pI: 7.2337 |
Length (AA): 870 |
MW (Da): 95574 |
Paralog Number:
3
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 3 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
1 | 466 | 3k9d (A) | 3 | 456 | 42.00 | 0 | 1 | 1.05093 | -0.43 |
11 | 456 | 5j78 (A) | 34 | 467 | 47.00 | 0 | 1 | 1.10394 | -0.61 |
461 | 869 | 3zdr (A) | 459 | 869 | 58.00 | 0 | 1 | 1.21941 | -1.19 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Upper 60-80% percentile | Trophozoite. | Hon CC |
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Mid 40-60% percentile | Rahman HM-1 IMSS Trophozoite. | Hon CC |
Hon CC | Transcriptomics of virulent and avirulent strains |
Ortholog group members (OG5_127140)
Species | Accession | Gene Product |
---|---|---|
Caenorhabditis elegans | CELE_Y38F1A.6 | Protein Y38F1A.6 |
Cryptosporidium hominis | Chro.80199 | aldehyde-alcohol dehydrogenase E |
Cryptosporidium parvum | cgd8_1720 | acetaldehyde reductase plus alcohol dehydrogenase (AdhE) of possible bacterial origin |
Dictyostelium discoideum | DDB_G0290111 | alcohol dehydrogenase iron-containing 1 |
Drosophila melanogaster | Dmel_CG3425 | Type III alcohol dehydrogenase |
Escherichia coli | b1241 | fused acetaldehyde-CoA dehydrogenase/iron-dependent alcohol dehydrogenase/pyruvate-formate lyase deactivase |
Escherichia coli | b2453 | ethanol dehydrogenase involved in ethanolamine utilization |
Escherichia coli | b3589 | putative Fe-containing alcohol dehydrogenase, Pfam00465 family |
Escherichia coli | b2799 | L-1,2-propanediol oxidoreductase |
Entamoeba histolytica | EHI_150490 | aldehyde-alcohol dehydrogenase 2, putative |
Entamoeba histolytica | EHI_160940 | aldehyde-alcohol dehydrogenase 2, putative |
Entamoeba histolytica | EHI_000410 | alcohol dehydrogenase, putative |
Entamoeba histolytica | EHI_024240 | aldehyde-alcohol dehydrogenase 2, putative |
Giardia lamblia | GL50803_13350 | Alcohol dehydrogenase lateral transfer candidate |
Giardia lamblia | GL50803_3861 | Alcohol dehydrogenase 3 lateral transfer candidate |
Giardia lamblia | GL50803_93358 | Alcohol dehydrogenase |
Homo sapiens | ENSG00000147576 | alcohol dehydrogenase, iron containing, 1 |
Leishmania braziliensis | LbrM.30.2040 | alcohol dehydrogenase, putative |
Leishmania donovani | LdBPK_302100.1 | alcohol dehydrogenase, putative |
Leishmania infantum | LinJ.30.2100 | alcohol dehydrogenase, putative |
Leishmania major | LmjF.30.2090 | alcohol dehydrogenase, putative |
Leishmania mexicana | LmxM.29.2090 | alcohol dehydrogenase, putative |
Mus musculus | ENSMUSG00000025911 | alcohol dehydrogenase, iron containing, 1 |
Mycobacterium ulcerans | MUL_3976 | bifunctional acetaldehyde-CoA/alcohol dehydrogenase |
Saccharomyces cerevisiae | YGL256W | alcohol dehydrogenase ADH4 |
Schmidtea mediterranea | mk4.001225.00 | Probable hydroxyacid-oxoacid transhydrogenase, mitochondrial |
Trypanosoma cruzi | TcCLB.506357.50 | alcohol dehydrogenase, putative |
Trypanosoma cruzi | TcCLB.511277.60 | alcohol dehydrogenase, putative |
Trichomonas vaginalis | TVAG_013020 | alcohol acetaldehyde dehydrogenase, putative |
Trichomonas vaginalis | TVAG_327470 | alcohol dehydrogenase, putative |
Trichomonas vaginalis | TVAG_422780 | alcohol dehydrogenase, putative |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
b1241 | Escherichia coli | non-essential | goodall |
b2453 | Escherichia coli | non-essential | goodall |
b2799 | Escherichia coli | non-essential | goodall |
b3589 | Escherichia coli | non-essential | goodall |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.