
0.038 0.5 0.5
0.0784 0.766 0.5
0.0943 0.4376 1
0.0869 0.3805 0.5
0.0614 0.4905 0.5
0.0766 0.3381 1
0.0891 0.3748 0.5
0.0708 0.6913 0.5

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

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User comments

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Gene identifier Rv1200 (Mycobacterium tuberculosis), Probable conserved integral membrane transport protein
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