Detailed view for EHI_108670

Basic information

TDR Targets ID: 797773
Entamoeba histolytica, protein kinase domain containing protein
Source Database / ID:  AmoebaDB  

pI: 9.2999 | Length (AA): 394 | MW (Da): 46541 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00069   Protein kinase domain

Gene Ontology

Mouse over links to read term descriptions.
GO:0005524   ATP binding  
GO:0004672   protein kinase activity  
GO:0006468   protein amino acid phosphorylation  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 5 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
12 305 4au8 (A) 1 288 39.00 0 1 1.23669 -0.97
13 333 5efq (A) 703 1025 39.00 0 1 1.32842 -0.89
13 311 3blh (A) 17 323 44.00 0 1 1.28238 -0.8
13 233 2f2u (A) 90 308 30.00 0 1 0.854614 -0.19
15 391 5o2c (A) 147 496 23.00 0 1 1.09355 -0.04

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

Upregulation Percent Ranking Stage Dataset
Mid 40-60% percentile Trophozoite, Rahman HM-1 IMSS Trophozoite. Hon CC
Show/Hide expression data references
  • Hon CC Transcriptomics of virulent and avirulent strains

Orthologs

Ortholog group members (OG5_130531)

Species Accession Gene Product
Brugia malayi Bm1_20615   cyclin-dependent kinase 9
Candida albicans CaO19.11006   CDC2-related protein kinase
Candida albicans CaO19.3524   similar ot C terminus of S. cerevisiae SGV1 (YPR161C)
Caenorhabditis elegans CELE_M04D5.4   Protein CDK-9, isoform A
Caenorhabditis elegans CELE_H25P06.2   Protein CDK-9, isoform B
Drosophila melanogaster Dmel_CG5179   Cyclin-dependent kinase 9
Echinococcus granulosus EgrG_000627050   cyclin dependent kinase 9
Echinococcus granulosus EgrG_000596200   cyclin dependent kinase 9
Entamoeba histolytica EHI_108670   protein kinase domain containing protein
Echinococcus multilocularis EmuJ_000596200   cyclin dependent kinase 9
Echinococcus multilocularis EmuJ_000627050   cyclin dependent kinase 9
Homo sapiens ENSG00000136807   cyclin-dependent kinase 9
Loa Loa (eye worm) LOAG_13620   CMGC/CDK/CDK9 protein kinase
Mus musculus 107951   cyclin-dependent kinase 9 (CDC2-related kinase)
Saccharomyces cerevisiae YPR161C   Sgv1p
Schistosoma japonicum Sjp_0217060   ko:K02211 cyclin-dependent kinase 9, putative
Schistosoma japonicum Sjp_0025570   ko:K02211 cyclin-dependent kinase 9, putative
Schistosoma mansoni Smp_094760   serine/threonine protein kinase
Schistosoma mansoni Smp_003000   kinase
Schmidtea mediterranea mk4.012948.00  
Schmidtea mediterranea mk4.000003.28  
Schmidtea mediterranea mk4.009317.00  

Essentiality

EHI_108670 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
CELE_H25P06.2 Caenorhabditis elegans embryonic arrest wormbase
CELE_H25P06.2 Caenorhabditis elegans embryonic lethal wormbase
CELE_H25P06.2 Caenorhabditis elegans larval arrest wormbase
CELE_H25P06.2 Caenorhabditis elegans slow growth wormbase
YPR161C Saccharomyces cerevisiae inviable yeastgenome
Show/Hide essentiality data references
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Homo sapiens cyclin-dependent kinase 9 Compounds References
By sequence similarity to non orthologous druggable targets
Species Target Length Identity Alignment span Linked Drugs Reference
Patiria pectinifera Cdc2 300 aa 38.6% 295 aa Compounds References
Xenopus laevis Aurora kinase B-A 361 aa 25.5% 314 aa Compounds References
Schizosaccharomyces pombe 972h- Casein kinase II subunit alpha 332 aa 27.6% 301 aa Compounds References
Plasmodium falciparum (isolate 3D7) Cell division control protein 2 homolog 288 aa 38.0% 300 aa Compounds References
Oryctolagus cuniculus Cyclin-dependent kinase 4 189 aa 39.9% 173 aa Compounds References
Rattus norvegicus MAP kinase p38 alpha 360 aa 32.9% 316 aa Compounds References
Xenopus laevis Aurora kinase B-B 368 aa 25.5% 314 aa Compounds References
Rattus norvegicus Mitogen-activated protein kinase 1 358 aa 32.5% 298 aa Compounds References
Rattus norvegicus Cell division protein kinase 5 292 aa 38.4% 294 aa Compounds References
Zea mays Casein kinase II alpha 332 aa 28.1% 303 aa Compounds References
Homo sapiens Cyclin-dependent kinase 1/cyclin B1 297 aa 39.2% 293 aa Compounds References
Obtained from network model

Ranking Plot

Putative Drugs List

Compound Raw Global Species
0.0055 0.8246 1
0.0055 0.8246 1
0.0055 0.8246 1
0.0016 0.5 0.5
0.0055 0.8246 1
0.0059 1 1
0.0055 0.8246 0.8668
0.0371 0.8258 1
0.0047 0.703 0.709
0.0055 0.8258 1
0.3997 0.8265 1
0.0539 0.6884 1
0.0645 0.6662 1
0.0593 0.4121 1
0.0845 0.8258 1
0.0481 0.4414 0.8435
0.0055 0.4938 1
0.323 0.829 1
0.0566 0.8419 1
0.3844 0.8387 1
0.0055 0.8246 1
0.1712 0.8258 1
0.0751 0.356 0.9826
0.2895 0.8503 1
0.0055 0.8258 1
0.1782 0.3156 1
0.0055 0.8246 1
0.0458 0.8258 1
0.2072 0.845 1
0.1546 0.8246 0.893
0.1421 0.8505 0.9134
0.393 0.8498 1
0.1757 0.8258 1
0.0647 0.6555 1
0.0033 0.5 0.5
0.0314 0.8246 1
0.0189 0.8246 0.8668
0.0472 0.8258 1
0.0406 0.8485 1
0.0055 0.8246 1
0.0702 0.8499 1
0.0798 0.3701 0.5908
0.0656 0.8482 1
0.1098 0.325 0.9828
0.1709 0.8282 1
0.0853 0.8258 1
0.4396 0.8514 1
0.0551 0.8246 1
0.0055 0.8246 0.8668
0.0055 0.8333 1
0.0426 0.7536 1
0.0155 0.2867 0.3389
0.0055 0.8246 1
0.0055 0.8246 0.8668
0.1569 0.8513 1
0.0876 0.3223 0.7433
0.1114 0.65 1
0.3991 0.5098 1
0.0094 0.296 1
0.0733 0.634 0.703
0.0553 0.4195 0.7629
0.127 0.8503 1
0.0812 0.8258 1
0.0333 0.4586 0.4439
0.0036 0.5 0.5
0.0055 0.732 1
0.0507 0.8258 1
0.0055 0.8246 1
0.1107 0.3396 0.759
0.0136 0.3817 0.3817
0.1155 0.3925 1
0.0751 0.356 0.9826
0.1057 0.8409 0.9081
0.0821 0.4858 0.6484
0.1154 0.8509 0.8875
0.1175 0.8258 1
0.1179 0.4738 0.8691
0.0592 0.3035 1
0.0334 0.8468 1
0.0575 0.8258 1
0.0151 0.5332 1
0.117 0.8246 0.9034
0.0715 0.8502 1
0.0518 0.8505 1
0.0574 0.2698 0.6291
0.0133 0.8258 1
0.0753 0.3791 0.7684
0.0055 0.8246 0.8668
0.1944 0.851 1
0.0755 0.8411 1
0.0045 0.7201 1
0.0577 0.3079 0.6169
0.0055 0.8246 1
0.0027 1 0.5
0.0055 0.8246 1
0.0939 0.8502 0.9263
0.0055 0.8246 1
0.01 0.308 0.6778
0.3798 0.8513 1
0.0055 0.8246 1
0.1154 0.8509 0.8875
0.108 0.4892 1
0.0997 0.5219 0.922
0.0361 0.8366 1
0.0235 0.3033 0.5012
0.0022 0.5 0.5
0.0093 0.3215 1
0.0055 0.8246 0.8668
0.0007 0.5 0.5
0.0722 0.632 1
0.2678 0.8451 1
0.0552 0.847 1
0.0803 0.3168 0.6606
0.0055 0.2645 1
0.0055 0.8246 1
0.1461 0.8509 1
0.0097 0.8246 1
0.0139 0.8278 1
0.4868 0.8496 1
0.0055 0.761 1
0.0055 0.8246 1
0.1341 0.8502 0.9026
0.0441 0.2556 0.3981
0.0045 0.4265 0.4265
0.1709 0.8282 1
0.2014 0.6636 1
0.0055 0.8246 0.8668
0.0424 0.8258 1
0.0335225 0.293039 0.293039
0.0055 0.8246 0.8668
0.166 0.8258 1
0.0137 0.2818 0.6737
0.1336 0.8412 0.9005
0.0242 0.6202 0.6202
0.0055 0.8246 1
0.1095 0.635 1
0.0055 0.8246 0.8668
0.0055 0.8246 1
0.0153 0.4663 1
0.1462 0.8507 1
0.0907 0.5483 1
0.093 0.5494 1
0.3015 0.851 1
0.0055 0.8246 1
0.0788 0.3561 1
0.4061 0.8512 1
0.0055 0.8246 1
0.0708 0.3462 0.9791
0.0045 0.2604 1
0.0774 0.8246 0.8668
0.0773 0.4565 0.6311
0.1295 0.75 1
0.0796 0.8485 1
0.0585 0.3649 1
0.1719 0.8497 1
0.0932 0.2836 0.671
0.0055 0.8246 0.8668
0.0185 0.2769 0.7135
0.0377 0.8258 1
0.049 0.5978 1
0.1079 0.3419 0.7348
0.0293 0.3718 1
0.0055 0.8246 1
0.0374 0.8494 1
0.011 0.2601 1
0.1076 0.8505 1
0.0095 0.8258 1
0.0093 0.3249 1
0.155 0.8376 0.895
0.0055 0.8246 1
0.042 0.8455 1
0.0055 0.8246 1
0.0191 0.8472 1
0.0045 0.7201 1
0.0055 0.8011 1
0.1154 0.8509 0.8875
0.0033 1 1
0.0481 0.4414 0.8435
0.1547 0.8275 0.8968
0.0336 0.8246 1
0.0527 0.8258 1
0.0055 0.8258 1
0.015 0.2539 0.5674
0.0081 1 0.5
0.0289 0.318 1
0.2095 0.8246 1
0.0481 0.4414 0.8435
0.1917 0.5958 1
0.1411 0.8506 1
0.0426 0.7536 1
0.1228 0.4981 0.896
0.0931 0.8508 1
0.0055 0.8246 0.8668
0.109 0.8258 1
0.0256 0.4092 1
0.3997 0.8265 1
0.0323 0.3741 1
0.0715 0.8502 1
0.0055 0.8246 1
0.0407 0.8246 1
0.1719 0.8497 1
0.0053 0.7755 0.2774
0.1666 0.8495 1
0.1047 0.4105 0.8783
0.0045 0.2945 1
0.0249 0.2932 0.6778
0.0853 0.8258 1
0.1114 0.65 1
0.03 0.2539 0.5674
0.0039 0.5 0.5
0.1758 0.8449 1
0.0756 0.8246 1
0.3922 0.8261 1
0.0012 0.5 0.5
0.3724 0.8511 1
0.0055 0.8246 0.8668
0.4445 0.8511 1
0.0484 0.3693 0.6624
0.0155 0.2867 0.3389
0.0142 0.2509 0.5674
0.1104 0.8455 1
0.0732 0.74 1
0.0097 0.5094 1
0.0245 0.2636 0.7477
0.1047 0.4105 0.8783
0.1421 0.8505 0.9134
0.0055 0.8246 1
0.037 0.5378 1
0.0104 0.4841 0.4568
0.0675 0.8258 1
0.0055 0.8246 0.8668
0.0039 0.5 0.5
0.0478 0.5672 1
0.2611 0.2502 1
0.0055 0.8246 1
0.0718 0.6731 1
0.02 0.8246 1
0.1392 0.3868 1
0.0055 0.8246 1
0.0055 0.8246 1
0.0032 0.5 0.5
0.1368 0.8326 0.9027
0.0877 0.8442 1
0.1079 0.3419 0.7348
0.0438 0.8196 0.5
0.005 0.8246 0.8668
0.0055 0.2539 0.5674
0.0352 0.8474 1
0.0055 0.8246 1
0.0758 0.7782 1
0.2338 0.8498 1
0.0062 0.6935 0
0.0577 0.8258 1
0.0055 0.8246 1
0.1866 0.8509 1
0.1748 0.8508 1
0.0607 0.3916 0.7253
0.0499 0.364 1
0.3163 0.8444 1
0.032 0.8258 1
0.0303 0.8499 1
0.0055 0.8246 1
0.3821 0.8513 1
0.0055 0.8246 0.8668
0.0647 0.8258 1
0.0605 0.3969 0.5988
0.0815 0.6227 0.6829
0.1079 0.8258 1
0.0155 0.5798 0.6685
0.0156 0.8258 1
0.0096 0.3477 1
0.0561 0.6686 0.887
0.0318 0.8258 1
0.1206 0.8499 1
0.0289 0.318 1
0.0925 0.8258 1
0.0055 0.8246 0.8668
0.0055 0.8246 0.8668
0.0139 0.4137 0.2079
0.1025 0.4981 1
0.0926 0.8258 1
0.0011 1 0.5
0.1298 0.7615 1
0.3455 0.8346 1
0.019 0.8246 1
0.1446 0.8503 1
0.0871 0.4724 0.8868
0.0055 0.8246 1
0.0418 0.8491 1
0.4035 0.8515 1
0.0333 0.4586 0.4439
0.0647 0.8258 1
0.1546 0.8246 0.893
0.0335225 0.293039 0.293039
0.0578 0.8489 1
0.0736 0.5199 1
0.3616 0.8494 1
0.0523 0.6654 1
0.0012 0.5 0.5
0.0045 0.7201 1
0.0089 0.2562 0.4224
0.1098 0.325 0.9828
0.1057 0.8409 0.9081
0.0553 0.4195 0.7629
0.0645 0.6662 1
0.3616 0.8494 1
0.0612 0.33 0.7217
0.0281 0.8471 1
0.0793 0.3021 0.6891
0.1552 0.8503 1
0.0326 0.8258 1
0.1059 0.8258 1
0.1209 0.8499 1
0.155 0.8376 0.895
0.0055 0.7073 0.6476
0.2527 0.85 1
0.0055 0.8246 0.8668
0.0521 0.8469 1
0.0741 0.8258 1
0.1298 0.7615 1
0.0333 0.4586 0.4439
0.023 0.8258 1
0.0245 0.2636 0.7477
0.0095 0.3011 1
0.0055 0.8246 1
0.0055 0.8246 0.8668
0.0055 0.8246 1
0.0407 0.8246 1
0.0302 0.8246 1
0.1633 0.8451 1
0.0055 0.8246 0.8668
0.0055 0.8246 0.8668
0.0241 0.4759 0.9493
0.0528 0.6248 1
0.1069 0.8258 1
0.136 0.8241 0.9006
0.1274 0.8511 1
0.144 0.8502 1
0.1842 0.8508 1
0.2014 0.6636 1
0.1021 0.8258 1
0.0055 0.8246 1
0.1336 0.8412 0.9005
0.393 0.8498 1
0.0293 0.3718 1
0.1344 0.8513 1
0.18 0.8258 1
0.0055 0.8246 1
0.4528 0.8258 1
0.0055 0.365 1
0.0793 0.4894 0.6469
0.1037 0.3012 0.8236
0.0237 0.8439 1
0.0598 0.5092 0.6637
0.0055 0.8246 1
0.1154 0.8509 0.8875
0.0918 0.5988 1
0.0335225 0.293039 0.293039
0.0081 0.5 0.5
0.1227 0.8294 0.9034
0.0055 0.8246 1
0.1131 0.6571 1
0.0789 0.4694 0.6753
0.0519 0.8469 1
0.3616 0.8494 1
0.0758 0.7782 1
0.1112 0.8506 1
0.0026 0.5 0.5
0.0029 0.5 0.5
0.0521 0.8485 1
0.44 0.8473 1
0.099 0.3913 0.7515
0.2327 0.8479 1
0.0785 0.6073 0.6682
0.0599 0.2515 0.438
0.0931 0.8508 1
0.0056 1 0.5
0.2895 0.8503 1
0.0853 0.8258 1
0.0092 1 0.5
0.117 0.8246 0.9034
0.0055 0.8246 1
0.077 0.3402 0.5641
0.0718 0.6731 1
0.319 0.8438 1
0.0954 0.5411 1
0.0982 0.7966 0.2774
0.0055 0.8246 0.8668
0.1661 0.848 0.8944
0.0045 0.2945 1
0.0607 0.3916 0.7253
0.0143 0.2747 0.6507
0.0744 0.2709 0.6769
0.0335225 0.293039 0.293039
0.0187 0.5857 0.8208
0.0008 0.5 0.5
0.1302 0.8258 1
0.0046 0.8246 1
0.0107 0.3311 0.4334
0.3922 0.8261 1
0.0055 0.7259 1
0.0088 0.4477 0.5
0.0055 0.2539 0.5674
0.0282 0.8407 1
0.0301 0.2818 0.6737
0.5084 0.838 1
0.0656 0.8492 1
0.0675 0.5891 1
0.0251 0.3453 1
0.0055 0.8246 1
0.0066 0.3101 0
0.0785 0.3135 0.7091
0.0098 0.3242 0.3167
0.0931 0.8508 1
0.0247 0.2986 1
0.0786 0.5978 0.6713
0.0733 0.4326 1
0.1411 0.8506 1
0.1612 0.8421 0.8951
0.1345 0.8508 1
0.0055 0.8246 1
0.0055 0.8246 1
0.0521 0.8469 1
0.0804 0.8258 1
0.0298 0.2837 0.6969
0.0686 0.4629 1
0.0012 0.5 0.5
0.1026 0.7083 1
0.16 0.8258 1
0.0751 0.356 0.9826
0.0585 0.3649 1
0.0063 0.7244 0
0.0055 0.8246 1
0.0201 0.4193 1
0.1666 0.8495 1
0.0055 0.8246 0.8668
0.0055 0.8246 0.8668
0.0365 0.847 1
0.0061 0.6883 0.6247
0.0843 0.8258 1
0.0367 0.8258 1
0.0184 0.8258 1
0.0699 0.7558 1
0.0932 0.2836 0.671
0.0047 0.8246 0.8668
0.0646 0.3177 0.6997
0.0513 0.8258 1
0.0694 0.2834 0.7337
0.1166 0.3876 0.7735
0.0532 0.8446 1
0.0585 0.3649 1
0.0233 0.254 1
0.0138 0.2866 0.6788
0.0039 0.9485 0.5
0.2678 0.8451 1
0.0007 0.5 0.5
0.2338 0.8498 1
0.0455 0.8258 1
0.0307 0.2748 1
0.1302 0.8258 1
0.0205 0.8246 1
0.1336 0.8412 0.9005
0.1917 0.5958 1
0.1539 0.4552 0.8841
0.0138 0.3395 0.2685
0.1431 0.8246 0.8947
0.0722 0.8227 1
0.1216 0.8457 1
0.0464 0.8246 1
0.0055 0.8246 0.8668
0.4618 0.8492 1
0.0055 0.8258 1
0.0981 0.8258 1
0.0055 0.8246 1
0.0055 0.3797 1
0.3724 0.8511 1
0.015 0.2539 0.5674
0.0055 0.8246 1
0.0332 0.501 1
0.0153 0.3736 1
0.104 0.4286 1
0.0016 0.5 0.5
0.1256 0.8399 0.9006
0.1098 0.325 0.9828
0.0278 0.8369 1
0.0048 0.319 0.3205
0.1758 0.8449 1
0.069 0.8489 1
0.1079 0.8258 1
0.0842 0.3931 0.5674
0.0754 0.4956 0.663
0.0775 0.4104 0.8215
0.0931 0.8508 1
0.0249 0.2932 0.6778
0.0055 0.761 1
0.0063 1 1
0.0931 0.8508 1
0.0055 0.8246 1
0.0553 0.4195 0.7629
0.0088 0.8417 1
0.0055 0.8246 1
0.1949 0.8258 1
0.0741 0.6381 0.7031
0.0733 0.4326 1
0.0055 0.8246 1
0.3616 0.8494 1
0.1099 0.2595 1
0.0951 0.4492 0.8396
0.0871 0.4246 0.8087
0.0155 0.2867 0.3389
0.0788 0.4844 0.644
0.0055 0.8246 0.8668
0.2543 0.4433 1
0.0574 0.2779 0.6498
0.1021 0.8487 1
0.0758 0.7782 1
0.3455 0.8346 1
0.0055 0.8246 1
0.0104 0.588 1
0.0044 0.2507 0
0.1305 0.4867 0.9025
0.0023 0.5 0.5
0.0373 0.2871 0.454
0.0815 0.4951 0.65
0.0055 0.8246 1
0.0767 0.5845 0.673
0.0055 0.8246 1
0.0751 0.4704 0.6357
0.3721 0.8509 1
0.0328 0.8268 1
0.2616 0.8504 1
0.0606 0.8482 1
0.2464 0.8478 1
0.1114 0.65 1
0.1299 0.8498 1
0.0055 0.8246 1
0.1154 0.8246 0.9017
0.0153 0.4445 0.9462
0.2317 0.8506 1
0.159 0.848 0.8968
0.0798 0.5857 1
0.0553 0.4195 0.7629
0.0551 0.8246 1
0.061 0.8246 1
0.0055 0.2539 0.5674
0.0428 0.8315 1
0.1069 0.8258 1
0.037 0.5378 1
0.0968 0.5299 1
0.0842 0.3931 0.5674
0.0055 0.8246 1
0.0201 0.4193 1
0.0333 0.4586 0.4439
0.0183 0.8446 1
0.074 0.8287 1
0.0055 0.8246 1
0.0004 0.5 0.5
0.0283 0.328 0.8147
0.0056 0.3025 0.2774
0.0055 0.8246 1
0.1241 0.8505 1
0.0055 0.8246 0.8668
0.0049 0.3406 0.3424
0.1483 0.8258 1
0.0362 0.307 0.5742
0.0486 0.827 1
0.0789 0.4694 0.6753
0.0047 0.5197 0.523
0.1539 0.4552 0.8841
0.024 0.8258 1
0.0088 0.8417 1
0.0931 0.8508 1
0.0155 0.2867 0.3389
0.0091 1 0.5
0.0055 0.3893 0.5
0.0055 0.8246 0.8668
0.0779 0.85 1
0.2338 0.8498 1
0.4618 0.8492 1
0.0659 0.4532 1
0.0231 0.3052 0.698
0.0775 0.4104 0.8215
0.0281 0.2887 1
0.0894 0.275 0.3975
0.1597 0.8434 1
0.1035 0.8508 1
0.2338 0.8498 1
0.3687 0.8263 1
0.1095 0.635 1
0.0055 0.8258 1
0.0187 0.3795 1
0.0751 0.4983 0.6656
0.0055 0.8246 0.8668
0.0141304 0.277627 1
0.0093 0.8828 0
0.0431 0.8258 1
0.0064 0.3377 0.8757
0.1299 0.8498 1
0.0416 0.3116 0.692
0.0244 0.2724 0.6719
0.0288 0.8258 1
0.398 0.8508 1
0.0055 0.8246 1
0.5084 0.838 1
0.0155 0.2867 0.3389
0.0055 0.8246 1
0.0055 0.8246 1
0.1011 0.453 1
0.0055 0.8246 1
0.0584 0.8471 1
0.0055 0.8246 0.8668
0.0734 0.3587 0.8593
0.0055 0.8246 1
0.0607 0.3916 0.7253
0.0607 0.8353 0.865
0.1267 0.4489 0.841
0.0314 0.8246 1
0.0055 0.8246 1
0.0841 0.8493 1
0.0055 0.2539 0.5674
0.0882 0.8503 1
0.0055 0.8246 0.8668
0.0044 0.7293 1
0.0055 0.8246 0.8668
0.104 0.4286 1
0.2092 0.8258 1
0.0333 0.4586 0.4439
0.1097 0.8502 1
0.0055 0.2539 0.5674
0.0055 0.2539 0.5674
0.1026 0.7083 1
0.1084 0.6602 1
0.0553 0.8258 1
0.0042 0.5 0.5
0.0044 0.5689 1
0.2014 0.6636 1
0.4339 0.8501 1
0.0697 0.5802 1
0.0566 0.844 1
0.1298 0.7615 1
0.0361 0.8366 1
0.0097 0.298 1
0.1466 0.8258 1
0.0055 0.8246 0.8668
0.4479 0.8508 1
0.0699 0.7558 1
0.0932 0.2836 0.671
0.3334 0.8497 1
0.0813 0.615 0.6775
0.0931 0.8508 1
0.0692 0.8246 0.9274
0.0059 0.7959 0.5
0.0055 0.8246 0.8668
0.0055 0.8246 0.8668
0.019 0.8246 1
0.0109 0.2639 0.2601
0.0931 0.8508 1
0.0044 0.2636 1
0.0055 0.8246 0.8668
0.0155 0.2867 0.3389
0.0055 0.8246 1
0.4445 0.8511 1
0.0527 0.8434 1
0.0096 0.8258 1
0.0749 0.3792 0.6504
0.0094 0.7235 1
0.1105 0.8497 1
0.0655 0.3334 0.7298
0.0055 0.8246 0.8668
0.0995 0.8258 1
0.1806 0.8495 1
0.0302 0.8246 1
0.0302 0.4269 1
0.0046 0.8231 1
0.1559 0.8258 1
0.0233 0.254 1
0.0044 0.7418 1
0.0069 0.3067 0.5
0.0719 0.8258 1
0.1211 0.85 0.9016
0.0289 0.318 1
0.0606 0.6566 1
0.0841 0.8258 1
0.0718 0.6731 1
0.0415 0.8258 1
0.16 0.8258 1
0.0155 0.2867 0.3389
0.1274 0.8511 1
0.0055 0.8246 1
0.0055 0.8246 0.8668
0.0158 0.3281 0.3184
0.0481 0.4414 0.8435
0.0232 0.2822 0.6742
0.0926 0.447 0.787
0.1243 0.8259 1
0.0044 0.2507 0
0.1098 0.325 0.9828
0.1002 0.8149 1
0.3417 0.8514 1
0.4611 0.8513 1
0.1364 0.8452 1
0.2543 0.4433 1
0.3015 0.851 1
0.0204 0.8361 1
0.061 0.8246 1
0.0422 0.8258 1
0.2611 0.2502 1
0.4035 0.8515 1
0.0055 0.8246 1
0.0201 0.4193 1
0.0553 0.4195 0.7629
0.0249 0.2932 0.6778
0.0779 0.85 1
0.1719 0.8258 1
0.0528 0.4467 1
0.023 0.2695 0.6778
0.057 0.5101 1
0.0779 0.8089 0.5
0.1007 0.8505 1
0.0559 0.3695 0.7719
0.0426 0.7536 1
0.0499 0.364 1
0.0556 0.8229 0.2774
0.0327 0.8258 1
0.3655 0.8508 1
0.0246 0.3019 0.4485
0.1295 0.75 1
0.079 0.4996 0.6425
0.0103 0.5787 1
0.0678 0.8258 1
0.0055 0.8246 0.8668
0.0206 0.2826 0.5017
0.0907 0.7187 1
0.1712 0.8258 1
0.0606 0.8482 1
0.2001 0.8258 1
0.0055 0.8246 1
0.0256 0.2644 0.2644
0.0285 0.3792 0.4713
0.1612 0.8246 0.895
0.0052 0.8246 1
0.0055 0.343 1
0.0528 0.6248 1
0.0745 0.8258 1
0.0857 0.849 1
0.1155 0.3925 1
0.0736 0.3056 0.6973
0.4101 0.8258 1
0.0954 0.5568 1
0.0768 0.8507 1
0.4389 0.851 1
0.0274 0.8258 1
0.0055 0.2582 0.8668
0.0044 0.5689 1
0.0055 0.2656 1
0.0055 0.8246 0.8666
0.1608 0.8258 1
0.0055 0.8246 0.8668
0.1962 0.8505 1
0.0018 0.5 0.5
0.077 0.6077 0.6749
0.3892 0.8513 1
0.0566 0.8258 1
0.0519 0.3844 0.8531
0.0202 0.3806 1
0.1184 0.4372 0.828
0.0037 1 0.5
0.0055 0.8246 1
0.0804 0.8258 1
0.1831 0.8258 1
0.1066 0.3398 0.728
0.1142 0.7036 1
0.1209 0.8499 1
0.0135 0.3757 1
0.0416 0.3116 0.692
0.2737 0.7481 1
0.4915 0.8515 1
0.1154 0.8509 0.8875
0.0495 0.8511 1
0.0055 0.8246 0.8668
0.1271 0.8454 1
0.1154 0.8509 0.8875
0.0055 0.8246 1
0.0055 0.8246 1
0.0786 0.3676 0.7564
0.0298 0.3106 0.7033
0.0431 0.8495 1
0.0056 0.3146 0.8719
0.1295 0.75 1
0.108 0.4892 1
0.3687 0.8263 1
0.0714 0.4863 1
0.0032 0.5 0.5
0.0647 0.8258 1
0.0055 0.2539 0.5674
0.02 0.8258 1
0.0155 0.2867 0.3389
0.116 0.8503 1
0.3991 0.5098 1
0.0444 0.3524 0.559
0.0481 0.4414 0.8435
0.0045 0.3179 0.3203
0.0055 0.8246 1
0.288 0.8509 1
0.0055 0.8246 1
0.0201 0.7274 0.7198
0.0803 0.3543 1
0.1173 0.3573 0.7969
0.0331 0.8246 1
0.0251 0.3453 1
0.0055 0.8246 1
0.0438 0.8196 0.5
0.0055 0.8246 0.8668
0.0138 0.2539 0.5674
0.0055 0.2539 0.5674
0.1154 0.8509 0.8875
0.0612 0.33 0.7217
0.0233 0.254 1
0.2592 0.8037 1
0.0007 0.5 0.5
0.0751 0.356 0.9826
0.0055 0.8246 1
0.009 0.3204 1
0.0519 0.8258 1
0.0059 1 1
0.0044 0.2507 0
0.1586 0.8513 1
0.0744 0.8497 1
0.0249 0.2539 0.5674
0.1309 0.8507 1
0.0096 0.8258 1
0.0055 0.8246 0.8668
0.0003 0.5 0.5
0.0055 0.8246 1
0.0321 0.8258 1
0.4422 0.8464 1
0.1758 0.8449 1
0.0763 0.6397 0.6749
0.0067 0.5 0.5
0.005 0.2633 1
0.0055 0.8246 0.8668
0.0609 0.5422 1
0.0152 0.4784 1
0.0927 0.5133 1
0.1251 0.8341 1
0.0561 0.6686 0.887
0.0517 0.8276 0.9507
0.141 0.8416 1
0.0845 0.8246 0.8668
0.1256 0.8399 0.9006
0.0523 0.6654 1
0.3667 0.8246 1
0.0481 0.4414 0.8435
0.4121 0.8258 1
0.1211 0.85 0.9016
0.21 0.8258 1
0.0155 0.2867 0.3389
0.21 0.8258 1
0.0055 0.8246 1
0.0055 0.8246 1
0.0553 0.4195 0.7629
0.048 0.315 0.7424
0.0055 0.2539 0.5674
0.0055 0.8246 1
0.0847 0.3412 0.5421
0.0697 0.2726 0.6822
0.0585 0.3649 1
0.0055 0.8246 0.8668
0.1392 0.3868 1
0.0055 0.8246 0.8668
0.0907 0.7187 1
0.0364 0.8258 1
0.0652 0.8258 1
0.1606 0.8258 1
0.038 0.3189 0.3183
0.0385 0.6397 1
0.0846 0.8487 1
0.0055 0.7239 1
0.1251 0.8246 0.901
0.3724 0.8511 1
0.3892 0.8513 1
0.4345 0.8508 1
0.0055 0.8246 0.8668
0.0059 1 1
0.0055 0.8246 0.8668
0.0978 0.8258 1
0.1025 0.4981 1
0.0483 0.8246 1
0.0055 0.8246 1
0.0049 0.3416 0.3435
0.4061 0.8512 1
0.0055 0.8246 0.8668
0.0754 0.63 0.6717
0.0055 0.8246 1
0.1295 0.75 1
0.1312 0.8246 0.8972
0.0307 0.2748 1
0.1432 0.8396 0.9048
0.0947 0.6173 1
0.0055 0.8246 1
0.0057 0.2544 0.9346
0.0055 0.8246 1
0.0108 0.3273 0.4334
0.0055 0.4793 0.3355
0.0045 0.8041 0.8315
0.0228 0.8456 1
0.4958 0.8504 1
0.0198 0.4407 1
0.0863 0.8258 1

Assayability

Assay information

No assay information for this target.

Reagent availability

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Bibliographic References

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Gene identifier EHI_108670 (Entamoeba histolytica), protein kinase domain containing protein
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