Detailed view for EHI_008030

Basic information

TDR Targets ID: 802489
Entamoeba histolytica, phosphate transporter, putative
Source Database / ID:  AmoebaDB  

pI: 6.3385 | Length (AA): 432 | MW (Da): 47565 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 12

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF07690   Major Facilitator Superfamily

Gene Ontology

Mouse over links to read term descriptions.
GO:0016021   integral to membrane  
GO:0005215   transporter activity  
GO:0055085   transmembrane transport  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 3 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
3 417 4j05 (A) 30 509 32.00 0 1 1.30785 -0.34
7 418 4gc0 (A) 14 474 25.00 0.000012 0.88 0.979904 0.55
76 162 1bev (3) 44 135 36.00 0.82 0.03 0.205589 2.52

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

Upregulation Percent Ranking Stage Dataset
Upper 80-100% percentile Trophozoite, Rahman HM-1 IMSS Trophozoite. Hon CC
Show/Hide expression data references
  • Hon CC Transcriptomics of virulent and avirulent strains

Orthologs

Ortholog group members (OG5_127743)

Species Accession Gene Product
Arabidopsis thaliana AT5G43340   6
Arabidopsis thaliana AT5G43350   1
Arabidopsis thaliana AT2G38940   4
Arabidopsis thaliana AT2G32830   5
Arabidopsis thaliana AT5G43360   3
Arabidopsis thaliana AT5G43370   2
Arabidopsis thaliana AT3G54700   7
Candida albicans CaO19.8765   inorganic phosphate permease
Candida albicans CaO19.1172   inorganic phosphate permease
Candida albicans CaO19.655   inorganic phosphate transporter, transmembrane protein
Candida albicans CaO19.8269   inorganic phosphate transporter, transmembrane protein
Dictyostelium discoideum DDB_G0282311   MFS family protein
Entamoeba histolytica EHI_008030   phosphate transporter, putative
Oryza sativa 4331634   Os03g0150500
Oryza sativa 4348740   Os10g0444600
Oryza sativa 4331635   Os03g0150600
Oryza sativa 4335113   Os04g0185600
Oryza sativa 4348741   Os10g0444700
Oryza sativa 4331542   Os03g0136400
Oryza sativa 4324187   Os01g0657100
Oryza sativa 4331637   Os03g0150800
Oryza sativa 4346342   Os08g0564000
Oryza sativa 4335115   Os04g0186400
Saccharomyces cerevisiae YML123C   Pho84p

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier EHI_008030 (Entamoeba histolytica), phosphate transporter, putative
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