Detailed view for EHI_040840

Basic information

TDR Targets ID: 798399
Entamoeba histolytica, dephospho-CoA kinase, putative
Source Database / ID:  AmoebaDB  

pI: 8.6992 | Length (AA): 206 | MW (Da): 23903 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF01121   Dephospho-CoA kinase

Gene Ontology

Mouse over links to read term descriptions.
GO:0004140   dephospho-CoA kinase activity  
GO:0005524   ATP binding  
GO:0015937   coenzyme A biosynthetic process  

Metabolic Pathways

Pantothenate and CoA biosynthesis (KEGG)
Global map (KEGG)

Structural information

Modbase 3D models:

There are 5 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
1 205 4zo4 (A) 1 200 25.00 0 1 1.32135 -0.45
2 192 2f6r (A) 61 249 25.00 0 1 1.33538 -1.03
3 192 2grj (A) 0 167 33.00 0 1 1.23653 -0.48
5 201 2f6r (A) 64 261 22.00 0.00042 1 1.35931 -0.93
5 205 1jjv (A) 3 204 25.00 0 1 1.28693 -0.81

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

Upregulation Percent Ranking Stage Dataset
Mid 40-60% percentile Trophozoite, Rahman HM-1 IMSS Trophozoite. Hon CC
Show/Hide expression data references
  • Hon CC Transcriptomics of virulent and avirulent strains

Orthologs

Ortholog group members (OG5_127254)

Species Accession Gene Product
Arabidopsis thaliana AT2G27490   dephospho-CoA kinase
Babesia bovis BBOV_IV009580   dephospho-CoA kinase, putative
Brugia malayi Bm1_18905   dephospho-CoA kinase family protein
Candida albicans CaO19.11488   similar to S. cerevisiae YDR196C
Candida albicans CaO19.4005   similar to S. cerevisiae YDR196C
Caenorhabditis elegans CELE_T05G5.5   Protein T05G5.5, isoform C
Cryptosporidium hominis Chro.20045   COG0237: dephospho-CoA kinase
Cryptosporidium parvum cgd2_380   COG0237: dephospho-CoA kinase
Chlamydia trachomatis CT_492   dephospho-CoA kinase
Dictyostelium discoideum DDB_G0285525   dephospho-CoA kinase
Drosophila melanogaster Dmel_CG1939   Dephospho-CoA kinase
Escherichia coli b0103   dephospho-CoA kinase
Entamoeba histolytica EHI_040840   dephospho-CoA kinase, putative
Echinococcus multilocularis EmuJ_000154100   dephospho-CoA kinase, putative
Giardia lamblia GL50803_16483   Dephospho-CoA kinase
Homo sapiens ENSG00000172992   dephospho-CoA kinase domain containing
Leishmania braziliensis LbrM.22.1430   dephospho-CoA kinase, putative
Leishmania donovani LdBPK_221380.1   dephospho-CoA kinase, putative
Leishmania infantum LinJ.22.1380   dephospho-CoA kinase, putative
Leishmania major LmjF.22.1530   dephospho-CoA kinase, putative
Leishmania mexicana LmxM.22.1530   dephospho-CoA kinase, putative
Loa Loa (eye worm) LOAG_07853   dephospho-CoA kinase
Mycobacterium leprae ML1383   Probable dephospho-CoA kinase CoaE (dephosphocoenzyme A kinase)
Mus musculus ENSMUSG00000020935   dephospho-CoA kinase domain containing
Mycobacterium tuberculosis Rv1631   Probable dephospho-CoA kinase CoaE (dephosphocoenzyme a kinase)
Mycobacterium ulcerans MUL_1613   dephospho-CoA kinase/protein folding accessory domain-containing protein
Oryza sativa 4326028   Os01g0360600
Plasmodium berghei PBANKA_1307600   dephospho-CoA kinase, putative
Plasmodium falciparum PF3D7_1443700   dephospho-CoA kinase, putative
Plasmodium knowlesi PKNH_1238600   dephospho-CoA kinase, putative
Plasmodium vivax PVX_118305   dephospho-CoA kinase, putative
Plasmodium yoelii PY01909   dephospho-CoA kinase, putative
Saccharomyces cerevisiae YDR196C   putative dephospho-CoA kinase
Trypanosoma brucei gambiense Tbg972.6.400   dephospho-CoA kinase, putative
Trypanosoma brucei Tb927.6.710   dephospho-CoA kinase, putative
Trypanosoma congolense TcIL3000_6_260   dephospho-CoA kinase, putative
Trypanosoma cruzi TcCLB.511825.210   dephospho-CoA kinase, putative
Treponema pallidum TP0296   hypothetical protein
Theileria parva TP01_0811   dephospho-CoA kinase, putative
Trichomonas vaginalis TVAG_083610   Dephospho-CoA kinase, putative
Wolbachia endosymbiont of Brugia malayi Wbm0259   dephospho-CoA kinase

Essentiality

EHI_040840 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
mtu1659 Mycobacterium tuberculosis essential nmpdr
Tb927.6.710 Trypanosoma brucei significant loss of fitness in bloodstream forms (3 days) alsford
Tb927.6.710 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (6 days) alsford
Tb927.6.710 Trypanosoma brucei significant loss of fitness in procyclic forms alsford
Tb927.6.710 Trypanosoma brucei significant loss of fitness in differentiation of procyclic to bloodstream forms alsford
b0103 Escherichia coli essential goodall
YDR196C Saccharomyces cerevisiae inviable yeastgenome
PBANKA_1307600 Plasmodium berghei Essential plasmo
Show/Hide essentiality data references
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

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User comments

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Gene identifier EHI_040840 (Entamoeba histolytica), dephospho-CoA kinase, putative
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