pI: 7.6183 |
Length (AA): 391 |
MW (Da): 44211 |
Paralog Number:
0
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 3 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
1 | 44 | 3ljc (A) | 200 | 243 | 20.00 | 0.24 | 0.01 | 0.436732 | -1.46 |
2 | 388 | 5c19 (D) | 352 | 757 | 31.00 | 0.000017 | 1 | 1.26397 | 0.63 |
123 | 383 | 3h4m (A) | 158 | 418 | 57.00 | 0 | 1 | 1.44142 | -1.11 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Upper 60-80% percentile | Trophozoite, Rahman HM-1 IMSS Trophozoite. | Hon CC |
Hon CC | Transcriptomics of virulent and avirulent strains |
Ortholog group members (OG5_127828)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT5G43010 | 26S proteasome AAA-ATPase subunit RPT4a |
Babesia bovis | BBOV_II003900 | 26S proteasome AAA-ATPase subunit RPT4a, putative |
Brugia malayi | Bm1_31980 | Probable 26S protease regulatory subunit S10B |
Candida albicans | CaO19.482 | likely ATPase similar to S. cerevisiae RPT4 (YOR259C) ATPase subunit of the 19S regulatory particle of the 26S proteasome |
Candida albicans | CaO19.8112 | likely ATPase similar to S. cerevisiae RPT4 (YOR259C) ATPase subunit of the 19S regulatory particle of the 26S proteasome |
Caenorhabditis elegans | CELE_F23F1.8 | Protein RPT-4, isoform B |
Cryptosporidium hominis | Chro.80103 | 26S proteasome regulatory subunit |
Cryptosporidium parvum | cgd8_840 | 26S proteasome regulatory subunit S10b like AAA+ ATpase |
Dictyostelium discoideum | DDB_G0284517 | 26S protease regulatory subunit S10B |
Drosophila melanogaster | Dmel_CG7257 | Regulatory particle triple-A ATPase 4-related |
Drosophila melanogaster | Dmel_CG3455 | Regulatory particle triple-A ATPase 4 |
Echinococcus granulosus | EgrG_000440700 | 26s protease regulatory subunit s10b |
Entamoeba histolytica | EHI_194570 | 26S protease regulatory subunit, putative |
Echinococcus multilocularis | EmuJ_000440700 | 26s protease regulatory subunit s10b |
Giardia lamblia | GL50803_21331 | 26S protease regulatory subunit 7 |
Homo sapiens | ENSG00000100519 | proteasome (prosome, macropain) 26S subunit, ATPase, 6 |
Leishmania braziliensis | LbrM.03.0450 | 26S protease regulatory subunit, putative,serine peptidase, Clan SJ, family S16, putative |
Leishmania donovani | LdBPK_030520.1 | 26S protease regulatory subunit, putative |
Leishmania infantum | LinJ.03.0520 | 26S protease regulatory subunit, putative,serine peptidase, Clan SJ, family S16, putative |
Leishmania major | LmjF.03.0540 | 26S protease regulatory subunit, putative,serine peptidase, Clan SJ, family S16, putative |
Leishmania mexicana | LmxM.03.0540 | 26S protease regulatory subunit, putative,serine peptidase, Clan SJ, family S16, putative |
Loa Loa (eye worm) | LOAG_01658 | hypothetical protein |
Loa Loa (eye worm) | LOAG_01659 | proteasome 26S subunit |
Mus musculus | ENSMUSG00000021832 | proteasome (prosome, macropain) 26S subunit, ATPase, 6 |
Neospora caninum | NCLIV_045220 | hypothetical protein |
Oryza sativa | 4341487 | Os06g0607800 |
Oryza sativa | 4328642 | Os02g0199900 |
Plasmodium berghei | PBANKA_1404900 | 26S protease regulatory subunit 10B, putative |
Plasmodium falciparum | PF3D7_1306400 | 26S protease regulatory subunit 10B, putative |
Plasmodium knowlesi | PKNH_1406600 | 26S protease regulatory subunit 10B, putative |
Plasmodium vivax | PVX_122155 | 26S protease regulatory subunit 10B, putative |
Plasmodium yoelii | PY02590 | 26s protease regulatory subunit s10b (p44) (conserved atpase domain protein 44). [thirteen-lined ground squirrel] |
Saccharomyces cerevisiae | YOR259C | proteasome regulatory particle base subunit RPT4 |
Schistosoma japonicum | Sjp_0072420 | ko:K03064 26S proteasome regulatory subunit T4, putative |
Schistosoma mansoni | Smp_017070 | 26S protease regulatory subunit S10b |
Schmidtea mediterranea | mk4.005974.00 | |
Schmidtea mediterranea | mk4.046932.01 | Probable 26S protease regulatory subunit 10B |
Schmidtea mediterranea | mk4.003129.03 | Probable 26S protease regulatory subunit 10B |
Schmidtea mediterranea | mk4.002912.01 | Probable 26S protease regulatory subunit 10B |
Schmidtea mediterranea | mk4.003008.06 | Probable 26S protease regulatory subunit 10B |
Schmidtea mediterranea | mk4.001038.02 | Probable 26S protease regulatory subunit 10B |
Schmidtea mediterranea | mk4.000012.02 | Probable 26S protease regulatory subunit 10B |
Schmidtea mediterranea | mk4.006062.00 | Probable 26S protease regulatory subunit 10B |
Schmidtea mediterranea | mk4.002773.04 | Probable 26S protease regulatory subunit 10B |
Schmidtea mediterranea | mk4.013876.00 | Probable 26S protease regulatory subunit 10B |
Schmidtea mediterranea | mk4.002912.00 | |
Schmidtea mediterranea | mk4.012190.01 | Probable 26S protease regulatory subunit 10B |
Schmidtea mediterranea | mk4.001647.01 | Probable 26S protease regulatory subunit 10B |
Trypanosoma brucei gambiense | Tbg972.10.4380 | Tbgamb.27571 protease regulatory ATPase subunit, putative |
Trypanosoma brucei | Tb927.10.3520 | protease regulatory ATPase subunit 4 |
Trypanosoma congolense | TcIL3000_10_2910 | serine peptidase, Clan SJ, family S16, putative |
Trypanosoma cruzi | TcCLB.510311.70 | 26S protease regulatory subunit, putative |
Trypanosoma cruzi | TcCLB.510265.20 | serine peptidase, Clan SJ, family S16, putative |
Toxoplasma gondii | TGME49_228210 | 26S proteasome regulatory subunit |
Theileria parva | TP04_0152 | 26S proteasome regulatory subunit, putative |
Trichomonas vaginalis | TVAG_115420 | 26S protease regulatory subunit, putative |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
Tb927.10.3520 | Trypanosoma brucei | no significant loss or gain of fitness in bloodstream forms (3 days) | alsford |
Tb927.10.3520 | Trypanosoma brucei | significant loss of fitness in bloodstream forms (6 days) | alsford |
Tb927.10.3520 | Trypanosoma brucei | significant loss of fitness in procyclic forms | alsford |
Tb927.10.3520 | Trypanosoma brucei | no significant loss or gain of fitness in differentiation of procyclic to bloodstream forms | alsford |
CELE_F23F1.8 | Caenorhabditis elegans | embryonic arrest | wormbase |
CELE_F23F1.8 | Caenorhabditis elegans | embryonic lethal | wormbase |
CELE_F23F1.8 | Caenorhabditis elegans | larval lethal | wormbase |
CELE_F23F1.8 | Caenorhabditis elegans | slow growth | wormbase |
CELE_F23F1.8 | Caenorhabditis elegans | sterile | wormbase |
YOR259C | Saccharomyces cerevisiae | inviable | yeastgenome |
PBANKA_1404900 | Plasmodium berghei | Essential | plasmo |
TGME49_228210 | Toxoplasma gondii | Probably essential | sidik |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
Species | Known druggable target | Linked compounds | Reference |
---|---|---|---|
Homo sapiens | proteasome (prosome, macropain) 26S subunit, ATPase, 6 | Compounds | References |