Detailed view for EHI_012420

Basic information

TDR Targets ID: 801300
Entamoeba histolytica, myb-like DNA-binding domain containing protein

Source Database / ID:  AmoebaDB  

pI: 9.6674 | Length (AA): 168 | MW (Da): 19748 | Paralog Number: 4

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00249   Myb-like DNA-binding domain

Gene Ontology

Mouse over links to read term descriptions.
GO:0003677   DNA binding  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

No model available for this protein in Modbase.

PDB Structures:

No structure availble in the PDB for this protein

Expression

Upregulation Percent Ranking Stage Dataset
Upper 80-100% percentile Trophozoite, Rahman HM-1 IMSS Trophozoite. Hon CC
Show/Hide expression data references
  • Hon CC Transcriptomics of virulent and avirulent strains

Orthologs

Ortholog group members (OG5_127030)

Species Accession Gene Product
Arabidopsis thaliana AT5G11510   putative c-myb-like transcription factor MYB3R-4
Arabidopsis thaliana AT4G32730   myb-related protein 3R-1
Arabidopsis thaliana AT3G09370   c-myb-like transcription factor MYB3R3
Arabidopsis thaliana AT5G02320   myb domain protein 3r-5
Candida albicans CaO19.6874   transcriptional activator of ade/his synthesis
Candida albicans CaO19.3809   regulates histidine and adenine biosynthesis
Candida albicans CaO19.14163   transcriptional activator of ade/his synthesis
Candida albicans CaO19.11290   regulates histidine and adenine biosynthesis
Dictyostelium discoideum DDB_G0293900   myb domain-containing protein
Drosophila melanogaster Dmel_CG9045   Myb oncogene-like
Entamoeba histolytica EHI_012420   myb-like DNA-binding domain containing protein
Entamoeba histolytica EHI_153360   myb-like DNA-binding domain containing protein
Entamoeba histolytica EHI_063550   myb-like DNA-binding domain containing protein
Entamoeba histolytica EHI_098070   myb-like DNA-binding domain containing protein
Entamoeba histolytica EHI_166410   myb-like DNA-binding domain containing protein
Giardia lamblia GL50803_8722   Myb 1-like protein
Homo sapiens ENSG00000118513   v-myb avian myeloblastosis viral oncogene homolog
Homo sapiens ENSG00000185697   v-myb avian myeloblastosis viral oncogene homolog-like 1
Mus musculus ENSMUSG00000019982   myeloblastosis oncogene
Mus musculus ENSMUSG00000025912   myeloblastosis oncogene-like 1
Neospora caninum NCLIV_038230   Os10g0478300 protein, related
Oryza sativa 4328551   Os02g0187700
Oryza sativa 4351856   Os12g0238000
Oryza sativa 4327192   Os01g0229000
Oryza sativa 4327399   Os01g0841500
Oryza sativa 4324828   Os01g0855400
Oryza sativa 4339005   Os05g0459000
Oryza sativa 4341607   Os06g0637500
Saccharomyces cerevisiae YKR099W   Bas1p
Toxoplasma gondii TGME49_200385   Myb family DNA-binding domain-containing protein
Trichomonas vaginalis TVAG_339390   MYB, putative
Trichomonas vaginalis TVAG_413630   C-MYB, putative
Trichomonas vaginalis TVAG_329500   r2r3-MYB transcription factor, putative
Trichomonas vaginalis TVAG_457400   r2r3-MYB transcription factor, putative
Trichomonas vaginalis TVAG_476050   r2r3-MYB transcription factor, putative
Trichomonas vaginalis TVAG_180160   MYB3r3, putative
Trichomonas vaginalis TVAG_470090   r2r3-MYB transcription factor, putative
Trichomonas vaginalis TVAG_084520   MYB72, putative
Trichomonas vaginalis TVAG_498760   pc-MYB2, putative
Trichomonas vaginalis TVAG_225360   r2r3-MYB transcription factor, putative
Trichomonas vaginalis TVAG_303430   pc-MYB2, putative
Trichomonas vaginalis TVAG_334230   r2r3-MYB transcription factor, putative
Trichomonas vaginalis TVAG_096800   r2r3-MYB transcription factor, putative
Trichomonas vaginalis TVAG_250730   C-MYB, putative
Trichomonas vaginalis TVAG_113690   r2r3-MYB transcription factor, putative

Essentiality

EHI_012420 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
TGME49_200385 Toxoplasma gondii Probably non-essential sidik
Show/Hide essentiality data references
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.


Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Gallus gallus Transcriptional activator Myb Compounds References
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets

Obtained from network model

Ranking Plot


Putative Drugs List


Compound Raw Global Species
0.0009 0.4844 0.5
0.0009 0.566 0.5

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier EHI_012420 (Entamoeba histolytica), myb-like DNA-binding domain containing protein
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