pI: 5.1568 |
Length (AA): 293 |
MW (Da): 33520 |
Paralog Number:
0
Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 7
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There is 1 model calculated for this protein. More info on
this model, including the
model itself is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
222 | 255 | 3bog (C) | 3 | 69 | 99.99 | 0 | 0 | 1.13014 | -0.2 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Upper 60-80% percentile | Rahman HM-1 IMSS Trophozoite. | Hon CC |
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Mid 40-60% percentile | Trophozoite. | Hon CC |
Hon CC | Transcriptomics of virulent and avirulent strains |
Ortholog group members (OG5_128704)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT2G34980 | phosphatidylinositol glycan, class C |
Babesia bovis | BBOV_IV011600 | hypothetical protein |
Brugia malayi | Bm1_32160 | hypothetical protein |
Candida albicans | CaO19.538 | synthesis of GlcNAc phosphotidylinositol |
Candida albicans | CaO19.8171 | synthesis of GlcNAc phosphotidylinositol |
Caenorhabditis elegans | CELE_T20D3.8 | Protein T20D3.8 |
Cryptosporidium hominis | Chro.10380 | phosphatidylinositol-glycan-class c |
Cryptosporidium parvum | cgd1_3380 | phosphatidylinositol-glycan-class c, pigC, 8x transmembrane domains |
Dictyostelium discoideum | DDB_G0286221 | GlcNAc transferase |
Drosophila melanogaster | Dmel_CG12077 | Phosphatidylinositol glycan anchor biosynthesis, class C ortholog (H. sapiens) |
Echinococcus granulosus | EgrG_001029700 | phosphatidylinositol |
Entamoeba histolytica | EHI_031520 | phosphatidylinositol N-acetylglucosaminyltransferase subunit C, putative |
Echinococcus multilocularis | EmuJ_001029700 | phosphatidylinositol |
Homo sapiens | ENSG00000135845 | phosphatidylinositol glycan anchor biosynthesis, class C |
Leishmania braziliensis | LbrM.35.1900 | phosphatidylinositolN-acetylglucosaminyltransfe ra sesubunit c, putative |
Leishmania donovani | LdBPK_361790.1 | phosphatidylinositolN-acetylglucosaminyltransfe ra sesubunit c, putative |
Leishmania infantum | LinJ.36.1790 | phosphatidylinositolN-acetylglucosaminyltransfe ra sesubunit c, putative |
Leishmania major | LmjF.36.1710 | phosphatidylinositolN-acetylglucosaminyltransfe ra sesubunit c, putative |
Leishmania mexicana | LmxM.36.1710 | phosphatidylinositolN-acetylglucosaminyltransfe ra sesubunit c, putative |
Loa Loa (eye worm) | LOAG_02980 | hypothetical protein |
Mus musculus | ENSMUSG00000026698 | phosphatidylinositol glycan anchor biosynthesis, class C |
Neospora caninum | NCLIV_009460 | phosphatidylinositol N- acetylglucosaminyltransferase subunit, putative |
Oryza sativa | 4330019 | Os02g0622200 |
Plasmodium berghei | PBANKA_0812100 | phosphatidylinositol N-acetylglucosaminyltransferase, putative |
Plasmodium falciparum | PF3D7_0911000 | phosphatidylinositol N-acetylglucosaminyltransferase, putative |
Plasmodium knowlesi | PKNH_0709000 | phosphatidylinositol N-acetylglucosaminyltransferase, putative |
Plasmodium vivax | PVX_098990 | phosphatidylinositol N-acetylglucosaminyltransferase, putative |
Saccharomyces cerevisiae | YPL076W | Gpi2p |
Schistosoma japonicum | Sjp_0216060 | ko:K03859 phosphatidylinositol glycan, class C, putative |
Schmidtea mediterranea | mk4.001621.07 | |
Trypanosoma brucei gambiense | Tbg972.10.7510 | phosphatidylinositolN- acetylglucosaminyltransferase subunit c, putative |
Trypanosoma brucei | Tb11.v5.0206 | phosphatidylinositolN-acetylglucosaminyltransferase, putative |
Trypanosoma congolense | TcIL3000_10_5190 | phosphatidylinositolN- acetylglucosaminyltransferase subunit c, putative |
Trypanosoma cruzi | TcCLB.503781.20 | phosphatidylinositol N-acetylglucosaminyltransferase subunit C, putative |
Trypanosoma cruzi | TcCLB.507639.100 | phosphatidylinositol N-acetylglucosaminyltransferase subunit C, putative |
Toxoplasma gondii | TGME49_299040 | phosphatidylinositol n-acetylglucosaminyltransferase |
Theileria parva | TP01_1147 | hypothetical protein |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
Tb927.10.6140 | Trypanosoma brucei | no significant loss or gain of fitness in bloodstream forms (3 days) | alsford |
Tb927.10.6140 | Trypanosoma brucei | no significant loss or gain of fitness in bloodstream forms (6 days) | alsford |
Tb927.10.6140 | Trypanosoma brucei | significant loss of fitness in procyclic forms | alsford |
Tb927.10.6140 | Trypanosoma brucei | no significant loss or gain of fitness in differentiation of procyclic to bloodstream forms | alsford |
YPL076W | Saccharomyces cerevisiae | inviable | yeastgenome |
PBANKA_0812100 | Plasmodium berghei | Essential | plasmo |
TGME49_299040 | Toxoplasma gondii | Probably essential | sidik |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.