pI: 4.878 |
Length (AA): 315 |
MW (Da): 35526 |
Paralog Number:
0
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 3 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
1 | 315 | 2h6f (B) | 571 | 900 | 31.00 | 0 | 1 | 1.4513 | -1.18 |
1 | 311 | 1n4q (B) | 18 | 353 | 30.00 | 0 | 1 | 1.3896 | -1.32 |
2 | 314 | 1ltx (B) | 17 | 325 | 49.00 | 0 | 1 | 1.70995 | -1.72 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Upper 60-80% percentile | Trophozoite. | Hon CC |
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Mid 40-60% percentile | Rahman HM-1 IMSS Trophozoite. | Hon CC |
Hon CC | Transcriptomics of virulent and avirulent strains |
Ortholog group members (OG5_127744)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT5G12210 | RAB geranylgeranyl transferase beta subunit 1 |
Arabidopsis thaliana | AT3G12070 | RAB geranylgeranyl transferase beta subunit 2 |
Babesia bovis | BBOV_I004600 | geranylgeranyl transferase type II beta subunit, putative |
Brugia malayi | Bm1_33245 | Probable protein farnesyltransferase beta subunit, putative |
Candida albicans | CaO19.7563 | similar to S. cerevisiae BET2 (YPR176C) RAB-protein geranylgeranyltransferase type II beta subunit |
Caenorhabditis elegans | CELE_B0280.1 | Protein GGTB-1, isoform B |
Cryptosporidium hominis | Chro.60212 | prenyltransferase subunit |
Cryptosporidium parvum | cgd6_1750 | Rab geranylgeranyl transferase beta / prenyltransferase; alpha/alpha toroid fold |
Dictyostelium discoideum | DDB_G0290671 | Rab geranylgeranyltransferase beta subunit |
Drosophila melanogaster | Dmel_CG18627 | beta subunit of type II geranylgeranyl transferase |
Entamoeba histolytica | EHI_025110 | Rab geranylgeranyltransferase beta subunit, putative |
Echinococcus multilocularis | EmuJ_000573700 | Rab geranylgeranyltransferase, beta subunit |
Giardia lamblia | GL50803_17082 | Rab geranylgeranyltransferase |
Homo sapiens | ENSG00000137955 | Rab geranylgeranyltransferase, beta subunit |
Leishmania braziliensis | LbrM.20.3660 | geranylgeranyltransferase, putative |
Leishmania donovani | LdBPK_343860.1 | geranylgeranyltransferase, putative |
Leishmania infantum | LinJ.34.3860 | geranylgeranyltransferase, putative |
Leishmania major | LmjF.34.4030 | geranylgeranyltransferase, putative |
Leishmania mexicana | LmxM.33.4030 | geranylgeranyltransferase, putative |
Loa Loa (eye worm) | LOAG_05820 | hypothetical protein |
Loa Loa (eye worm) | LOAG_01843 | hypothetical protein |
Mus musculus | ENSMUSG00000038975 | Rab geranylgeranyl transferase, b subunit |
Neospora caninum | NCLIV_058780 | hypothetical protein |
Oryza sativa | 9266476 | Os03g0193700 |
Oryza sativa | 4346013 | Os08g0512300 |
Plasmodium berghei | PBANKA_0101300 | geranylgeranyltransferase, putative |
Plasmodium falciparum | PF3D7_0602500 | geranylgeranyltransferase, putative |
Plasmodium knowlesi | PKNH_1148200 | geranylgeranyltransferase, putative |
Plasmodium vivax | PVX_113290 | geranylgeranyltransferase, putative |
Plasmodium yoelii | PY07078 | hypothetical protein |
Saccharomyces cerevisiae | YPR176C | Bet2p |
Schistosoma japonicum | Sjp_0090410 | ko:K05956 similar to Rab geranylgeranyltransferase, beta subunit [EC:2.5.1.60], putative |
Schistosoma mansoni | Smp_150160 | geranylgeranyl transferase type II beta subunit |
Schmidtea mediterranea | mk4.036045.01 | Probable geranylgeranyl transferase type-2 subunit beta |
Schmidtea mediterranea | mk4.001084.12 | Probable geranylgeranyl transferase type-2 subunit beta |
Trypanosoma brucei gambiense | Tbg972.4.460 | geranylgeranyl transferase type II beta subunit, putative |
Trypanosoma brucei | Tb927.4.690 | geranylgeranyl transferase type II beta subunit, putative |
Trypanosoma congolense | TcIL3000_0_29030 | geranylgeranyl transferase type II beta subunit, putative |
Trypanosoma congolense | TcIL3000_4_310 | geranylgeranyl transferase type II beta subunit, putative |
Trypanosoma cruzi | TcCLB.507053.70 | geranylgeranyl transferase type II beta subunit, putative |
Toxoplasma gondii | TGME49_316270 | Rab geranylgeranyl transferase type II beta subunit, putative |
Theileria parva | TP03_0500 | geranylgeranyl transferase type 2 beta subunit, putative |
Trichomonas vaginalis | TVAG_442870 | protein farnesyltransferase beta subunit, putative |
Trichomonas vaginalis | TVAG_214620 | protein farnesyltransferase beta subunit, putative |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
Tb927.4.690 | Trypanosoma brucei | no significant loss or gain of fitness in bloodstream forms (3 days) | alsford |
Tb927.4.690 | Trypanosoma brucei | significant loss of fitness in bloodstream forms (6 days) | alsford |
Tb927.4.690 | Trypanosoma brucei | no significant loss or gain of fitness in procyclic forms | alsford |
Tb927.4.690 | Trypanosoma brucei | no significant loss or gain of fitness in differentiation of procyclic to bloodstream forms | alsford |
CELE_B0280.1 | Caenorhabditis elegans | embryonic lethal | wormbase |
CELE_B0280.1 | Caenorhabditis elegans | sterile | wormbase |
YPR176C | Saccharomyces cerevisiae | inviable | yeastgenome |
PBANKA_0101300 | Plasmodium berghei | Essential | plasmo |
TGME49_316270 | Toxoplasma gondii | Probably essential | sidik |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.